The Four-Herb Chinese Medicine ANBP Enhances Wound Healing and Inhibits Scar Formation via Bidirectional Regulation of Transformation Growth Factor Pathway
The four-herb Chinese medicine ANBP is a pulverized mixture of four herbs including Agrimonia Eupatoria (A), Nelumbo Nucifera Gaertn (N), Boswellia Carteri (B) and Pollen Typhae Angustifoliae (P). The combination of the four herbs was first described in Chinese canonical medicine about 2000 years ag...
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| Published in | PloS one Vol. 9; no. 12; p. e112274 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Public Library of Science
09.12.2014
Public Library of Science (PLoS) |
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| Abstract | The four-herb Chinese medicine ANBP is a pulverized mixture of four herbs including Agrimonia Eupatoria (A), Nelumbo Nucifera Gaertn (N), Boswellia Carteri (B) and Pollen Typhae Angustifoliae (P). The combination of the four herbs was first described in Chinese canonical medicine about 2000 years ago for treatment of various trauma disorders, such as hemostasis, antiinflammatory, analgesia, and wound healing, etc. However, the precise mechanisms of ANBP are still unclear. In our study, using rabbit ear hypertrophic scar models of full-thickness skin defect, we showed that local ANBP treatment not only significantly enhanced wound healing by relieving inflammation, increasing formation of granulation tissue and accelerating re-epithelialization, but also reduced scar formation by decreasing collagen production, protuberant height and volume of scars, and increasing collagen maturity. We demonstrated that these effects of ANBP are associated with transforming growth factor (TGF)-β1-mediated signalling pathways through Smad-dependent pathways. ANBP treatment significantly increased expression of TGF-β1 and Smad2/3 mRNA at the early stage of wound healing, and led to markedly decrease expression of TGF-β1 and Smad2/3 compared with the control group after 14 days post-wounding. Taken together, our results defined a bidirectional regulation role of ANBP for TGF-β1/Smad pathway in promoting wound healing and alleviating scar formation, which may be an effective therapy for human wounds at the earliest stage. |
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| AbstractList | The four-herb Chinese medicine ANBP is a pulverized mixture of four herbs including Agrimonia Eupatoria (A), Nelumbo Nucifera Gaertn (N), Boswellia Carteri (B) and Pollen Typhae Angustifoliae (P). The combination of the four herbs was first described in Chinese canonical medicine about 2000 years ago for treatment of various trauma disorders, such as hemostasis, antiinflammatory, analgesia, and wound healing, etc. However, the precise mechanisms of ANBP are still unclear. In our study, using rabbit ear hypertrophic scar models of full-thickness skin defect, we showed that local ANBP treatment not only significantly enhanced wound healing by relieving inflammation, increasing formation of granulation tissue and accelerating re-epithelialization, but also reduced scar formation by decreasing collagen production, protuberant height and volume of scars, and increasing collagen maturity. We demonstrated that these effects of ANBP are associated with transforming growth factor (TGF)-β1-mediated signalling pathways through Smad-dependent pathways. ANBP treatment significantly increased expression of TGF-β1 and Smad2/3 mRNA at the early stage of wound healing, and led to markedly decrease expression of TGF-β1 and Smad2/3 compared with the control group after 14 days post-wounding. Taken together, our results defined a bidirectional regulation role of ANBP for TGF-β1/Smad pathway in promoting wound healing and alleviating scar formation, which may be an effective therapy for human wounds at the earliest stage. The four-herb Chinese medicine ANBP is a pulverized mixture of four herbs including Agrimonia Eupatoria (A), Nelumbo Nucifera Gaertn (N), Boswellia Carteri (B) and Pollen Typhae Angustifoliae (P). The combination of the four herbs was first described in Chinese canonical medicine about 2000 years ago for treatment of various trauma disorders, such as hemostasis, antiinflammatory, analgesia, and wound healing, etc. However, the precise mechanisms of ANBP are still unclear. In our study, using rabbit ear hypertrophic scar models of full-thickness skin defect, we showed that local ANBP treatment not only significantly enhanced wound healing by relieving inflammation, increasing formation of granulation tissue and accelerating re-epithelialization, but also reduced scar formation