NMR Metabolomic Analysis of Fecal Water from Subjects on a Vegetarian Diet

A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from huma...

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Published inBiological & Pharmaceutical Bulletin Vol. 31; no. 6; pp. 1192 - 1198
Main Authors Rafter, Joseph James, Verpoorte, Robert, Karlsson, Pernilla Christina, Pettersson, Jenny, Choi, Young Hae, Bohlin, Lars
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.06.2008
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
colon cancer
Cyclooxygenase 2 Inhibitors - metabolism
Cyclooxygenase 2 Inhibitors - pharmacology
cyclooxygenase-2 inhibitor
Diet, Vegetarian
Dinoprostone - analysis
Dinoprostone - metabolism
Fatty Acids - metabolism
Feces - chemistry
HT29 Cells
Humans
Magnetic Resonance Spectroscopy
MEDICIN
MEDICINE
Metabolism
metabolomic
nuclear magnetic resonance
Passive Cutaneous Anaphylaxis
Tissue Extracts - metabolism
Tissue Extracts - pharmacology
vegetarian fecal water
Water - chemistry
Water - metabolism
nuclear magnetic resonance
cyclooxygenase-2 inhibitor
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Abstract A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells. The aim with the present study was to further study the composition of the fecal waters, using NMR spectroscopy and multivariate data analysis, and to trace the COX-2 inhibiting activity. Intact fecal water samples and fractions thereof were analyzed for their ability to inhibit prostaglandin E2 production in the human colon cell line HT-29. The majority of the tested aqueous phases derived from intact fecal water showed ability to inhibit prostaglandin production in cells (13.8±1.34% inhibition, p=0.01). NMR analysis indicated the presence of significant quantities of amino acids and fatty acids. Major metabolites included; acetic acid, butanoic acid, propanoic acid, glutamic acid and alanine. Smaller amounts of glycine and fumaric acid, which are known to have anti-inflammatory and anti-tumorigenic properties, were also detected. This study describes for the first time NMR metabolomic analysis of fecal water from subjects on a vegetarian diet.
AbstractList A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells. The aim with the present study was to further study the composition of the fecal waters, using NMR spectroscopy and multivariate data analysis, and to trace the COX-2 inhibiting activity. Intact fecal water samples and fractions thereof were analyzed for their ability to inhibit prostaglandin E2 production in the human colon cell line HT-29. The majority of the tested aqueous phases derived from intact fecal water showed ability to inhibit prostaglandin production in cells (13.8±1.34％ inhibition, p＝0.01). NMR analysis indicated the presence of significant quantities of amino acids and fatty acids. Major metabolites included；acetic acid, butanoic acid, propanoic acid, glutamic acid and alanine. Smaller amounts of glycine and fumaric acid, which are known to have anti-inflammatory and anti-tumorigenic properties, were also detected. This study describes for the first time NMR metabolomic analysis of fecal water from subjects on a vegetarian diet.
A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells. The aim with the present study was to further study the composition of the fecal waters, using NMR spectroscopy and multivariate data analysis, and to trace the COX-2 inhibiting activity. Intact fecal water samples and fractions thereof were analyzed for their ability to inhibit prostaglandin E2 production in the human colon cell line HT-29. The majority of the tested aqueous phases derived from intact fecal water showed ability to inhibit prostaglandin production in cells (13.8+/-1.34% inhibition, p=0.01). NMR analysis indicated the presence of significant quantities of amino acids and fatty acids. Major metabolites included; acetic acid, butanoic acid, propanoic acid, glutamic acid and alanine. Smaller amounts of glycine and fumaric acid, which are known to have anti-inflammatory and anti-tumorigenic properties, were also detected. This study describes for the first time NMR metabolomic analysis of fecal water from subjects on a vegetarian diet.
A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells. The aim with the present study was to further study the composition of the fecal waters, using NMR spectroscopy and multivariate data analysis, and to trace the COX-2 inhibiting activity. Intact fecal water samples and fractions thereof were analyzed for their ability to inhibit prostaglandin E2 production in the human colon cell line HT-29. The majority of the tested aqueous phases derived from intact fecal water showed ability to inhibit prostaglandin production in cells (13.8±1.34% inhibition, p=0.01). NMR analysis indicated the presence of significant quantities of amino acids and fatty acids. Major metabolites included; acetic acid, butanoic acid, propanoic acid, glutamic acid and alanine. Smaller amounts of glycine and fumaric acid, which are known to have anti-inflammatory and anti-tumorigenic properties, were also detected. This study describes for the first time NMR metabolomic analysis of fecal water from subjects on a vegetarian diet.
