Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics Study

• Published in: PLoS medicine Vol. 8; no. 9; p. e1001093
• Main Authors: Desai, Keyur H., Tan, Chuen Seng, Leek, Jeffrey T., Maier, Ronald V., Tompkins, Ronald G., Storey, John D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2011; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Antigen Presentation; Biology; Care and treatment; Female; Gene expression; Gene Expression Regulation; Genes, MHC Class II; Genomics; Humans; Immune system; Inflammation; Inflammation - complications; Inflammation - immunology; Leukocytes - cytology; Leukocytes - immunology; Longitudinal Studies; Male; MAP Kinase Signaling System; Mathematics; Medicine; Middle Aged; Multiple Organ Failure - etiology; Multiple Organ Failure - immunology; Multiple Organ Failure - physiopathology; Oligonucleotide Array Sequence Analysis; Principal components analysis; Prognosis; Prospective Studies; Statistical analysis; Statistical methods; Studies; Trauma; Wounds and injuries; Wounds and Injuries - complications; Wounds and Injuries - genetics; Wounds and Injuries - immunology; Wounds and Injuries - physiopathology; Young Adult; United States; United States > US; Genes, MHC Class II; Prospective Studies; Oligonucleotide Array Sequence Analysis; Humans; Middle Aged; Gene Expression Regulation; Male; Inflammation; Leukocytes; MAP Kinase Signaling System; Multiple Organ Failure; Wounds & Injuries; Young Adult; Antigen Presentation; Adolescent; Adult; Female; Longitudinal Studies

Trauma is the number one killer of individuals 1-44 y of age in the United States. The prognosis and treatment of inflammatory complications in critically injured patients continue to be challenging, with a history of failed clinical trials and poorly understood biology. New approaches are therefore...