New Formulation of Paraquat: A Step Forward but in the Wrong Direction?
There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this...
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| Published in | PLoS medicine Vol. 5; no. 2; p. e58 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
01.02.2008
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1549-1676 1549-1277 1549-1676 |
| DOI | 10.1371/journal.pmed.0050058 |
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| Abstract | There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this new formulation would only be effective if a very high proportion of patients are very close to the borderline between a lethal and non-lethal dose--much lower than the median doses ingested by patients in this study. In the more affluent countries of the world, toxicity prevention by product ban may be achievable, but seems less readily acceptable in the economic margins of subsistence farming. |
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| AbstractList | There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this new formulation would only be effective if a very high proportion of patients are very close to the borderline between a lethal and non-lethal dose--much lower than the median doses ingested by patients in this study. In the more affluent countries of the world, toxicity prevention by product ban may be achievable, but seems less readily acceptable in the economic margins of subsistence farming. The author discusses whether the new paraquat formulation introduced in Sri Lanka is a step forward in reducing deaths from paraquat self-poisoning. There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an alginate that would gel in gastric acid.\n Quantities of paraquat ingested in this study were very substantial, and the overall approach of this new formulation would only be effective if a very high proportion of patients are very close to the borderline between a lethal and non-lethal dose--much lower than the median doses ingested by patients in this study. In the more affluent countries of the world, toxicity prevention by product ban may be achievable, but seems less readily acceptable in the economic margins of subsistence farming. |
| Audience | Academic |
| Author | Bateman, D. Nicholas |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18303945$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_toxrep_2014_06_010 crossref_primary_10_3109_15563650_2011_554420 crossref_primary_10_1080_03650341003787582 crossref_primary_10_1080_15563650_2022_2105709 crossref_primary_10_1016_S0140_6736_17_31961_X crossref_primary_10_3109_15563650_2010_544658 |
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| Copyright | COPYRIGHT 2008 Public Library of Science 2008 D. Nicholas Bateman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Bateman DN (2008) New Formulation of Paraquat: A Step Forward but in the Wrong Direction? PLoS Med 5(2): e58. doi:10.1371/journal.pmed.0050058 2008 D. Nicholas Bateman. 2008 |
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| References | Smith (journal-pmed-0050058-b001) 1987; 6 Dawson (journal-pmed-0050058-b010) 2007; 52 Lin (journal-pmed-0050058-b004) 2006; 34 Bateman (journal-pmed-0050058-b003) 1987; 6 Eddleston (journal-pmed-0050058-b005) 2003; 96 Heylings (journal-pmed-0050058-b007) 2007; 241 Jones (journal-pmed-0050058-b002) 1999; 92 Wilks (journal-pmed-0050058-b006) 2008; 5 Konradsen (journal-pmed-0050058-b009) 2007; 7 3546084 - Hum Toxicol. 1987 Jan;6(1):31-6 18303942 - PLoS Med. 2008 Feb;5(2):e49 17825971 - Toxicology. 2007 Nov 20;241(1-2):1-10 3546087 - Hum Toxicol. 1987 Jan;6(1):57-62 16424716 - Crit Care Med. 2006 Feb;34(2):368-73 10627878 - QJM. 1999 Oct;92(10):573-8 14566036 - QJM. 2003 Nov;96(11):809-24 17691558 - Ceylon Med J. 2007 Jun;52(2):45-7 17257415 - BMC Public Health. 2007;7:13 |
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| Snippet | There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an... The author discusses whether the new paraquat formulation introduced in Sri Lanka is a step forward in reducing deaths from paraquat self-poisoning. There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an... |
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| SubjectTerms | Chemistry, Pharmaceutical Critical Care / Intensive Care Critical Care and Emergency Medicine Drug dosages Emergency Medicine Humans Medicine in Developing Countries Mental Health Mortality Nutrition Paraquat - chemistry Paraquat - poisoning Pharmacology Poisoning Poisons Public Health Public Health and Epidemiology Suicide Suicide, Attempted - prevention & control Suicide, Attempted - trends |
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| Title | New Formulation of Paraquat: A Step Forward but in the Wrong Direction? |
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