A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells. The aim with the present study was to further study the composition of the fecal waters, using NMR spectroscopy and multivariate data analysis, and to trace the COX-2 inhibiting activity. Intact fecal water samples and fractions thereof were analyzed for their ability to inhibit prostaglandin E2 production in the human colon cell line HT-29. The majority of the tested aqueous phases derived from intact fecal water showed ability to inhibit prostaglandin production in cells (13.8+/-1.34% inhibition, p=0.01). NMR analysis indicated the presence of significant quantities of amino acids and fatty acids. Major metabolites included; acetic acid, butanoic acid, propanoic acid, glutamic acid and alanine. Smaller amounts of glycine and fumaric acid, which are known to have anti-inflammatory and anti-tumorigenic properties, were also detected. This study describes for the first time NMR metabolomic analysis of fecal water from subjects on a vegetarian diet.A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells. The aim with the present study was to further study the composition of the fecal waters, using NMR spectroscopy and multivariate data analysis, and to trace the COX-2 inhibiting activity. Intact fecal water samples and fractions thereof were analyzed for their ability to inhibit prostaglandin E2 production in the human colon cell line HT-29. The majority of the tested aqueous phases derived from intact fecal water showed ability to inhibit prostaglandin production in cells (13.8+/-1.34% inhibition, p=0.01). NMR analysis indicated the presence of significant quantities of amino acids and fatty acids. Major metabolites included; acetic acid, butanoic acid, propanoic acid, glutamic acid and alanine. Smaller amounts of glycine and fumaric acid, which are known to have anti-inflammatory and anti-tumorigenic properties, were also detected. This study describes for the first time NMR metabolomic analysis of fecal water from subjects on a vegetarian diet.
Author Pettersson, Jenny
Karlsson, Pernilla Christina
Rafter, Joseph James
Verpoorte, Robert
Choi, Young Hae
Bohlin, Lars
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  fullname: Bohlin, Lars
  organization: Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University
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Cites_doi 10.1136/jcp.56.9.651
10.1016/j.chroma.2004.08.117
10.1111/j.1365-2133.2005.06728.x
10.1016/S0065-2776(08)60430-7
10.1006/jsre.1998.5279
10.1093/ajcn/45.3.559
10.1093/carcin/15.5.1049
10.1016/S0165-6147(02)00043-3
10.1002/jlac.18410380102
10.1016/j.biopha.2006.07.084
10.1054/clnu.2002.0627
10.1097/00004836-200603000-00015
10.1038/nrc1189
10.1021/jf0486141
10.1056/NEJMp048288
10.1079/BJN19980087
10.1093/jn/135.1.129
10.1207/s15327914nc5201_5
10.1093/ajcn/66.5.1277
10.1021/np000620d
10.1016/j.bbrc.2004.03.066
10.1053/gast.2001.21188
10.1016/j.chroma.2005.11.114
10.1021/np050535b
10.1093/jn/132.6.1376
10.1093/carcin/20.6.969
10.1039/b314316n
10.1007/s000180050030
10.1007/s00394-004-0502-2
10.1093/ajcn/50.5.992
10.1093/ajcn/81.1.268S
10.1093/carcin/21.1.69
10.1207/S15327914NC3601_12
10.1093/jn/133.8.2682
10.1021/np980088i
10.1021/pr060470d
10.1053/gast.2001.23257
10.1016/S1383-5718(00)00113-3
10.1093/carcin/18.12.2353
10.1093/carcin/24.3.385
10.1080/004982599238047
10.1016/j.freeradbiomed.2004.11.020
10.1207/S15327914NC422_6
10.1093/jn/135.10.2343
10.1093/carcin/bgh265
10.1016/S0021-9258(18)35698-9
10.1136/gut.45.5.730
10.1016/j.ab.2003.08.028
10.1080/10715760600771400
10.1017/BJN20061948
10.1586/14737159.4.2.189
10.1093/jn/133.6.1806
10.1079/BJN20031003
10.1079/BJN2002686
10.1093/carcin/20.5.793
10.1093/carcin/20.12.2311
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References 3) Rafter J. J., Child P., Anderson A. M., Alder R., Eng V., Bruce W. R., Am. J. Clin. Nutr., 45, 559—563 (1987).
50) Wong J. M. W., de Souza R., Kendall C. W. C., Emam A., Jenkins D. J. A., J. Clin. Gastroenterol., 40, 235—243 (2006).
42) Jaganath I. B., Mullen W., Edwards C. A., Crozier A., Free Rad. Res., 40, 1035—1046 (2006).
54) Rose M. L., Madren J., Bunzendahl H., Thurman R. G., Carcinogenesis, 20, 793—798 (1999).
41) Aura A. M., Martin-Lopez P., O'Leary K. A., Williamson G., Oksman-Caldentey K.-M., Poutanen K., Santos-Buelga C., Eur. J. Nutr., 44, 133—142 (2005).
59) Lawrence J. R., Peter R., Baxter G. J., Robson J., Graham A. B., Paterson J. R., J. Clin. Pathol., 56, 651—653 (2003).
44) Ringbom T., Huss U., Stenholm Å., Flock S., Skattebøl L., Perera P., Bohlin L., J. Nat. Prod., 64, 745—749 (2001).
53) Roomi M. W., Ivanov V., Kalinovsky T., Niedzwiecki A., Rath M., Oncol. Rep., 13, 421—425 (2005).
27) Nicholson J. K., Lindon J. C., Holmes E., Xenobiotica, 29, 1181—1189 (1999).
33) Calviello G., Di Nicuolo F., Gragnoli S., Piccioni E., Serini S., Maggiano N., Tringali G., Navarra P., Ranelletti F. O., Palozza P., Carcinogenesis, 25, 2303—2310 (2004).
