The Four-Herb Chinese Medicine ANBP Enhances Wound Healing and Inhibits Scar Formation via Bidirectional Regulation of Transformation Growth Factor Pathway

• Published in: PloS one Vol. 9; no. 12; p. e112274
• Main Authors: Hou, Qian, He, Wen-Jun, Hao, Hao-Jie, Han, Qing-Wang, Chen, Li, Dong, Liang, Liu, Jie-Jie, Li, Xiang, Zhang, Ya-Jing, Ma, Ying-Zhi, Han, Wei-Dong, Fu, Xiao-Bing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.12.2014; Public Library of Science (PLoS)
• Subjects: Agrimonia eupatoria; Analgesia; Animal models; Animals; Bone morphogenetic proteins; Boswellia; Cell cycle; Chinese medicine; Chromatography; Cicatrix, Hypertrophic - genetics; Cicatrix, Hypertrophic - pathology; Cicatrix, Hypertrophic - physiopathology; Cicatrix, Hypertrophic - prevention & control; Collagen; Collagen - metabolism; Collagens; Drugs, Chinese Herbal - pharmacology; Ear - pathology; Ear - physiopathology; Eutrophication; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Fibroblasts; Gene expression; Gene Expression Regulation - drug effects; Granulation; Growth factors; Hemostasis; Hemostatics; Herbal medicine; Herbs; Hospitals; Inflammation; Inflammation Mediators - metabolism; Laboratory animals; Medical research; Medicine; Medicine and Health Sciences; mRNA; Nelumbo nucifera; Pain perception; Pathways; Pharmaceuticals; Pollen; Powders; Quality control; Rabbits; Regulation; Scars; Signal transduction; Signal Transduction - drug effects; Skin; Smad protein; Smad Proteins - metabolism; Smad2 protein; Temperature; Traditional Chinese medicine; Transformation; Transforming growth factor; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b1; Transforming growth factors; Trauma; Typha angustifolia; Wound care; Wound healing; Wound Healing - drug effects; Beijing China; China

The four-herb Chinese medicine ANBP is a pulverized mixture of four herbs including Agrimonia Eupatoria (A), Nelumbo Nucifera Gaertn (N), Boswellia Carteri (B) and Pollen Typhae Angustifoliae (P). The combination of the four herbs was first described in Chinese canonical medicine about 2000 years ag...