Community control strategies for scabies: A cluster randomised noninferiority trial

Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advan...

Full description

Saved in:
Bibliographic Details
Published inPLoS medicine Vol. 18; no. 11; p. e1003849
Main Authors Hardy, Myra, Samuela, Josaia, Kama, Mike, Tuicakau, Meciusela, Romani, Lucia, Whitfeld, Margot J, King, Christopher L, Weil, Gary J, Schuster, Tibor, Grobler, Anneke C, Engelman, Daniel, Robinson, Leanne J, Kaldor, John M, Steer, Andrew C
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 10.11.2021
Public Library of Science (PLoS)
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advantages for implementing MDA for scabies at large scale. We did a cluster randomised, noninferiority, open-label, 3-group unblinded study comparing the effectiveness of control strategies on community prevalence of scabies at 12 months. All residents from 35 villages on 2 Fijian islands were eligible to participate. Villages were randomised 1:1:1 to 2-dose ivermectin-based MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen and treat with topical permethrin 5% for individuals with scabies and their household contacts (SAT). All groups also received diethylcarbamazine and albendazole for lymphatic filariasis control. For IVM-2 and IVM-1, oral ivermectin was dosed at 200 μg/kg and when contraindicated substituted with permethrin. We designated a noninferiority margin of 5%. We enrolled 3,812 participants at baseline (July to November 2017) from the 35 villages with median village size of 108 (range 18 to 298). Age and sex of participants were representative of the population with 51.6% male and median age of 25 years (interquartile range 10 to 47). We enrolled 3,898 at 12 months (July to November 2018). At baseline, scabies prevalence was similar in all groups: IVM-2: 11.7% (95% confidence interval (CI) 8.5 to 16.0); IVM-1: 15.2% (95% CI 9.4 to 23.8); SAT: 13.6% (95% CI 7.9 to 22.4). At 12 months, scabies decreased substantially in all groups: IVM-2: 1.3% (95% CI 0.6 to 2.5); IVM-1: 2.7% (95% CI 1.1 to 6.5); SAT: 1.1% (95% CI 0.6 to 2.0). The risk difference in scabies prevalence at 12 months between the IVM-1 and IVM-2 groups was 1.2% (95% CI -0.2 to 2.7, p = 0.10). Limitations of the study included the method of scabies diagnosis by nonexperts, a lower baseline prevalence than anticipated, and the addition of diethylcarbamazine and albendazole to scabies treatment. All 3 strategies substantially reduced prevalence. One-dose was noninferior to 2-dose ivermectin-based MDA, as was a screen and treat approach, for community control of scabies. Further trials comparing these approaches in varied settings are warranted to inform global scabies control strategies. Clinitrials.gov NCT03177993 and ANZCTR N12617000738325.
AbstractList Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advantages for implementing MDA for scabies at large scale. We did a cluster randomised, noninferiority, open-label, 3-group unblinded study comparing the effectiveness of control strategies on community prevalence of scabies at 12 months. All residents from 35 villages on 2 Fijian islands were eligible to participate. Villages were randomised 1:1:1 to 2-dose ivermectin-based MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen and treat with topical permethrin 5% for individuals with scabies and their household contacts (SAT). All groups also received diethylcarbamazine and albendazole for lymphatic filariasis control. For IVM-2 and IVM-1, oral ivermectin was dosed at 200 [mu]g/kg and when contraindicated substituted with permethrin. We designated a noninferiority margin of 5%. All 3 strategies substantially reduced prevalence. One-dose was noninferior to 2-dose ivermectin-based MDA, as was a screen and treat approach, for community control of scabies. Further trials comparing these approaches in varied settings are warranted to inform global scabies control strategies.
Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advantages for implementing MDA for scabies at large scale. We did a cluster randomised, noninferiority, open-label, 3-group unblinded study comparing the effectiveness of control strategies on community prevalence of scabies at 12 months. All residents from 35 villages on 2 Fijian islands were eligible to participate. Villages were randomised 1:1:1 to 2-dose ivermectin-based MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen and treat with topical permethrin 5% for individuals with scabies and their household contacts (SAT). All groups also received diethylcarbamazine and albendazole for lymphatic filariasis control. For IVM-2 and IVM-1, oral ivermectin was dosed at 200 μg/kg and when contraindicated substituted with permethrin. We designated a noninferiority margin of 5%. We enrolled 3,812 participants at baseline (July to November 2017) from the 35 villages with median village size of 108 (range 18 to 298). Age and sex of participants were representative of the population with 51.6% male and median age of 25 years (interquartile range 10 to 47). We enrolled 3,898 at 12 months (July to November 2018). At baseline, scabies prevalence was similar in all groups: IVM-2: 11.7% (95% confidence interval (CI) 8.5 to 16.0); IVM-1: 15.2% (95% CI 9.4 to 23.8); SAT: 13.6% (95% CI 7.9 to 22.4). At 12 months, scabies decreased substantially in all groups: IVM-2: 1.3% (95% CI 0.6 to 2.5); IVM-1: 2.7% (95% CI 1.1 to 6.5); SAT: 1.1% (95% CI 0.6 to 2.0). The risk difference in scabies prevalence at 12 months between the IVM-1 and IVM-2 groups was 1.2% (95% CI -0.2 to 2.7, p = 0.10). Limitations of the study included the method of scabies diagnosis by nonexperts, a lower baseline prevalence than anticipated, and the addition of diethylcarbamazine and albendazole to scabies treatment. All 3 strategies substantially reduced prevalence. One-dose was noninferior to 2-dose ivermectin-based MDA, as was a screen and treat approach, for community control of scabies. Further trials comparing these approaches in varied settings are warranted to inform global scabies control strategies. Clinitrials.gov NCT03177993 and ANZCTR N12617000738325.
In a cluster randomized trial, Myra Hardy and colleagues, compare mass drug administration of one-dose and two-dose ivermectin-based treatment for community control of scabies.