40) Olthof M. R., Hollman C. H., Buijsman M. N. C. P., van Amelsvoort J. M. M., Katan M. B., J. Nutr., 133, 1806—1814 (2003).
51) Tong X., Yin L., Giardina C., Biochem. Biophys. Res. Commun., 317, 463—471 (2004).
43) Gonthier M.-P., Remesy C., Scalbert A., Cheynier V., Souquet J.-M., Poutanen K., Aura A.-M., Biomed. Pharmacother., 60, 536—540 (2006).
61) Solanky K. S., Bailey N. J. C., Beckwith-Hall B. M., Davis A., Bingham S., Holmes E., Nicholson J. K., Cassidy A., Anal. Biochem., 323, 197—204 (2003).
46) Ringbom T., Segura L., Noreen Y., Perera P., Bohlin L., J. Nat. Prod., 61, 1212—1215 (1998).
2) Surh Y.-J., Nat. Rev. Cancer, 3, 768—780 (2003).
62) Mullen W., Boitier A., Stewart A. J., Crozier A., J. Chromatogr. A, 1058, 163—168 (2004).
1) Rafter J., Br. J. Nutr., 88 (Suppl.), S219—S224 (2002).
37) Reddy S., Sanders T. A. B., Owen R. W., Thompson M. H., Br. J. Nutr., 79, 495—500 (1998).
57) Pereira M. A., Barnes L. H., Rassman V. L., Kelloff G. V., Steele V. E., Carcinogenesis, 15, 1049—1054 (1994).
60) Teague C., Holmes E., Maibaum E., Nicholson J., Tang H., Chan Q., Elliot P., Wilson I., Analyst, 129, 259—264 (2004).
32) Glinghammar B., Venturi M., Rowland I. R., Rafter J. J., Am. J. Clin. Nutr., 66, 1277—1282 (1997).
52) Crew T. E., Elder D. J. E., Paraskeva C., Carcinogenesis, 21, 69—77 (2000).
23) Choi Y. H., Sertic S., Kim H. K., Wilson E. G., Michopoulos F., Lefeber A. W. M., Erkelens C., Kricun S. D. P., Verpoorte R., J. Agric. Food Chem., 53, 1237—1245 (2005).
39) Jenner A. M., Rafter J., Halliwell B., Free Radic. Biol. Med., 38, 763—772 (2005).
11) Haza A. I., Glinghammar B., Grandien A., Rafter J., Nutr. Cancer, 36, 79—89 (2000).
24) Choi Y. H., Kim H. K., Linthorst H. J. M., Hollander J. G., Lefeber A. W. M., Erkelens C., Nuzillard J.-M., Verpoorte R., J. Nat. Prod., 69, 742—748 (2006).
13) Karlsson P. C., Huss U., Jenner A., Halliwell B., Bohlin L., Rafter J. J., J. Nutr., 135, 2343—2349 (2005).
20) Fitzgerald G. A., N. Engl. J. Med., 351, 1709—1711 (2004).
22) Eriksson L., Johansson E., Kettaneh-Wold N., Wold S., “Multi- and Megavariate Data Analysis,” Umetrics Academy, Umeå, 2001, pp. 43—70.
26) Lindon J. C., Nicholson J. K., Everett J. R., Ann. Rep. NMR Spectro., 38, 1—88 (1999).
15) Smith W. L., Dewitt D. L., Adv. Immunol., 62, 167—215 (1996).
12) Allinger U. G., Johansson G. K., Gustafsson J. A., Rafter J. J., Am. J. Clin. Nutr., 50, 992—996 (1989).
8) Zeng H., Davis C. D., J. Nutr., 133, 2682—2687 (2003).
7) Lee Y.-K., Hao W., Ho P.-S., Nordling M., Low C.-S., de Kok T. M. C. M., Rafter J., Nutr Cancer, 52, 35—42 (2005).
14) Lee S. H., Soyoola E., Chanmugam P., Hart S., Sun W., Zhong H., Liou S., Simmons D., Hwang D., J. Biol. Chem., 267, 25934—25938 (1992).
35) Palozza P., Serini S., Maggiano N., Tringali G., Navarra P., Ranelletti F. O., Calviello G., J. Nutr., 135, 129—136 (2005).
30) Osswald K., Becker T. W., Grimm M., Jahreis G., Pool-Zobel B. L., Mutat Res., 472, 59—70 (2000).
45) Dommels Y. E. M., Haring M. M. G., Keestra N. G. M., Alink G. M., van Bladeren P. J., van Ommen B., Carcinogenesis, 24, 385—392 (2003).
34) Luceri C., Caderni G., Sanna A., Dolara P., J. Nutr., 132, 1376—1379 (2002).
6) Glinghammar B., Rafter J., Gastroenterology, 120, 401—410 (2001).
9) Venturi M., Hambly R. J., Glinghammar B., Rafter J. J., Rowland I. R., Carcinogenesis, 18, 2353—2359 (1997).
28) Lindon J. C., Holmes E., Nicholson J. K., Expert Rev. Mol. Diagn., 4, 189—199 (2004).
