The inheritance of resistance alleles in multiple sclerosis

• Published in: PLoS genetics Vol. 3; no. 9; pp. 1607 - 1613
• Main Authors: Ramagopalan, Sreeram V, Morris, Andrew P, Dyment, David A, Herrera, Blanca M, DeLuca, Gabriele C, Lincoln, Matthew R, Orton, Sarah M, Chao, Michael J, Sadovnick, A Dessa, Ebers, George C
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2007; Public Library of Science (PLoS)
• Subjects: Alleles; Experiments; Genetic aspects; Genetics; Genetics and Genomics; Genomes; Genotype; Haplotypes; Histocompatibility antigens; HLA Antigens - genetics; HLA histocompatibility antigens; Homo (Human); Humans; Immunology; Linkage Disequilibrium; Medical research; Multiple sclerosis; Multiple Sclerosis - genetics; Neurological Disorders; Risk factors

Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*15 and HLA-DRB1*17-bearing haplotypes and interactions at the HLA-DRB1 locus increase risk of MS but it has taken large samples to identif...