Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase

• Published in: PLoS genetics Vol. 9; no. 9; p. e1003736
• Main Authors: Lada, Artem G, Stepchenkova, Elena I, Waisertreiger, Irina S R, Noskov, Vladimir N, Dhar, Alok, Eudy, James D, Boissy, Robert J, Hirano, Masayuki, Rogozin, Igor B, Pavlov, Youri I
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2013; Public Library of Science (PLoS)
• Subjects: Adenine - analogs & derivatives; Adenine - pharmacology; Animals; APOBEC-1 Deaminase; Cytidine Deaminase - genetics; Cytidine Deaminase - metabolism; Cytosine Deaminase - genetics; Diploidy; Genes; Genetic aspects; Genetic research; Genome, Fungal - drug effects; Genome-wide association studies; Genomics; Government grants; Haploidy; Humans; Lampreys - metabolism; Mutagenesis; Mutagenesis - drug effects; Mutation; Mutation - genetics; Mutation Rate; Ploidy; Saccharomyces cerevisiae - drug effects; Yeast; Yeast fungi; United States

Genetic information should be accurately transmitted from cell to cell; conversely, the adaptation in evolution and disease is fueled by mutations. In the case of cancer development, multiple genetic changes happen in somatic diploid cells. Most classic studies of the molecular mechanisms of mutagen...