36) Halliwell B., Rafter J., Jenner A., Am. J. Clin. Nutr., 81, 268S—276S (2005).
19) Subbaramaiah K., Dannenberg A. J., Trends Pharmacol. Sci., 24, 96—102 (2003).
49) Kiefer J., Beyer-Sehlmeyer G., Pool-Zobel B. L., Br. J. Nutr., 96, 803—810 (2006).
29) Marchesi J. R., Holmes E., Khan F., Kochhar S., Scanlan P., Shanahan F., Wilson I. D., Wang Y., J. Proteome Res., 6, 546—551 (2007).
5) Dolara P., Caderni G., Salvadori M., Morozzi G., Fabiani R., Cresci A., Orpianesi C., Trallori G., Russo A., Palli D., Nutr. Cancer, 42, 186—190 (2002).
10) Glinghammar B., Holmberg K., Rafter J., Carcinogenesis, 20, 969—976 (1999).
16) Weaver S. A., Russo M. P., Wright K. L., Kolios G., Jobin C., Robertson D. A. F., Ward S. G., Gastroenterology, 120, 1117—1127 (2001).
48) Emenaker N. J., Basson M. D., J. Surg. Res., 76, 41—46 (1998).
47) Llor X., Pons E., Roca A., Alvarez M., Mane J., Fernandez-Banares F., Gassull M. A., Clin. Nutr., 22, 71—79 (2003).
55) Wheeler M. D., Ikejema K., Enomoto N., Stacklewitz R. F., Seabra V., Zhong Z., Yin M., Schemmer P., Rose M. L., Rusyn I., Bradford B., Thurman R. G., Cell Mol. Life Sci., 56, 843—856 (1999).
25) Liang Y.-S., Kim H. K., Lefeber A. W. M., Erkelens C., Choi Y. H., Verpoorte R., J. Chromatogr. A, 1112, 148—155 (2006).
38) Beyer-Sehlmeyer G., Glei M., Hartmann E., Hughes R., Persin C., Böhm V., Rowland I., Schubert R., Jahreis G., Pool-Zobel B. L., Br. J. Nutr., 90, 1057—1070 (2003).
4) Bruce W. R., Giacca A., Medline A., Cancer Epidemiol. Biomarkers Prev., 9, 1271—1279 (2000).
56) Kuroda K., Terao K., Akao M., J. Natl. Cancer Inst., 79, 1047—1051 (1987).
18) Kargman S. L., O'Neill G. P., Vickers P. J., Evans J. F., Mancini J. A., Jothy S., Cancer Res., 55, 2556—2559 (1995).
17) Dimberg J., Samuelsson A., Hugander A., Soderkvist P., Gut, 45, 730—732 (1999).
58) Harries M. J., Chalmers R. J., Griffiths C. E., Br. J. Dermatol., 153, 549—551 (2005).
21) Davies N. M., Jamali F., J. Pharm. Pharm. Sci., 7, 332—336 (2004).
31) Rieger M. A., Parlesak A., Pool-Zobel B. L., Rechkemmer G., Bode C., Carcinogenesis, 20, 2311—2316 (1999).
44
46
KARLSSON PERNILLA C. (13) 2005; 135
Subbaramaiah K., Dannenberg A. J. (19) 2003; 24
Dommels Y. E. M., Haring M. M. G. (45) 2003; 24
Crew T. E., Elder D. J. E., Paraske (52) 2000; 21
Rieger M. A., Parlesak A., Pool-Zob (31) 1999; 20
Haza A. I., Glinghammar B., Grandie (11) 2000; 36
51
Marchesi J. R., Holmes E., Khan F. (29) 2007; 6
Jaganath I. B., Mullen W., Edwards (42) 2006; 40
Rafter J. (1) 2002; 88
55
Kuroda K., Terao K., Akao M. (56) 1987; 79
16
PALOZZA P (35) 2005; 135
Surh Y.-J. (2) 2003; 3
Jenner A. M., Rafter J., Halliwell (39) 2005; 38
Glinghammar B., Rafter J. (6) 2001; 120
Dimberg J., Samuelsson A., Hugander (17) 1999; 45
Bruce W. R., Giacca A., Medline A. (4) 2000; 9
Dolara P., Caderni G., Salvadori M. (5) 2002; 42
60
61
Harries M. J., Chalmers R. J., Grif (58) 2005; 153
20
Glinghammar B., Holmberg K., Rafter (10) 1999; 20
Llor X., Pons E., Roca A., Alvarez (47) 2003; 22
23
24
Glinghammar B., Venturi M., Rowland (32) 1997; 66
25
Pereira M. A., Barnes L. H., Rassma (57) 1994; 15
26
OSSWALD K (30) 2000; 472
27
28
Halliwell B., Rafter J., Jenner A. (36) 2005; 81
MULLEN W (62) 2004; 1058
Lee Y.-K., Hao W., Ho P.-S., Nordli (7) 2005; 52
(14) 1992; 267
Emenaker N. J., Basson M. D. (48) 1998; 76
Wong J. M. W., de Souza R., Kendall (50) 2006; 40
Rose M. L., Madren J., Bunzendahl H (54) 1999; 20
Eriksson L., Johansson E., Kettaneh (22) 2001
LUCERI C (34) 2002; 132
OLTHOF M R (40) 2003; 133
KIEFER JEANNETTE (49) 2006; 96
Lawrence J. R., Peter R., Baxter G. (59) 2003; 56
Davies N. M., Jamali F. (21) 2004; 7
Roomi M. W., Ivanov V., Kalinovsky (53) 2005; 13
37
38
Smith W. L., Dewitt D. L. (15) 1996; 62
Venturi M., Hambly R. J., Glinghamm (9) 1997; 18
Allinger U. G., Johansson G. K., Gu (12) 1989; 50
Rafter J. J., Child P., Anderson A. (3) 1987; 45
ZENG H (8) 2003; 133
(18) 1995; 55
Calviello G., Di Nicuolo F., Gragno (33) 2004; 25
41
43
References_xml – reference: 52) Crew T. E., Elder D. J. E., Paraskeva C., Carcinogenesis, 21, 69—77 (2000).