Background Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advantages for implementing MDA for scabies at large scale. Methods and findings We did a cluster randomised, noninferiority, open-label, 3-group unblinded study comparing the effectiveness of control strategies on community prevalence of scabies at 12 months. All residents from 35 villages on 2 Fijian islands were eligible to participate. Villages were randomised 1:1:1 to 2-dose ivermectin-based MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen and treat with topical permethrin 5% for individuals with scabies and their household contacts (SAT). All groups also received diethylcarbamazine and albendazole for lymphatic filariasis control. For IVM-2 and IVM-1, oral ivermectin was dosed at 200 [mu]g/kg and when contraindicated substituted with permethrin. We designated a noninferiority margin of 5%. We enrolled 3,812 participants at baseline (July to November 2017) from the 35 villages with median village size of 108 (range 18 to 298). Age and sex of participants were representative of the population with 51.6% male and median age of 25 years (interquartile range 10 to 47). We enrolled 3,898 at 12 months (July to November 2018). At baseline, scabies prevalence was similar in all groups: IVM-2: 11.7% (95% confidence interval (CI) 8.5 to 16.0); IVM-1: 15.2% (95% CI 9.4 to 23.8); SAT: 13.6% (95% CI 7.9 to 22.4). At 12 months, scabies decreased substantially in all groups: IVM-2: 1.3% (95% CI 0.6 to 2.5); IVM-1: 2.7% (95% CI 1.1 to 6.5); SAT: 1.1% (95% CI 0.6 to 2.0). The risk difference in scabies prevalence at 12 months between the IVM-1 and IVM-2 groups was 1.2% (95% CI -0.2 to 2.7, p = 0.10). Limitations of the study included the method of scabies diagnosis by nonexperts, a lower baseline prevalence than anticipated, and the addition of diethylcarbamazine and albendazole to scabies treatment. Conclusions All 3 strategies substantially reduced prevalence. One-dose was noninferior to 2-dose ivermectin-based MDA, as was a screen and treat approach, for community control of scabies. Further trials comparing these approaches in varied settings are warranted to inform global scabies control strategies. Trial registration Clinitrials.gov NCT03177993 and ANZCTR N12617000738325.
BACKGROUNDScabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advantages for implementing MDA for scabies at large scale. METHODS AND FINDINGSWe did a cluster randomised, noninferiority, open-label, 3-group unblinded study comparing the effectiveness of control strategies on community prevalence of scabies at 12 months. All residents from 35 villages on 2 Fijian islands were eligible to participate. Villages were randomised 1:1:1 to 2-dose ivermectin-based MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen and treat with topical permethrin 5% for individuals with scabies and their household contacts (SAT). All groups also received diethylcarbamazine and albendazole for lymphatic filariasis control. For IVM-2 and IVM-1, oral ivermectin was dosed at 200 μg/kg and when contraindicated substituted with permethrin. We designated a noninferiority margin of 5%. We enrolled 3,812 participants at baseline (July to November 2017) from the 35 villages with median village size of 108 (range 18 to 298). Age and sex of participants were representative of the population with 51.6% male and median age of 25 years (interquartile range 10 to 47). We enrolled 3,898 at 12 months (July to November 2018). At baseline, scabies prevalence was similar in all groups: IVM-2: 11.7% (95% confidence interval (CI) 8.5 to 16.0); IVM-1: 15.2% (95% CI 9.4 to 23.8); SAT: 13.6% (95% CI 7.9 to 22.4). At 12 months, scabies decreased substantially in all groups: IVM-2: 1.3% (95% CI 0.6 to 2.5); IVM-1: 2.7% (95% CI 1.1 to 6.5); SAT: 1.1% (95% CI 0.6 to 2.0). The risk difference in scabies prevalence at 12 months between the IVM-1 and IVM-2 groups was 1.2% (95% CI -0.2 to 2.7, p = 0.10). Limitations of the study included the method of scabies diagnosis by nonexperts, a lower baseline prevalence than anticipated, and the addition of diethylcarbamazine and albendazole to scabies treatment. CONCLUSIONSAll 3 strategies substantially reduced prevalence. One-dose was noninferior to 2-dose ivermectin-based MDA, as was a screen and treat approach, for community control of scabies. Further trials comparing these approaches in varied settings are warranted to inform global scabies control strategies. TRIAL REGISTRATIONClinitrials.gov NCT03177993 and ANZCTR N12617000738325.
Background Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advantages for implementing MDA for scabies at large scale. Methods and findings We did a cluster randomised, noninferiority, open-label, 3-group unblinded study comparing the effectiveness of control strategies on community prevalence of scabies at 12 months. All residents from 35 villages on 2 Fijian islands were eligible to participate. Villages were randomised 1:1:1 to 2-dose ivermectin-based MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen and treat with topical permethrin 5% for individuals with scabies and their household contacts (SAT). All groups also received diethylcarbamazine and albendazole for lymphatic filariasis control. For IVM-2 and IVM-1, oral ivermectin was dosed at 200 μg/kg and when contraindicated substituted with permethrin. We designated a noninferiority margin of 5%. We enrolled 3,812 participants at baseline (July to November 2017) from the 35 villages with median village size of 108 (range 18 to 298). Age and sex of participants were representative of the population with 51.6% male and median age of 25 years (interquartile range 10 to 47). We enrolled 3,898 at 12 months (July to November 2018). At baseline, scabies prevalence was similar in all groups: IVM-2: 11.7% (95% confidence interval (CI) 8.5 to 16.0); IVM-1: 15.2% (95% CI 9.4 to 23.8); SAT: 13.6% (95% CI 7.9 to 22.4). At 12 months, scabies decreased substantially in all groups: IVM-2: 1.3% (95% CI 0.6 to 2.5); IVM-1: 2.7% (95% CI 1.1 to 6.5); SAT: 1.1% (95% CI 0.6 to 2.0). The risk difference in scabies prevalence at 12 months between the IVM-1 and IVM-2 groups was 1.2% (95% CI −0.2 to 2.7, p = 0.10). Limitations of the study included the method of scabies diagnosis by nonexperts, a lower baseline prevalence than anticipated, and the addition of diethylcarbamazine and albendazole to scabies treatment. Conclusions All 3 strategies substantially reduced prevalence. One-dose was noninferior to 2-dose ivermectin-based MDA, as was a screen and treat approach, for community control of scabies. Further trials comparing these approaches in varied settings are warranted to inform global scabies control strategies. Trial registration Clinitrials.gov NCT03177993 and ANZCTR N12617000738325.
