Investigation of micellar and interfacial phenomenon of amitriptyline hydrochloride with cationic ester-bonded gemini surfactant mixture in different solvent media

• Published in: PloS one Vol. 15; no. 11; p. e0241300
• Main Author: Abdul Rub, Malik
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.11.2020; Public Library of Science (PLoS)
• Subjects: Agglomeration; Amitriptyline; Amitriptyline - chemistry; Antidepressants; Aqueous solutions; Bioavailability; Biological activity; Cations; Chemical properties; Dichlorides; Drug delivery; Drug delivery systems; Drug interaction; Drugs; Esters - chemistry; Ethane; Fluorescence; Fluorimetry; Fourier transforms; Hydrophobicity; Infrared analysis; Infrared spectroscopy; Interaction parameters; Medicine and Health Sciences; Mental depression; Mental disorders; Micelles; Molecular Conformation; Molecular structure; Mood; Observations; Pharmaceutical sciences; Phase interfaces; Physical Sciences; Pollutants; Saline solutions; Sodium chloride; Solubilization; Solutions; Solvents; Solvents - chemistry; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy; Spectroscopy, Fourier Transform Infrared; Surface active agents; Surface Tension; Surface-Active Agents - chemical synthesis; Surface-Active Agents - chemistry; Surfactants; Thermodynamics; Urea; Ureas; Saudi Arabia

Herein, the interaction among the antidepressant drug amitriptyline hydrochloride (AMT) and a green gemini surfactant, ethane-1, 2-diyl bis(N,N-dimethyl-N-tetradecylammoniumacetoxy) dichloride (14-E2-14), via numerous techniques such as tensiometry, fluorimetry, FT-IR and UV-visible spectroscopy in...