– reference: 3) Rafter J. J., Child P., Anderson A. M., Alder R., Eng V., Bruce W. R., Am. J. Clin. Nutr., 45, 559—563 (1987).
– reference: 16) Weaver S. A., Russo M. P., Wright K. L., Kolios G., Jobin C., Robertson D. A. F., Ward S. G., Gastroenterology, 120, 1117—1127 (2001).
– reference: 62) Mullen W., Boitier A., Stewart A. J., Crozier A., J. Chromatogr. A, 1058, 163—168 (2004).
– reference: 41) Aura A. M., Martin-Lopez P., O'Leary K. A., Williamson G., Oksman-Caldentey K.-M., Poutanen K., Santos-Buelga C., Eur. J. Nutr., 44, 133—142 (2005).
– reference: 31) Rieger M. A., Parlesak A., Pool-Zobel B. L., Rechkemmer G., Bode C., Carcinogenesis, 20, 2311—2316 (1999).
– reference: 25) Liang Y.-S., Kim H. K., Lefeber A. W. M., Erkelens C., Choi Y. H., Verpoorte R., J. Chromatogr. A, 1112, 148—155 (2006).
– reference: 11) Haza A. I., Glinghammar B., Grandien A., Rafter J., Nutr. Cancer, 36, 79—89 (2000).
– reference: 9) Venturi M., Hambly R. J., Glinghammar B., Rafter J. J., Rowland I. R., Carcinogenesis, 18, 2353—2359 (1997).
– reference: 6) Glinghammar B., Rafter J., Gastroenterology, 120, 401—410 (2001).
– reference: 29) Marchesi J. R., Holmes E., Khan F., Kochhar S., Scanlan P., Shanahan F., Wilson I. D., Wang Y., J. Proteome Res., 6, 546—551 (2007).
– reference: 43) Gonthier M.-P., Remesy C., Scalbert A., Cheynier V., Souquet J.-M., Poutanen K., Aura A.-M., Biomed. Pharmacother., 60, 536—540 (2006).
– reference: 21) Davies N. M., Jamali F., J. Pharm. Pharm. Sci., 7, 332—336 (2004).
– reference: 19) Subbaramaiah K., Dannenberg A. J., Trends Pharmacol. Sci., 24, 96—102 (2003).
– reference: 2) Surh Y.-J., Nat. Rev. Cancer, 3, 768—780 (2003).
– reference: 42) Jaganath I. B., Mullen W., Edwards C. A., Crozier A., Free Rad. Res., 40, 1035—1046 (2006).
– reference: 58) Harries M. J., Chalmers R. J., Griffiths C. E., Br. J. Dermatol., 153, 549—551 (2005).
– reference: 46) Ringbom T., Segura L., Noreen Y., Perera P., Bohlin L., J. Nat. Prod., 61, 1212—1215 (1998).
– reference: 53) Roomi M. W., Ivanov V., Kalinovsky T., Niedzwiecki A., Rath M., Oncol. Rep., 13, 421—425 (2005).
– reference: 56) Kuroda K., Terao K., Akao M., J. Natl. Cancer Inst., 79, 1047—1051 (1987).
– reference: 49) Kiefer J., Beyer-Sehlmeyer G., Pool-Zobel B. L., Br. J. Nutr., 96, 803—810 (2006).
– reference: 36) Halliwell B., Rafter J., Jenner A., Am. J. Clin. Nutr., 81, 268S—276S (2005).
– reference: 60) Teague C., Holmes E., Maibaum E., Nicholson J., Tang H., Chan Q., Elliot P., Wilson I., Analyst, 129, 259—264 (2004).
– reference: 14) Lee S. H., Soyoola E., Chanmugam P., Hart S., Sun W., Zhong H., Liou S., Simmons D., Hwang D., J. Biol. Chem., 267, 25934—25938 (1992).
– reference: 50) Wong J. M. W., de Souza R., Kendall C. W. C., Emam A., Jenkins D. J. A., J. Clin. Gastroenterol., 40, 235—243 (2006).