Background Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug administration (MDA) using 2 doses of ivermectin-based treatment. If effective, a strategy of 1-dose ivermectin-based MDA would have substantial advantages for implementing MDA for scabies at large scale. Methods and findings We did a cluster randomised, noninferiority, open-label, 3-group unblinded study comparing the effectiveness of control strategies on community prevalence of scabies at 12 months. All residents from 35 villages on 2 Fijian islands were eligible to participate. Villages were randomised 1:1:1 to 2-dose ivermectin-based MDA (IVM-2), 1-dose ivermectin-based MDA (IVM-1), or screen and treat with topical permethrin 5% for individuals with scabies and their household contacts (SAT). All groups also received diethylcarbamazine and albendazole for lymphatic filariasis control. For IVM-2 and IVM-1, oral ivermectin was dosed at 200 μg/kg and when contraindicated substituted with permethrin. We designated a noninferiority margin of 5%. We enrolled 3,812 participants at baseline (July to November 2017) from the 35 villages with median village size of 108 (range 18 to 298). Age and sex of participants were representative of the population with 51.6% male and median age of 25 years (interquartile range 10 to 47). We enrolled 3,898 at 12 months (July to November 2018). At baseline, scabies prevalence was similar in all groups: IVM-2: 11.7% (95% confidence interval (CI) 8.5 to 16.0); IVM-1: 15.2% (95% CI 9.4 to 23.8); SAT: 13.6% (95% CI 7.9 to 22.4). At 12 months, scabies decreased substantially in all groups: IVM-2: 1.3% (95% CI 0.6 to 2.5); IVM-1: 2.7% (95% CI 1.1 to 6.5); SAT: 1.1% (95% CI 0.6 to 2.0). The risk difference in scabies prevalence at 12 months between the IVM-1 and IVM-2 groups was 1.2% (95% CI −0.2 to 2.7, p = 0.10). Limitations of the study included the method of scabies diagnosis by nonexperts, a lower baseline prevalence than anticipated, and the addition of diethylcarbamazine and albendazole to scabies treatment. Conclusions All 3 strategies substantially reduced prevalence. One-dose was noninferior to 2-dose ivermectin-based MDA, as was a screen and treat approach, for community control of scabies. Further trials comparing these approaches in varied settings are warranted to inform global scabies control strategies. Trial registration Clinitrials.gov NCT03177993 and ANZCTR N12617000738325.
Audience Academic
Author Whitfeld, Margot J
Tuicakau, Meciusela
Schuster, Tibor
Engelman, Daniel
Robinson, Leanne J
Steer, Andrew C
King, Christopher L
Weil, Gary J
Hardy, Myra
Romani, Lucia
Kaldor, John M
Samuela, Josaia
Grobler, Anneke C
Kama, Mike
AuthorAffiliation 6 Center for Global Health and Diseases, Case Western Reserve University and Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
7 Department of Medicine, Washington University, St. Louis, Missouri, United States of America
4 Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia
1 Tropical Diseases, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
2 Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
Mahidol-Oxford Tropical Medicine Research Unit, THAILAND
9 Clinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
10 Vector-borne Diseases and Tropical Public Health, Burnet Institute, Melbourne, Victoria, Australia
8 Department of Family Medicine, McGill University, Montreal, Quebec, Canada
3 Fiji Ministry of Health and Medical Services, Suva, Fiji
5 St Vincent’s Hospital, University of New South Wales, Sydney, New South Wales, Australi
AuthorAffiliation_xml – name: 3 Fiji Ministry of Health and Medical Services, Suva, Fiji
– name: 1 Tropical Diseases, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
– name: 7 Department of Medicine, Washington University, St. Louis, Missouri, United States of America
– name: Mahidol-Oxford Tropical Medicine Research Unit, THAILAND
– name: 8 Department of Family Medicine, McGill University, Montreal, Quebec, Canada
– name: 4 Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia
– name: 9 Clinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
– name: 2 Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
– name: 5 St Vincent’s Hospital, University of New South Wales, Sydney, New South Wales, Australia
– name: 6 Center for Global Health and Diseases, Case Western Reserve University and Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
– name: 10 Vector-borne Diseases and Tropical Public Health, Burnet Institute, Melbourne, Victoria, Australia
Author_xml – sequence: 1
  givenname: Myra
  orcidid: 0000-0003-3482-6348
  surname: Hardy
  fullname: Hardy, Myra
  organization: Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
– sequence: 2
  givenname: Josaia
  orcidid: 0000-0002-1288-5948
  surname: Samuela
  fullname: Samuela, Josaia
  organization: Fiji Ministry of Health and Medical Services, Suva, Fiji
– sequence: 3
  givenname: Mike
  surname: Kama
  fullname: Kama, Mike
  organization: Fiji Ministry of Health and Medical Services, Suva, Fiji
– sequence: 4
  givenname: Meciusela
  surname: Tuicakau
  fullname: Tuicakau, Meciusela
  organization: Fiji Ministry of Health and Medical Services, Suva, Fiji
– sequence: 5
  givenname: Lucia
  orcidid: 0000-0001-9038-5300
  surname: Romani
  fullname: Romani, Lucia
  organization: Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia
– sequence: 6
  givenname: Margot J
  surname: Whitfeld
  fullname: Whitfeld, Margot J