by decreasing collagen production, protuberant height and volume of scars, and increasing collagen maturity. We demonstrated that these effects of ANBP are associated with transforming growth factor (TGF)-β1-mediated signalling pathways through Smad-dependent pathways. ANBP treatment significantly increased expression of TGF-β1 and Smad2/3 mRNA at the early stage of wound healing, and led to markedly decrease expression of TGF-β1 and Smad2/3 compared with the control group after 14 days post-wounding. Taken together, our results defined a bidirectional regulation role of ANBP for TGF-β1/Smad pathway in promoting wound healing and alleviating scar formation, which may be an effective therapy for human wounds at the earliest stage.The four-herb Chinese medicine ANBP is a pulverized mixture of four herbs including Agrimonia Eupatoria (A), Nelumbo Nucifera Gaertn (N), Boswellia Carteri (B) and Pollen Typhae Angustifoliae (P). The combination of the four herbs was first described in Chinese canonical medicine about 2000 years ago for treatment of various trauma disorders, such as hemostasis, antiinflammatory, analgesia, and wound healing, etc. However, the precise mechanisms of ANBP are still unclear. In our study, using rabbit ear hypertrophic scar models of full-thickness skin defect, we showed that local ANBP treatment not only significantly enhanced wound healing by relieving inflammation, increasing formation of granulation tissue and accelerating re-epithelialization, but also reduced scar formation by decreasing collagen production, protuberant height and volume of scars, and increasing collagen maturity. We demonstrated that these effects of ANBP are associated with transforming growth factor (TGF)-β1-mediated signalling pathways through Smad-dependent pathways. ANBP treatment significantly increased expression of TGF-β1 and Smad2/3 mRNA at the early stage of wound healing, and led to markedly decrease expression of TGF-β1 and Smad2/3 compared with the control group after 14 days post-wounding. Taken together, our results defined a bidirectional regulation role of ANBP for TGF-β1/Smad pathway in promoting wound healing and alleviating scar formation, which may be an effective therapy for human wounds at the earliest stage. The four-herb Chinese medicine ANBP is a pulverized mixture of four herbs including Agrimonia Eupatoria (A), Nelumbo Nucifera Gaertn (N), Boswellia Carteri (B) and Pollen Typhae Angustifoliae (P). The combination of the four herbs was first described in Chinese canonical medicine about 2000 years ago for treatment of various trauma disorders, such as hemostasis, antiinflammatory, analgesia, and wound healing, etc. However, the precise mechanisms of ANBP are still unclear. In our study, using rabbit ear hypertrophic scar models of full-thickness skin defect, we showed that local ANBP treatment not only significantly enhanced wound healing by relieving inflammation, increasing formation of granulation tissue and accelerating re-epithelialization, but also reduced scar formation by decreasing collagen production, protuberant height and volume of scars, and increasing collagen maturity. We demonstrated that these effects of ANBP are associated with transforming growth factor (TGF)-β1-mediated signalling pathways through Smad-dependent pathways. ANBP treatment significantly increased expression of TGF-β1 and Smad2/3 mRNA at the early stage of wound healing, and led to markedly decrease expression of TGF-β1 and Smad2/3 compared with the control group after 14 days post-wounding. Taken together, our results defined a bidirectional regulation role of ANBP for TGF-β1/Smad pathway in promoting wound healing and alleviating scar formation, which may be an effective therapy for human wounds at the earliest stage. The four-herb Chinese medicine ANBP is a pulverized mixture of four herbs including Agrimonia Eupatoria (A), Nelumbo Nucifera Gaertn (N), Boswellia Carteri (B) and Pollen Typhae Angustifoliae (P). The combination of the four herbs was first described in Chinese canonical medicine about 2000 years ago for treatment of various trauma disorders, such as hemostasis, antiinflammatory, analgesia, and wound healing, etc. However, the precise mechanisms of ANBP are still unclear. In our study, using rabbit ear hypertrophic scar models of full-thickness skin defect, we showed that local ANBP treatment not only significantly enhanced wound healing by relieving inflammation, increasing formation of granulation tissue and accelerating re-epithelialization, but also reduced scar formation by decreasing collagen production, protuberant height and volume of scars, and increasing collagen maturity. We demonstrated that these effects of ANBP are associated with transforming growth factor (TGF)-[beta]1-mediated signalling pathways through Smad-dependent pathways. ANBP treatment significantly increased expression of TGF-[beta]1 and Smad2/3 mRNA at the early stage of wound healing, and led to markedly decrease expression of TGF-[beta]1 and Smad2/3 compared with the control group after 14 days post-wounding. Taken together, our results defined a bidirectional regulation role of ANBP for TGF-[beta]1/Smad pathway in promoting wound healing and alleviating scar formation, which may be an effective therapy for human wounds at the earliest stage. |