– reference: 32) Glinghammar B., Venturi M., Rowland I. R., Rafter J. J., Am. J. Clin. Nutr., 66, 1277—1282 (1997).
– reference: 35) Palozza P., Serini S., Maggiano N., Tringali G., Navarra P., Ranelletti F. O., Calviello G., J. Nutr., 135, 129—136 (2005).
– reference: 61) Solanky K. S., Bailey N. J. C., Beckwith-Hall B. M., Davis A., Bingham S., Holmes E., Nicholson J. K., Cassidy A., Anal. Biochem., 323, 197—204 (2003).
– reference: 22) Eriksson L., Johansson E., Kettaneh-Wold N., Wold S., “Multi- and Megavariate Data Analysis,” Umetrics Academy, Umeå, 2001, pp. 43—70.
– reference: 13) Karlsson P. C., Huss U., Jenner A., Halliwell B., Bohlin L., Rafter J. J., J. Nutr., 135, 2343—2349 (2005).
– reference: 47) Llor X., Pons E., Roca A., Alvarez M., Mane J., Fernandez-Banares F., Gassull M. A., Clin. Nutr., 22, 71—79 (2003).
– reference: 20) Fitzgerald G. A., N. Engl. J. Med., 351, 1709—1711 (2004).
– reference: 34) Luceri C., Caderni G., Sanna A., Dolara P., J. Nutr., 132, 1376—1379 (2002).
– reference: 30) Osswald K., Becker T. W., Grimm M., Jahreis G., Pool-Zobel B. L., Mutat Res., 472, 59—70 (2000).
– reference: 37) Reddy S., Sanders T. A. B., Owen R. W., Thompson M. H., Br. J. Nutr., 79, 495—500 (1998).
– reference: 26) Lindon J. C., Nicholson J. K., Everett J. R., Ann. Rep. NMR Spectro., 38, 1—88 (1999).
– reference: 51) Tong X., Yin L., Giardina C., Biochem. Biophys. Res. Commun., 317, 463—471 (2004).
– reference: 55) Wheeler M. D., Ikejema K., Enomoto N., Stacklewitz R. F., Seabra V., Zhong Z., Yin M., Schemmer P., Rose M. L., Rusyn I., Bradford B., Thurman R. G., Cell Mol. Life Sci., 56, 843—856 (1999).
– reference: 8) Zeng H., Davis C. D., J. Nutr., 133, 2682—2687 (2003).
– reference: 28) Lindon J. C., Holmes E., Nicholson J. K., Expert Rev. Mol. Diagn., 4, 189—199 (2004).
– reference: 39) Jenner A. M., Rafter J., Halliwell B., Free Radic. Biol. Med., 38, 763—772 (2005).
– reference: 4) Bruce W. R., Giacca A., Medline A., Cancer Epidemiol. Biomarkers Prev., 9, 1271—1279 (2000).
– reference: 38) Beyer-Sehlmeyer G., Glei M., Hartmann E., Hughes R., Persin C., Böhm V., Rowland I., Schubert R., Jahreis G., Pool-Zobel B. L., Br. J. Nutr., 90, 1057—1070 (2003).
– reference: 40) Olthof M. R., Hollman C. H., Buijsman M. N. C. P., van Amelsvoort J. M. M., Katan M. B., J. Nutr., 133, 1806—1814 (2003).
– reference: 23) Choi Y. H., Sertic S., Kim H. K., Wilson E. G., Michopoulos F., Lefeber A. W. M., Erkelens C., Kricun S. D. P., Verpoorte R., J. Agric. Food Chem., 53, 1237—1245 (2005).
– reference: 45) Dommels Y. E. M., Haring M. M. G., Keestra N. G. M., Alink G. M., van Bladeren P. J., van Ommen B., Carcinogenesis, 24, 385—392 (2003).
– reference: 18) Kargman S. L., O'Neill G. P., Vickers P. J., Evans J. F., Mancini J. A., Jothy S., Cancer Res., 55, 2556—2559 (1995).
– reference: 27) Nicholson J. K., Lindon J. C., Holmes E., Xenobiotica, 29, 1181—1189 (1999).
– reference: 44) Ringbom T., Huss U., Stenholm Å., Flock S., Skattebøl L., Perera P., Bohlin L., J. Nat. Prod., 64, 745—749 (2001).
– reference: 59) Lawrence J. R., Peter R., Baxter G. J., Robson J., Graham A. B., Paterson J. R., J. Clin. Pathol., 56, 651—653 (2003).
– reference: 33) Calviello G., Di Nicuolo F., Gragnoli S., Piccioni E., Serini S., Maggiano N., Tringali G., Navarra P., Ranelletti F. O., Palozza P., Carcinogenesis, 25, 2303—2310 (2004).
– reference: 15) Smith W. L., Dewitt D. L., Adv. Immunol., 62, 167—215 (1996).
– reference: 1) Rafter J., Br. J. Nutr., 88 (Suppl.), S219—S224 (2002).
– reference: 17) Dimberg J., Samuelsson A., Hugander A., Soderkvist P., Gut, 45, 730—732 (1999).
– reference: 48) Emenaker N. J., Basson M. D., J. Surg. Res., 76, 41—46 (1998).