  organization: St Vincent's Hospital, University of New South Wales, Sydney, New South Wales, Australia
– sequence: 7
  givenname: Christopher L
  orcidid: 0000-0003-3873-7860
  surname: King
  fullname: King, Christopher L
  organization: Center for Global Health and Diseases, Case Western Reserve University and Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
– sequence: 8
  givenname: Gary J
  orcidid: 0000-0002-6336-3824
  surname: Weil
  fullname: Weil, Gary J
  organization: Department of Medicine, Washington University, St. Louis, Missouri, United States of America
– sequence: 9
  givenname: Tibor
  orcidid: 0000-0002-3620-3526
  surname: Schuster
  fullname: Schuster, Tibor
  organization: Department of Family Medicine, McGill University, Montreal, Quebec, Canada
– sequence: 10
  givenname: Anneke C
  surname: Grobler
  fullname: Grobler, Anneke C
  organization: Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Victoria, Australia
– sequence: 11
  givenname: Daniel
  orcidid: 0000-0002-4909-1287
  surname: Engelman
  fullname: Engelman, Daniel
  organization: Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
– sequence: 12
  givenname: Leanne J
  orcidid: 0000-0001-9903-1023
  surname: Robinson
  fullname: Robinson, Leanne J
  organization: Vector-borne Diseases and Tropical Public Health, Burnet Institute, Melbourne, Victoria, Australia
– sequence: 13
  givenname: John M
  orcidid: 0000-0002-7639-4355
  surname: Kaldor
  fullname: Kaldor, John M
  organization: Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia
– sequence: 14
  givenname: Andrew C
  orcidid: 0000-0001-7346-0196
  surname: Steer
  fullname: Steer, Andrew C
  organization: Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34758017$$D View this record in MEDLINE/PubMed
BookMark eNqVk12L1DAUhousuLuj_0C0IIhezJikaT68EIbBj4HFBVe9DWmbdDKkzZik4v57M053mcpcKL1oSJ7z5pz35FxmZ73rVZY9hWABCwrfbN3ge2kXu041CwhAwTB_kF3AEvM5JJScHa3Ps8sQtgAgDjh4lJ0XmJYMQHqR3axc1w29ibd57fronc1D9DKq1qiQa-fzUMsqrd_my7y2Q4jK5172jetMUE2ekjK9Vt44v9eI3kj7OHuopQ3qyfifZd8-vP-6-jS_uv64Xi2v5jUlOM5JA2tEOaaQlKVEAFYYFlxKwgAt60ZTTBWqKoQwIxgiWYEyhahKSY0007yYZc8Pujvrghj9CAIRCDhGiOFErA9E4-RW7LzppL8VThrxZ8P5VkgfTW2VqBDWqmEUA4gxkYpRDqDkFcO40gXRSevdeNtQJctrldySdiI6PenNRrTup2AEojKVNstejQLe_RhUiCJZWCtrZa_ckPIuOcElIwAl9MVf6OnqRqqVqYDUBpfurfeiYkkYLpNrnCVqfoJqVa9SkulJaZO2J_ziBJ--RnWmPhnwehKwf0fqV2zlEIJY33z5D_bzv7PX36fsyyN2o6SNm-DsEI3rwxTEB7D2LgSv9H0DIRD7ubpzWuznSoxzlcKeHTf_PuhukIrfw1wdtQ
CitedBy_id crossref_primary_10_3390_tropicalmed8040200
crossref_primary_10_1371_journal_pntd_0011207
crossref_primary_10_1371_journal_pntd_0011549
crossref_primary_10_1016_j_lanwpc_2023_100942
crossref_primary_10_1016_S2214_109X_23_00134_1
crossref_primary_10_1186_s40249_024_01185_5
crossref_primary_10_1098_rstb_2022_0433
Cites_doi 10.1136/bmjopen-2020-037305
10.2471/BLT.08.052712
10.1371/journal.pntd.0009330
10.1056/NEJMc1808439
10.1056/NEJMct0910329
10.1111/bjd.18517
10.1016/S0140-6736(19)31136-5
10.1371/journal.pntd.0000467
10.1186/s13071-021-04645-1
10.1186/1756-3305-5-299
10.1371/journal.pntd.0008106
10.1371/journal.pntd.0003452
10.1056/NEJMoa1500987
10.1016/j.cct.2012.05.004
10.1093/cid/ciz444
10.1016/S1473-3099(18)30790-4
10.1093/cid/ciy574
10.1371/journal.pntd.0007635
ContentType Journal Article
Copyright COPYRIGHT 2021 Public Library of Science
2021 Hardy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 Hardy et al 2021 Hardy et al
Copyright_xml – notice: COPYRIGHT 2021 Public Library of Science
– notice: 2021 Hardy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2021 Hardy et al 2021 Hardy et al
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
IOV
ISN
ISR
3V.
7TK
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
CZK
DOI 10.1371/journal.pmed.1003849
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Gale In Context: Opposing Viewpoints
Gale In Context: Canada
Gale In Context: Science
ProQuest Central (Corporate)
Neurosciences Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
PLoS Medicine
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Neurosciences Abstracts
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE





MEDLINE - Academic




Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 7X7
  name: ProQuest Health and Medical
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Geography
DocumentTitleAlternate Mass drug administration for scabies
EISSN 1549-1676
Editor von Seidlein, Lorenz
Editor_xml – sequence: 1
  givenname: Lorenz
  surname: von Seidlein
  fullname: von Seidlein, Lorenz
EndPage e1003849
ExternalDocumentID 2610942284
oai_doaj_org_article_b24fed87401446ae87901a9b844bf36f
A684564198
10_1371_journal_pmed_1003849
34758017
Genre Equivalence Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Fiji
Rotuma
GeographicLocations_xml – name: Fiji
– name: Rotuma
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: OPPGH5342
– fundername: ;
  grantid: OPP1190754
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7X7
88E
8FI
8FJ
AAFWJ
AAWTL
ABDBF
ABUWG
ACGFO
ACIHN
ACPRK
ADBBV
ADRAZ
AEAQA
AENEX
AFKRA
AFRAH
AFXKF
AHMBA
AKRSQ
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
B0M
BAWUL
BCGST
BCNDV
BENPR
BPHCQ
BVXVI
BWKFM
CCPQU
CGR
CS3
CUY
CVF
DIK
DU5
E3Z
EAP
EAS
EBD
EBS
ECM
EIF
EJD
EMK
EMOBN
ESX
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
H13
HMCUK
HYE
IAO
ICW
IHR
IHW
INH
INR
IOF
IOV
IPNFZ
IPO
ISN
ISR
ITC
KQ8
M1P
M48
MK0
M~E
NPM
O5R
O5S
OK1
P2P
PIMPY
PQQKQ
PROAC
PSQYO
PV9
RIG
RNS
RPM
RZL
SV3
TR2
TUS
UKHRP
WOQ
WOW
XSB
YZZ
~8M
AAYXX
CITATION
AFPKN
7TK
7XB
8FK
AZQEC
DWQXO
K9.
