A genome-wide association study identifies protein quantitative trait loci (pQTLs)

• Published in: PLoS genetics Vol. 4; no. 5; p. e1000072
• Main Authors: Melzer, David, Perry, John R B, Hernandez, Dena, Corsi, Anna-Maria, Stevens, Kara, Rafferty, Ian, Lauretani, Fulvio, Murray, Anna, Gibbs, J Raphael, Paolisso, Giuseppe, Rafiq, Sajjad, Simon-Sanchez, Javier, Lango, Hana, Scholz, Sonja, Weedon, Michael N, Arepalli, Sampath, Rice, Neil, Washecka, Nicole, Hurst, Alison, Britton, Angela, Henley, William, van de Leemput, Joyce, Li, Rongling, Newman, Anne B, Tranah, Greg, Harris, Tamara, Panicker, Vijay, Dayan, Colin, Bennett, Amanda, McCarthy, Mark I, Ruokonen, Aimo, Jarvelin, Marjo-Riitta, Guralnik, Jack, Bandinelli, Stefania, Frayling, Timothy M, Singleton, Andrew, Ferrucci, Luigi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2008; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Biochemistry/Protein Chemistry; Biochemistry/Transcription and Translation; Blood Proteins - genetics; Blood Proteins - metabolism; Cardiovascular Disorders; Diabetes and Endocrinology; Female; Gene Dosage; Genetic Linkage; Genetic Variation; Genetics; Genetics and Genomics/Complex Traits; Genetics and Genomics/Functional Genomics; Genetics and Genomics/Gene Expression; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Genome Projects; Genetics and Genomics/Physiogenomics; Genome, Human; Genomics; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Proteins; Quantitative Trait Loci; Studies; Transcription, Genetic

There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and elsewhere in the genome - trans effects. The r...