Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution

• Published in: PLoS genetics Vol. 12; no. 2; p. e1005778
• Main Authors: Uchi, Ryutaro, Takahashi, Yusuke, Niida, Atsushi, Shimamura, Teppei, Hirata, Hidenari, Sugimachi, Keishi, Sawada, Genta, Iwaya, Takeshi, Kurashige, Junji, Shinden, Yoshiaki, Iguchi, Tomohiro, Eguchi, Hidetoshi, Chiba, Kenichi, Shiraishi, Yuichi, Nagae, Genta, Yoshida, Kenichi, Nagata, Yasunobu, Haeno, Hiroshi, Yamamoto, Hirofumi, Ishii, Hideshi, Doki, Yuichiro, Iinuma, Hisae, Sasaki, Shin, Nagayama, Satoshi, Yamada, Kazutaka, Yachida, Shinichi, Kato, Mamoru, Shibata, Tatsuhiro, Oki, Eiji, Saeki, Hiroshi, Shirabe, Ken, Oda, Yoshinao, Maehara, Yoshihiko, Komune, Shizuo, Mori, Masaki, Suzuki, Yutaka, Yamamoto, Ken, Aburatani, Hiroyuki, Ogawa, Seishi, Miyano, Satoru, Mimori, Koshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2016; Public Library of Science (PLoS)
• Subjects: Aged; Aged, 80 and over; Aging - genetics; Biological Evolution; Biology and life sciences; Cancer metastasis; Class I Phosphatidylinositol 3-Kinases; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; CpG Islands; DNA Methylation; Epigenesis, Genetic; Evolutionary adaptation; Exome; Female; Founder Effect; Gene mutation; Genetic aspects; Health aspects; Humans; Male; Medical research; Medicine and Health Sciences; Middle Aged; Models, Biological; Mutation; Phosphatidylinositol 3-Kinases - genetics; Polymorphism, Single Nucleotide; Research and Analysis Methods; Studies

Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor heterogeneity is observed,...