Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types

• Published in: PLoS genetics Vol. 9; no. 4; p. e1003464
• Main Authors: Giacomini, Craig P, Sun, Steven, Varma, Sushama, Shain, A Hunter, Giacomini, Marilyn M, Balagtas, Jay, Sweeney, Robert T, Lai, Everett, Del Vecchio, Catherine A, Forster, Andrew D, Clarke, Nicole, Montgomery, Kelli D, Zhu, Shirley, Wong, Albert J, van de Rijn, Matt, West, Robert B, Pollack, Jonathan R
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2013; Public Library of Science (PLoS)
• Subjects: Biology; Breast cancer; Cancer; Colorectal cancer; Deoxyribonucleic acid; DNA; Gene Fusion; Genes; Genetic aspects; Genetic transcription; Genomes; Genomics; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Medical research; Medicine; Melanoma; Oncogene Proteins, Fusion - genetics; Physiology, Pathological; Prostate cancer; Protein-Tyrosine Kinases - genetics; Proteins; Proto-Oncogene Proteins - genetics; Stomach cancer; United States

Gene fusions, like BCR/ABL1 in chronic myelogenous leukemia, have long been recognized in hematologic and mesenchymal malignancies. The recent finding of gene fusions in prostate and lung cancers has motivated the search for pathogenic gene fusions in other malignancies. Here, we developed a "b...