PQEST
PQUKI
PRINS
7X8
5PM
AAPBV
ABPTK
ACDSR
BBAFP
CZK
UMP
ID FETCH-LOGICAL-c764t-6d1c279471655a201b4139aa68075cdf747e2bb22486412ab056d1ebeaf2f8f93
IEDL.DBID RPM
ISSN 1549-1676
1549-1277
IngestDate Mon Dec 05 23:08:20 EST 2022
Tue Oct 22 15:13:56 EDT 2024
Tue Sep 17 20:56:47 EDT 2024
Sat Oct 26 00:47:29 EDT 2024
Thu Oct 10 17:17:48 EDT 2024
Tue Nov 19 20:53:08 EST 2024
Thu Nov 14 20:41:57 EST 2024
Tue Nov 12 22:43:15 EST 2024
Thu Aug 01 19:40:02 EDT 2024
Thu Aug 01 19:55:07 EDT 2024
Thu Aug 01 19:58:31 EDT 2024
Tue Aug 20 22:13:03 EDT 2024
Fri Nov 22 07:08:11 EST 2024
Wed Oct 16 00:43:51 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 11
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c764t-6d1c279471655a201b4139aa68075cdf747e2bb22486412ab056d1ebeaf2f8f93
Notes new_version
SourceType-Scholarly Journals-1
ObjectType-Feature-4
ObjectType-Undefined-1
ObjectType-News-2
content type line 23
ObjectType-Article-3
I have read the journal’s policy and the authors of this manuscript have the following competing interests: M. H. and G. J. W. report grants from the Bill & Melinda Gates Foundation. M. H. reports a grant from Australian Centre for the Control and Elimination of Neglected Tropical Diseases, National Health Medical Research Council Centre for Research Excellence, during the conduct of the study. All other authors have declared that no competing interests exist.
ORCID 0000-0003-3482-6348
0000-0002-3620-3526
0000-0002-4909-1287
0000-0003-3873-7860
0000-0002-7639-4355
0000-0001-9903-1023
0000-0002-1288-5948
0000-0002-6336-3824
0000-0001-9038-5300
0000-0001-7346-0196
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612541/
PMID 34758017
PQID 2610942284
PQPubID 1436338
ParticipantIDs plos_journals_2610942284
doaj_primary_oai_doaj_org_article_b24fed87401446ae87901a9b844bf36f
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8612541
proquest_miscellaneous_2596458602
proquest_journals_2610942284
gale_infotracmisc_A684564198
gale_infotracgeneralonefile_A684564198
gale_infotracacademiconefile_A684564198
gale_incontextgauss_ISR_A684564198
gale_incontextgauss_ISN_A684564198
gale_incontextgauss_IOV_A684564198
gale_healthsolutions_A684564198
crossref_primary_10_1371_journal_pmed_1003849
pubmed_primary_34758017
PublicationCentury 2000
PublicationDate 20211110
PublicationDateYYYYMMDD 2021-11-10
PublicationDate_xml – month: 11
  year: 2021
  text: 20211110
  day: 10
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PLoS medicine
PublicationTitleAlternate PLoS Med
PublicationYear 2021
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References L Romani (pmed.1003849.ref004) 2015; 9
KA Mohammed (pmed.1003849.ref012) 2012; 5
A Matthews (pmed.1003849.ref023) 2021; 14
L Romani (pmed.1003849.ref006) 2019; 381
C Bernigaud (pmed.1003849.ref009) 2020; 182
M Marks (pmed.1003849.ref008) 2020; 70
AC Steer (pmed.1003849.ref016) 2009; 87
D Engelman (pmed.1003849.ref001) 2019; 394
AC Steer (pmed.1003849.ref003) 2009; 3
pmed.1003849.ref015
pmed.1003849.ref002
P Behera (pmed.1003849.ref020) 2021; 15
pmed.1003849.ref011
BJ Currie (pmed.1003849.ref010) 2010; 362
M Hardy (pmed.1003849.ref014) 2021
S Wu (pmed.1003849.ref018) 2012; 33
MH Osti (pmed.1003849.ref021) 2019; 13
M Marks (pmed.1003849.ref019) 2019; 68
L Romani (pmed.1003849.ref005) 2015; 373
L Romani (pmed.1003849.ref007) 2019; 19
SJ Lake (pmed.1003849.ref022) 2020; 10
M Hardy (pmed.1003849.ref013) 2020; 14
pmed.1003849.ref017
References_xml – volume: 10
  start-page: e037305
  issue: 8
  year: 2020
  ident: pmed.1003849.ref022
  article-title: Protocol for a cluster-randomised non-inferiority trial of one versus two doses of ivermectin for the control of scabies using a mass drug administration strategy (the RISE study)
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2020-037305
  contributor:
    fullname: SJ Lake
– year: 2021
  ident: pmed.1003849.ref014
  article-title: Individual efficacy and community impact of ivermectin, diethylcarbamazine and albendazole mass drug administration for lymphatic filariasis control in Fiji: a cluster randomised trial
  publication-title: Clin Infect Dis
  contributor:
    fullname: M Hardy
– volume: 87
  start-page: 173
  issue: 3
  year: 2009
  ident: pmed.1003849.ref016
  article-title: Validation of an Integrated Management of Childhood Illness algorithm for managing common skin conditions in Fiji
  publication-title: Bull World Health Organ
  doi: 10.2471/BLT.08.052712
  contributor:
    fullname: AC Steer
– volume: 15
  start-page: e0009330
  issue: 4
  year: 2021
  ident: pmed.1003849.ref020
  article-title: Control of scabies in a tribal community using mass screening and treatment with oral ivermectin -A cluster randomized controlled trial in Gadchiroli, India
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0009330
  contributor:
    fullname: P Behera
– volume: 381
  start-page: 186
  issue: 2
  year: 2019
  ident: pmed.1003849.ref006
  article-title: Mass Drug Administration for Scabies—2 Years of Follow-up
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc1808439
  contributor:
    fullname: L Romani
– volume: 362
  start-page: 717
  issue: 8
  year: 2010
  ident: pmed.1003849.ref010
  article-title: Permethrin and ivermectin for scabies
  publication-title: N Engl J Med
  doi: 10.1056/NEJMct0910329
  contributor:
    fullname: BJ Currie
– volume: 182
  start-page: 511
  issue: 2
  year: 2020
  ident: pmed.1003849.ref009
  article-title: In vitro ovicidal activity of current and under-development scabicides: which treatments kill scabies eggs?
