Tuberculosis drugs’ distribution and emergence of resistance in patient’s lung lesions: A mechanistic model and tool for regimen and dose optimization - Strydom, Natasha; Gupta, Sneha V.; Fox, William S.; Via, Laura E.; Bang, Hyeeun; Lee, Myungsun; Eum, Seokyong; Shim, TaeSun; Barry, Clifton E.; Zimmerman, Matthew; Dartois, Véronique; Savic, Radojka M. (PLoS medicine, 2019)
Keywords: Adult; Analysis; Antibacterial agents; Antitubercular agents; Antitubercular Agents - administration & dosage; Antitubercular Agents - pharmacokinetics; Bacterial infections; Bioengineering; Biology and Life Sciences; Care and treatment; Cavitation; Clinical trials; Clofazimine; Computer simulation; Decision Support Techniques; Disease Progression; Dosage; Drug Administration Schedule; Drug Dosage Calculations; Drug dosages; Drug resistance; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Drug wholesalers; Drugs; Exposure; Female; Humans; Immunology; Infections; Isoniazid; Isoniazid - administration & dosage; Isoniazid - pharmacokinetics; Kanamycin; Kanamycin - administration & dosage; Kanamycin - pharmacokinetics; Laboratories; Linezolid; Linezolid - administration & dosage; Linezolid - pharmacokinetics; Lung - drug effects; Lung - metabolism; Lung - pathology; Lung diseases; Lungs; Male; Medical research; Medicine and Health Sciences; Microbial drug resistance; Microbiology; Middle Aged; Moxifloxacin; Mycobacterium infections; Optimization; Patients; Pharmacodynamics; Pharmacokinetics; Population studies; Public health; Pulmonary lesions; Pyrazinamide; Pyrazinamide - administration & dosage; Pyrazinamide - pharmacokinetics; Retrospective Studies; Rifampin; Rifampin - administration & dosage; Rifampin - pharmacokinetics; Rifapentine; Risk factors; Software; Stochasticity; Surgery; Tissue Distribution; Treatment Failure; Treatment outcome; Tuberculosis; Tuberculosis patients; Tuberculosis, Multidrug-Resistant - etiology; Tuberculosis, Multidrug-Resistant - metabolism; Tuberculosis, Multidrug-Resistant - pathology; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - metabolism; Tuberculosis, Pulmonary - pathology; Vascularization; Web site management software; Young Adult; South Korea; San Francisco California; California; United States--US; Maryland; New Jersey