Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

• Published in: PLoS genetics Vol. 11; no. 5; p. e1005190
• Main Authors: Ates, Louis S, Ummels, Roy, Commandeur, Susanna, van de Weerd, Robert, van der Weerd, Robert, Sparrius, Marion, Weerdenburg, Eveline, Alber, Marina, Kalscheuer, Rainer, Piersma, Sander R, Abdallah, Abdallah M, Abd El Ghany, Moataz, Abdel-Haleem, Alyaa M, Pain, Arnab, Jiménez, Connie R, Bitter, Wilbert, Houben, Edith N G
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2015; Public Library of Science (PLoS)
• Subjects: Ampicillin - pharmacology; ATPases; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Cell Membrane Permeability; Chromatography, Liquid; Data processing; DNA Transposable Elements; DNA, Bacterial - genetics; Drug Resistance, Bacterial; Experiments; Fatty acids; Gene expression; Gene Expression Regulation, Bacterial; Genetic aspects; Identification and classification; Lipids; Mutation; Mycobacteria; Mycobacterium bovis - genetics; Mycobacterium bovis - metabolism; Mycobacterium marinum - genetics; Mycobacterium marinum - metabolism; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - metabolism; Permeability; Physiological aspects; Protein binding; Proteins; Sequence Analysis, DNA; Tandem Mass Spectrometry; Tuberculosis; Type VII Secretion Systems - genetics; Type VII Secretion Systems - metabolism

Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across their unusual cell envelope. One of these systems, ESX-5, is only present in slow-growing mycobacteria and responsible for the secretion of multiple substrates. However, the role of ESX-5 substrates in growth...