  publication-title: Br J Dermatol
  doi: 10.1111/bjd.18517
  contributor:
    fullname: C Bernigaud
– volume: 394
  start-page: 81
  issue: 10192
  year: 2019
  ident: pmed.1003849.ref001
  article-title: The public health control of scabies: priorities for research and action
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)31136-5
  contributor:
    fullname: D Engelman
– volume: 3
  start-page: e467
  issue: 6
  year: 2009
  ident: pmed.1003849.ref003
  article-title: High burden of impetigo and scabies in a tropical country
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0000467
  contributor:
    fullname: AC Steer
– volume: 14
  start-page: 156
  issue: 1
  year: 2021
  ident: pmed.1003849.ref023
  article-title: Prevalence of scabies and impetigo in school-age children in Timor-Leste
  publication-title: Parasit Vectors
  doi: 10.1186/s13071-021-04645-1
  contributor:
    fullname: A Matthews
– volume: 5
  start-page: 299
  year: 2012
  ident: pmed.1003849.ref012
  article-title: Soil transmitted helminths and scabies in Zanzibar, Tanzania following mass drug administration for lymphatic filariasis—a rapid assessment methodology to assess impact
  publication-title: Parasit Vectors
  doi: 10.1186/1756-3305-5-299
  contributor:
    fullname: KA Mohammed
– volume: 14
  start-page: e0008106
  issue: 3
  year: 2020
  ident: pmed.1003849.ref013
  article-title: The safety of combined triple drug therapy with ivermectin, diethylcarbamazine and albendazole in the neglected tropical diseases co-endemic setting of Fiji: A cluster randomised trial
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0008106
  contributor:
    fullname: M Hardy
– ident: pmed.1003849.ref011
– ident: pmed.1003849.ref015
– volume: 9
  start-page: e0003452
  issue: 3
  year: 2015
  ident: pmed.1003849.ref004
  article-title: Scabies and impetigo prevalence and risk factors in Fiji: a national survey
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0003452
  contributor:
    fullname: L Romani
– ident: pmed.1003849.ref017
– volume: 373
  start-page: 2305
  issue: 24
  year: 2015
  ident: pmed.1003849.ref005
  article-title: Mass Drug Administration for Scabies Control in a Population with Endemic Disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1500987
  contributor:
    fullname: L Romani
– volume: 33
  start-page: 869
  issue: 5
  year: 2012
  ident: pmed.1003849.ref018
  article-title: Comparison of methods for estimating the intraclass correlation coefficient for binary responses in cancer prevention cluster randomized trials
  publication-title: Contemp Clin Trials
  doi: 10.1016/j.cct.2012.05.004
  contributor:
    fullname: S Wu
– volume: 70
  start-page: 1591
  issue: 8
  year: 2020
  ident: pmed.1003849.ref008
  article-title: Prevalence of Scabies and Impetigo 3 Years After Mass Drug Administration With Ivermectin and Azithromycin
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciz444
  contributor:
    fullname: M Marks
– volume: 19
  start-page: 510
  issue: 5
  year: 2019
  ident: pmed.1003849.ref007
  article-title: Efficacy of mass drug administration with ivermectin for control of scabies and impetigo, with coadministration of azithromycin: a single-arm community intervention trial
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(18)30790-4
  contributor:
    fullname: L Romani
– volume: 68
  start-page: 927
  issue: 6
  year: 2019
  ident: pmed.1003849.ref019
  article-title: Randomized Trial of Community Treatment With Azithromycin and Ivermectin Mass Drug Administration for Control of Scabies and Impetigo
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciy574
  contributor:
    fullname: M Marks
– volume: 13
  start-page: e0007635
  issue: 8
  year: 2019
  ident: pmed.1003849.ref021
  article-title: The diagnosis of scabies by non-expert examiners: A study of diagnostic accuracy
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0007635
  contributor:
    fullname: MH Osti
– ident: pmed.1003849.ref002
SSID ssj0029090
Score 2.4710002
Snippet Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug...
Background Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass...
BACKGROUNDScabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug...
In a cluster randomized trial, Myra Hardy and colleagues, compare mass drug administration of one-dose and two-dose ivermectin-based treatment for community...
BackgroundScabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass drug...
Background Scabies is a neglected tropical disease hyperendemic to many low- and middle-income countries. Scabies can be successfully controlled using mass...