– reference: 12) Allinger U. G., Johansson G. K., Gustafsson J. A., Rafter J. J., Am. J. Clin. Nutr., 50, 992—996 (1989).
– reference: 10) Glinghammar B., Holmberg K., Rafter J., Carcinogenesis, 20, 969—976 (1999).
– reference: 54) Rose M. L., Madren J., Bunzendahl H., Thurman R. G., Carcinogenesis, 20, 793—798 (1999).
– reference: 5) Dolara P., Caderni G., Salvadori M., Morozzi G., Fabiani R., Cresci A., Orpianesi C., Trallori G., Russo A., Palli D., Nutr. Cancer, 42, 186—190 (2002).
– reference: 7) Lee Y.-K., Hao W., Ho P.-S., Nordling M., Low C.-S., de Kok T. M. C. M., Rafter J., Nutr Cancer, 52, 35—42 (2005).
– reference: 24) Choi Y. H., Kim H. K., Linthorst H. J. M., Hollander J. G., Lefeber A. W. M., Erkelens C., Nuzillard J.-M., Verpoorte R., J. Nat. Prod., 69, 742—748 (2006).
– reference: 57) Pereira M. A., Barnes L. H., Rassman V. L., Kelloff G. V., Steele V. E., Carcinogenesis, 15, 1049—1054 (1994).
– volume: 56
  start-page: 651
  issn: 0021-9746
  year: 2003
  ident: 59
  publication-title: J. Clin. Pathol.
  doi: 10.1136/jcp.56.9.651
– volume: 1058
  start-page: 163
  issn: 0021-9673
  issue: 1/2
  year: 2004
  ident: 62
  publication-title: J. Chromatogr. A
  doi: 10.1016/j.chroma.2004.08.117
– volume: 153
  start-page: 549
  issn: 0007-0963
  year: 2005
  ident: 58
  publication-title: Br. J. Dermatol.
  doi: 10.1111/j.1365-2133.2005.06728.x
– volume: 13
  start-page: 421
  issn: 1021-335X
  year: 2005
  ident: 53
  publication-title: Oncol. Rep.
– volume: 62
  start-page: 167
  issn: 0065-2776
  year: 1996
  ident: 15
  publication-title: Adv. Immunol.
  doi: 10.1016/S0065-2776(08)60430-7
– volume: 76
  start-page: 41
  issn: 0022-4804
  year: 1998
  ident: 48
  publication-title: J. Surg. Res.
  doi: 10.1006/jsre.1998.5279
– volume: 45
  start-page: 559
  issn: 0002-9165
  year: 1987
  ident: 3
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/45.3.559
– volume: 15
  start-page: 1049
  year: 1994
  ident: 57
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/15.5.1049
– volume: 24
  start-page: 96
  year: 2003
  ident: 19
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/S0165-6147(02)00043-3
– ident: 26
  doi: 10.1002/jlac.18410380102
– ident: 43
  doi: 10.1016/j.biopha.2006.07.084
– volume: 22
  start-page: 71
  year: 2003
  ident: 47
  publication-title: Clin. Nutr.
  doi: 10.1054/clnu.2002.0627
– volume: 40
  start-page: 235
  issn: 0192-0790
  year: 2006
  ident: 50
  publication-title: J. Clin. Gastroenterol.
  doi: 10.1097/00004836-200603000-00015
– volume: 3
  start-page: 768
  year: 2003
  ident: 2
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1189
– ident: 23
  doi: 10.1021/jf0486141
– ident: 20
  doi: 10.1056/NEJMp048288
– ident: 37
  doi: 10.1079/BJN19980087
– volume: 135
  start-page: 129
  issn: 0022-3166
  issue: 1
  year: 2005
  ident: 35
  publication-title: J. Nutr.
  doi: 10.1093/jn/135.1.129
– volume: 52
  start-page: 35
  issn: 0163-5581
  year: 2005
  ident: 7
  publication-title: Nutr Cancer
  doi: 10.1207/s15327914nc5201_5
– volume: 66
  start-page: 1277
  issn: 0002-9165
  year: 1997
  ident: 32
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/66.5.1277
– ident: 44
  doi: 10.1021/np000620d
– ident: 51
  doi: 10.1016/j.bbrc.2004.03.066
– start-page: 43
  year: 2001
  ident: 22
  publication-title: Multi- and Megavariate Data Analysis
– volume: 79
  start-page: 1047
  year: 1987
  ident: 56
  publication-title: J. Natl. Cancer Inst.
– volume: 120
  start-page: 401
  issn: 0016-5085
  year: 2001
  ident: 6
  publication-title: Gastroenterology
  doi: 10.1053/gast.2001.21188
– volume: 55
  start-page: 2556
  issn: 0008-5472
  issue: 12
  year: 1995
  ident: 18
  publication-title: Cancer Res.
– ident: 25
  doi: 10.1016/j.chroma.2005.11.114
– volume: 7
  start-page: 332
  year: 2004
  ident: 21
  publication-title: J. Pharm. Pharm. Sci.
