Power and Predictive Accuracy of Polygenic Risk Scores

• Published in: PLoS genetics Vol. 9; no. 3; p. e1003348
• Main Author: Dudbridge, Frank
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2013; Public Library of Science (PLoS)
• Subjects: Accuracy; Biology; Disease; Estimates; Genome-Wide Association Study; Genomics; Humans; Liability; Linear Models; Mathematics; Mean square errors; Medical research; Medicine; Models, Theoretical; Multifactorial Inheritance - genetics; Polymorphism, Single Nucleotide; Population genetics; Quantitative genetics; Quantitative Trait Loci - genetics; Schizophrenia; Studies; United Kingdom
• ISSN: 1553-7404; 1553-7390; 1553-7404
• DOI: 10.1371/journal.pgen.1003348

Polygenic scores have recently been used to summarise genetic effects among an ensemble of markers that do not individually achieve significance in a large-scale association study. Markers are selected using an initial training sample and used to construct a score in an independent replication sampl...