SourceID plos
doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e1003849
SubjectTerms Adolescent
Adult
Aged
Albendazole
Biology and Life Sciences
Child
Child, Preschool
Community health services
Consent
Dosage and administration
Dose-Response Relationship, Drug
Drug dosages
Drug therapy
Earth Sciences
Female
Fiji - epidemiology
Filariasis
Geography
Households
Humans
Impetigo - epidemiology
Infant
Infection control
Islands
Ivermectin
Ivermectin - administration & dosage
Ivermectin - therapeutic use
Male
Medicine and Health Sciences
Methods
Middle Aged
Monte Carlo simulation
Parasitic diseases
Permethrin
Residence Characteristics
Risk Factors
Scabies
Scabies - drug therapy
Scabies - epidemiology
Scabies - prevention & control
Skin
Tropical diseases
Young Adult
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQHhAXRHk1UMAgBKfQteO8uC2IqiC1SJSi3iw_C1KVrJrsgX_PjONEG7QSPXCL4i-JMjP2zCTjbwh5bXLtK6ZKSHLyPBWGYSN3sGVrsGTRecZDu7eT0-L4XHy5yC-2Wn1hTdhADzwI7lBz4Z0NjeMgc1GuKsGDqVpXQmifFT6svks-JlMx1aqX4esK8o-ljJdl3DSXleww6ujdGrwN1ghkFfJobjmlwN0_rdCL9VXb7Qo__66i3HJLR_fI3RhP0tXwHnvklmvuk9sn8Y_5A3IWd4D0v2msSqddP9JDUIhYaWeUhuP3dEXN1QZ5Eyj4L9uCAThLG_xc68FMW-xyR0OTj4fk_OjT94_HaWykkJqyEH1aWGY4TDzIjfJcgcvX4LpqpQpkIjbWQ0rhuNagnKoQjCsNUZFloF7lua98nT0iC3ic2ycUwqHCCpMrK6xQOtPWQEC1LAEI89lnCUlHScr1wJchw0-zEvKMQSQSJS-j5BPyAcU9YZHtOpwAG5DRBuS_bCAhL1BZctg6Os1ZuSoqZMthdZWQVwGBjBcNltRcqk3Xyc9ff9wAdHZ6E9C3GehtBPkWdGpU3OsAMkS6rRnyzQx5OZCN7wIezIBgBGY2vI-GOsq4kxx59JHfTcCVo_HuHn45DeNNseiuce0GMHldiByblCXk8WDrk54yAYkmrOYJKWezYKbI-Ujz62egL68wqBbsyf_Q_FNyh2ORUajLPCCL_nrjnkGU2OvnYUH4Axd5Yig
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZgkRAXxLuBAgYhOIXWjhMnXNCCqApSi0Qp2pvlR7wgVcnSZA_8e2YcZ9ugFepttf72oXl4ZpzxN4S8srnxJdMSipw8T4VlOMgdbNlZbFmsPeNh3NvRcXF4Kr4s8kU8cOtiW-W4J4aN2rUWz8j3OPKCI1-VeL_6neLUKHy6GkdoXCc3GIdQDvYsFxcFV7UfzliQhSxlXMp4dS6TbC9q6u0KYg52CmQlsmleCk2BwX-zT89WZ223LQn9t5fyUnA6uENux6ySzgczuEuu1c09cvMoPje_T07iPZD-D4296bTrR5IICnkr7aw28PodnVN7tkb2BApRzLVgBrWjDR7aejDWFmfd0TDq4wE5Pfj0_eNhGscppFYWok8LxywH94MKKc81BH4DAazSukA-Yus8FBY1NwZUVBaCcW1AoI6BkrXnvvRV9pDM4OfqHUIhKSqcsLl2wgltMuMspFX7EoDg1T5LSDpKUq0G1gwVHp1JqDYGkSiUvIqST8gHFPcGi5zX4Y32fKmiCynDha9dGCEINayuSwm5jK5MKYTxWeET8hyVpYYLpBvPVfOiRM4cVpUJeRkQyHvRYGPNUq-7Tn3--uMKoJPjq4C-TUBvIsi3oFOr440HkCGSbk2QryfI5UA5vg24OwGCEdjJ8g4a6ijjTl14DXxyNN7tyy82y_il2HrX1O0aMHlViBxHlSXk0WDrGz1lAspN2NMTIideMFHkdKX59TOQmJeYWgv2-P9_6wm5xbGJKPRd7pJZf76un0IW2JtnwdX_AvqkWdY
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3ri9QwEA_nCuIX8X3VU6OIfupxSdOXILKKxynsCZ4r9y3k0ewJy3bddsH7751J02Jlxfu2NL92YR6dmWbyG0JemlS7gqkcipw0jYVhOMgdbNkabFmsHON-3NvsNDuZi8_n6fke6We2BgE2O0s7nCc13ywPf_28fAcO_9ZPbchZf9PhGuIH7vonhSivkescYiM2ec3EsK_AyyP_1QV5yWLG8zwcpvvXU0bBynP6D2_uyXpZN7vS0r-7K_8IV8e3ya2QZ9JpZxh3yF61uktuzMJO-j1yFk6GtJc0dKvTpu1pIyhksrQxSsPvN3RKzXKLfAoU4pqtwTAqS1f4GdeB-dY4_Y764R_3yfz447cPJ3EYsBCbPBNtnFlmODgk1ExpqiAV0BDSSqUyZCg21kGpUXGtQWlFJhhXGrIly0DtynFXuDJ5QCbwd9U-oZAmZVaYVFlhhdKJtgYSraMcgODnLolI3EtSrjseDek303KoPzqRSJS8DJKPyHsU94BFFmx_od4sZHAqqblwlfVDBaGqVVWRQ3ajSl0IoV2SuYg8Q2XJ7kjp4MtymhXIosPKIiIvPAKZMFbYarNQ26aRn758vwLo7PQqoK8j0OsAcjXo1KhwBgJkiDRcI-SrEXLRkZDvAh6MgGAEZrS8j4bay7iRHPn1kfdNwJ298e5efj4s40OxGW9V1VvApGUmUhxeFpGHna0PekoEFKDwlo9IPvKCkSLHK6sfF57WvMBkW7BH_1XaY3KTY2eRb8Y8IJN2s62eQGrY6qfe238DbnZg2g
  priority: 102
  providerName: Scholars Portal
Title Community control strategies for scabies: A cluster randomised noninferiority trial
URI https://www.ncbi.nlm.nih.gov/pubmed/34758017
https://www.proquest.com/docview/2610942284
https://search.proquest.com/docview/2596458602