– ident: 24
  doi: 10.1021/np050535b
– volume: 132
  start-page: 1376
  issn: 0022-3166
  issue: 6
  year: 2002
  ident: 34
  publication-title: J. Nutr.
  doi: 10.1093/jn/132.6.1376
– volume: 20
  start-page: 969
  year: 1999
  ident: 10
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/20.6.969
– ident: 60
  doi: 10.1039/b314316n
– ident: 55
  doi: 10.1007/s000180050030
– ident: 41
  doi: 10.1007/s00394-004-0502-2
– volume: 50
  start-page: 992
  issn: 0002-9165
  year: 1989
  ident: 12
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/50.5.992
– volume: 81
  start-page: 268S
  issn: 0002-9165
  year: 2005
  ident: 36
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/81.1.268S
– volume: 21
  start-page: 69
  year: 2000
  ident: 52
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/21.1.69
– volume: 9
  start-page: 1271
  issn: 1055-9965
  year: 2000
  ident: 4
  publication-title: Cancer Epidemiol. Biomarkers Prev.
– volume: 36
  start-page: 79
  issn: 0163-5581
  year: 2000
  ident: 11
  publication-title: Nutr. Cancer
  doi: 10.1207/S15327914NC3601_12
– volume: 133
  start-page: 2682
  issn: 0022-3166
  issue: 8
  year: 2003
  ident: 8
  publication-title: J. Nutr.
  doi: 10.1093/jn/133.8.2682
– ident: 46
  doi: 10.1021/np980088i
– volume: 6
  start-page: 546
  issn: 1535-3893
  year: 2007
  ident: 29
  publication-title: J. Proteome Res.
  doi: 10.1021/pr060470d
– ident: 16
  doi: 10.1053/gast.2001.23257
– volume: 472
  start-page: 59
  issn: 0027-5107
  issue: 1/2
  year: 2000
  ident: 30
  publication-title: Mutat Res.
  doi: 10.1016/S1383-5718(00)00113-3
– volume: 18
  start-page: 2353
  year: 1997
  ident: 9
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/18.12.2353
– volume: 24
  start-page: 385
  year: 2003
  ident: 45
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/24.3.385
– ident: 27
  doi: 10.1080/004982599238047
– volume: 38
  start-page: 763
  issn: 0891-5849
  year: 2005
  ident: 39
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2004.11.020
– volume: 42
  start-page: 186
  issn: 0163-5581
  year: 2002
  ident: 5
  publication-title: Nutr. Cancer
  doi: 10.1207/S15327914NC422_6
– volume: 135
  start-page: 2343
  issn: 0022-3166
  issue: 10
  year: 2005
  ident: 13
  publication-title: J. Nutr.
  doi: 10.1093/jn/135.10.2343
– volume: 25
  start-page: 2303
  year: 2004
  ident: 33
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgh265
– volume: 267
  start-page: 25934
  issn: 0021-9258
  issue: 36
  year: 1992
  ident: 14
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)35698-9
– volume: 45
  start-page: 730
  issn: 0017-5749
  year: 1999
  ident: 17
  publication-title: Gut
  doi: 10.1136/gut.45.5.730
– ident: 61
  doi: 10.1016/j.ab.2003.08.028
– volume: 40
  start-page: 1035
  issn: 1071-5762
  year: 2006
  ident: 42
  publication-title: Free Rad. Res.
  doi: 10.1080/10715760600771400
– volume: 96
  start-page: 803
  issn: 0007-1145
  issue: 5
  year: 2006
  ident: 49
  publication-title: Br. J. Nutr.
  doi: 10.1017/BJN20061948
– ident: 28
  doi: 10.1586/14737159.4.2.189
– volume: 133
  start-page: 1806
  issn: 0022-3166
  issue: 6
  year: 2003
  ident: 40
  publication-title: J. Nutr.
  doi: 10.1093/jn/133.6.1806
– ident: 38
  doi: 10.1079/BJN20031003
– volume: 88
  start-page: S219
  issn: 0007-1145
  year: 2002
  ident: 1
  publication-title: Br. J. Nutr.
  doi: 10.1079/BJN2002686
– volume: 20
  start-page: 793
  year: 1999
  ident: 54
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/20.5.793
– volume: 20
  start-page: 2311
  year: 1999
  ident: 31
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/20.12.2311
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Snippet A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the...
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SubjectTerms Anti-Inflammatory Agents, Non-Steroidal - pharmacology
colon cancer
Cyclooxygenase 2 Inhibitors - metabolism
Cyclooxygenase 2 Inhibitors - pharmacology
cyclooxygenase-2 inhibitor
Diet, Vegetarian
Dinoprostone - analysis
Dinoprostone - metabolism
Fatty Acids - metabolism
Feces - chemistry
HT29 Cells
Humans
Magnetic Resonance Spectroscopy
MEDICIN
MEDICINE
Metabolism
metabolomic
nuclear magnetic resonance
Passive Cutaneous Anaphylaxis
Tissue Extracts - metabolism
Tissue Extracts - pharmacology
vegetarian fecal water
Water - chemistry
Water - metabolism
Title NMR Metabolomic Analysis of Fecal Water from Subjects on a Vegetarian Diet
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