Long-term functional consequences and ongoing cerebral inflammation after subarachnoid hemorrhage in the rat

• Published in: PloS one Vol. 9; no. 6; p. e90584
• Main Authors: Kooijman, Elke, Nijboer, Cora H, van Velthoven, Cindy T J, Mol, Wouter, Dijkhuizen, Rick M, Kesecioglu, Jozef, Heijnen, Cobi J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.03.2014; Public Library of Science (PLoS)
• Subjects: Animals; Biology; Brain; Brain damage; Brain Damage, Chronic - immunology; Cerebral Cortex - immunology; Cerebral Cortex - pathology; Encephalitis - immunology; Encephalitis - physiopathology; IL-1β; Inflammation; Macrophages - immunology; Male; Medicine; Neutrophils - immunology; Psychomotor Disorders - immunology; Rats, Wistar; Recovery of Function; Subarachnoid hemorrhage; Subarachnoid Hemorrhage - immunology; Subarachnoid Hemorrhage - physiopathology; Substantia alba; Tumor necrosis factor

Subarachnoid hemorrhage (SAH) represents a considerable health problem with an incidence of 6-7 per 100.000 individuals per year in Western society. We investigated the long-term consequences of SAH on behavior, neuroinflammation and gray- and white-matter damage using an endovascular puncture model...