https://pubmed.ncbi.nlm.nih.gov/PMC8612541
https://doaj.org/article/b24fed87401446ae87901a9b844bf36f
http://dx.doi.org/10.1371/journal.pmed.1003849
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe2IiFeEN8LjGIQgqe0TeLECW_dtGkgtUwbQ32L_BF3k7qkWtIH_nvuHKcQ1IeJlyqqf0kr353vzjn_jpCPKpYmDQSHJCeOfaYCbOQOuqwVliwWJghtu7fZPDm7Yt8W8WKPxN1ZGFu0r-TNqFzdjsqba1tbub5V465ObHw-O07RLbNgvE_2wf12KbrLsrKJ3VhB6jE_CDl35-UiHoydeEZrcDRYHhClDFlDIwZB88S2LPvjmiyD_3adHqxXVb0rCP23lvIv53T6hDx2USWdtv_-Kdkrymfk4cy9N39OLt05kOYXdbXptG46kggKcSutlZBw_YVOqVptkD2BghfTFahBoWmJm7YGlLXCXnfUtvp4Qa5OT34cn_munYKveMIaP9GBCsH8IEOKYwGOX4IDy4RIkI9YaQOJRRFKCSJKExaEQkJspAMQsjChSU0WvSQD-LnigFAIihLNVCw000zISGoFYdWEAxCs2kQe8buZzNcta0ZuX51xyDbaKclRCLkTgkeOcLq3WOS8tl9Ud8vcST6XITOFti0EIYcVRcohlhGZTBmTJkqMR96hsPL2AOnWcvNpkiJnTpClHvlgEch7UWJhzVJs6jr_-v3nPUCX8_uALnqgzw5kKpCpEu7EA8whkm71kJ96yGVLOb4LeNgDghKo3vABKmo3x3UeIps-srwxuLNT3t3D77fD-FAsvSuLagOYOEtYjK3KPPKq1fWtnDrL8QjvWUFPkP0RsGlLYu5s-PV_3_mGPAqxvsiWZB6SQXO3Kd5CgNjIISwLCz4kD45O5ucXQ7vNAp8zlg7tUvEbDmNnJQ
link.rule.ids 230,314,727,780,784,864,885,2102,2221,12056,21388,24318,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793,73745,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Zb9QwELZgKwEviLuBQg1C8BRaJ87FC9qiVlvoLqiX-mb5iBekKlma7AP_nhnHGxq0Qn1brb89NIdnxhl_Q8hbnSibM5lBkZMkIdcMB7mDLRuNLYulZZEb9zadpZMz_uUiufAHbo1vq1ztiW6jNrXGM_KdCHnBka-Kf1r8CnFqFD5d9SM0bpMNZE5PRmRjb3_2_bgvuYpdd8qCPGQhi7LMX56LM7bjdfVhAVEHewXiHPk0rwUnx-Hf79SjxWXdrEtD_-2mvBaeDh6Q-z6vpOPOEB6SW2X1iNyZ-ifnj8mJvwnS_qa-O5027YomgkLmShstFbz-SMdUXy6RP4FCHDM1GEJpaIXHthbMtcZpd9QN-3hCzg72Tz9PQj9QIdRZytswNUxH4IBQIyWJhNCvIIQVUqbISKyNhdKijJQCJeUpZ5FUkB0ZBmqWNrK5LeKnZAQ_V24SCmlRarhOpOGGSxUroyGx2s0ACH5t44CEK0mKRcebIdzDswzqjU4kAiUvvOQDsofi7rHIeu3eqK_mwjuRUBG3pXFDBKGKlWWeQTYjC5Vzrmyc2oBso7JEd4W0910xTnNkzWFFHpA3DoHMFxW21szlsmnE4bfzG4BOZjcBHQ9A7z3I1qBTLf2dB5Ah0m4NkO8GyHlHOr4OuDUAghHowfImGupKxo346zfwyZXxrl9-3S_jl2LzXVXWS8AkRcoTHFYWkGedrfd6ijkUnLCrByQbeMFAkcOV6ucPR2OeY3LN2fP__61tcndyOj0SR4ezry_IvQhbilwX5hYZtVfL8iXkhK165R3_DzbgXiw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEF5BKlVcEO-6FLogBCeT2F6_uKAUGrVAQ9XSqrfVPryhUmWH2jnw75lZr02NItRblP3y0Dx2Ztaz3xDyRsXSZIFIociJY5-pAAe5gy1rhS2LhQlCO-7taJ4cnLEvF_GF63-qXVtltyfajVpXCs_IxyHygiNfFRsb1xZx_Hn2cfnLxwlS-KTVjdO4SzYgKk7CEdnY258fn_TlVz6xJy7ISeYHYZq6i3RRGoyd3t4vIQJh30CUIbfmjUBl-fz7XXu0vKrqdSnpv52VN0LV7AG573JMOm2N4iG5U5SPyOaRe4r-mJy6WyHNb-o61WnddJQRFLJYWish4fUHOqXqaoVcChRimq7AKApNSzzCNWC6FU6-o3bwxxNyNtv_8enAd8MVfJUmrPETHagQnBHqpTgWkAZICGe5EAmyEyttoMwoQilBYVnCglBIyJR0ACoXJjSZyaOnZAQ_V2wRCilSopmKhWaaCRlJrSDJmqQABB83kUf8TpJ82XJocPsgLYXaoxUJR8lzJ3mP7KG4eywyYNs3qusFdw7FZchMoe1AQahoRZGlkNmIXGaMSRMlxiO7qCzeXift_ZhPkwwZdII888hri0AWjBLtaSFWdc0Pv5_fAnQ6vw3oZAB650CmAp0q4e4_gAyRgmuAfDtALloC8nXAnQEQjEANlrfQUDsZ1_yvD8EnO-Ndv_yqX8YvxUa8sqhWgInzhMU4uMwjz1pb7_UUMSg-YYf3SDrwgoEihyvl5U9LaZ5hos2C7f__rV2yCT7Pvx3Ovz4n90LsLrINmTtk1FyviheQHjbypfP7P9TjYlk
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Community+control+strategies+for+scabies%3A+A+cluster+randomised+noninferiority+trial&rft.jtitle=PLoS+medicine&rft.au=King%2C+Christopher+L&rft.au=Tuicakau%2C+Meciusela&rft.au=Robinson%2C+Leanne+J&rft.au=Engelman%2C+Daniel&rft.date=2021-11-10&rft.pub=Public+Library+of+Science&rft.issn=1549-1277&rft.volume=18&rft.issue=11&rft_id=info:doi/10.1371%2Fjournal.pmed.1003849&rft.externalDBID=n%2Fa&rft.externalDocID=A684564198
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1549-1676&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1549-1676&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1549-1676&client=summon