| Audience | Academic |
| Author | Dong, Liang Liu, Jie-Jie Han, Wei-Dong Hao, Hao-Jie Zhang, Ya-Jing Han, Qing-Wang Fu, Xiao-Bing He, Wen-Jun Li, Xiang Chen, Li Hou, Qian Ma, Ying-Zhi |
| AuthorAffiliation | 3 Wound Healing and Cell Biology Laboratory, the First Affiliated Hospital, Chinese PLA General Hospital, Beijing, P. R. China 2 Department of Internal Medicine, Chinese PLA 148th Hospital, Zibo, P. R. China 1 Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, P. R. China Institut national de la santé et de la recherche médicale - Institut Cochin, France |
| AuthorAffiliation_xml | – name: 3 Wound Healing and Cell Biology Laboratory, the First Affiliated Hospital, Chinese PLA General Hospital, Beijing, P. R. China – name: Institut national de la santé et de la recherche médicale - Institut Cochin, France – name: 1 Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, P. R. China – name: 2 Department of Internal Medicine, Chinese PLA 148th Hospital, Zibo, P. R. China |
| Author_xml | – sequence: 1 givenname: Qian surname: Hou fullname: Hou, Qian – sequence: 2 givenname: Wen-Jun surname: He fullname: He, Wen-Jun – sequence: 3 givenname: Hao-Jie surname: Hao fullname: Hao, Hao-Jie – sequence: 4 givenname: Qing-Wang surname: Han fullname: Han, Qing-Wang – sequence: 5 givenname: Li surname: Chen fullname: Chen, Li – sequence: 6 givenname: Liang surname: Dong fullname: Dong, Liang – sequence: 7 givenname: Jie-Jie surname: Liu fullname: Liu, Jie-Jie – sequence: 8 givenname: Xiang surname: Li fullname: Li, Xiang – sequence: 9 givenname: Ya-Jing surname: Zhang fullname: Zhang, Ya-Jing – sequence: 10 givenname: Ying-Zhi surname: Ma fullname: Ma, Ying-Zhi – sequence: 11 givenname: Wei-Dong surname: Han fullname: Han, Wei-Dong – sequence: 12 givenname: Xiao-Bing surname: Fu fullname: Fu, Xiao-Bing |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25489732$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2014 Public Library of Science 2014 Hou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Hou et al 2014 Hou et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: QH WDH XBF. Performed the experiments: QH WJH. Analyzed the data: WJH QH HJH QWH LC LD JJL XL. Contributed reagents/materials/analysis tools: YJZ YZM. Wrote the paper: WJH QH. Competing Interests: The authors have declared that no competing interests exist. helloThese authors contributed equally to this work. |
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| SubjectTerms | Agrimonia eupatoria Analgesia Animal models Animals Bone morphogenetic proteins Boswellia Cell cycle Chinese medicine Chromatography Cicatrix, Hypertrophic - genetics Cicatrix, Hypertrophic - pathology Cicatrix, Hypertrophic - physiopathology Cicatrix, Hypertrophic - prevention & control Collagen Collagen - metabolism Collagens Drugs, Chinese Herbal - pharmacology Ear - pathology Ear - physiopathology Eutrophication Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibroblasts Gene expression Gene Expression Regulation - drug effects Granulation Growth factors Hemostasis Hemostatics Herbal medicine Herbs Hospitals Inflammation Inflammation Mediators - metabolism Laboratory animals Medical research Medicine Medicine and Health Sciences mRNA Nelumbo nucifera Pain perception Pathways Pharmaceuticals Pollen Powders Quality control Rabbits Regulation Scars Signal transduction Signal Transduction - drug effects Skin Smad protein Smad Proteins - metabolism Smad2 protein Temperature Traditional Chinese medicine Transformation Transforming growth factor Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Transforming growth factors Trauma Typha angustifolia Wound care Wound healing Wound Healing - drug effects |
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| Title | The Four-Herb Chinese Medicine ANBP Enhances Wound Healing and Inhibits Scar Formation via Bidirectional Regulation of Transformation Growth Factor Pathway |
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