Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl 3 promoted homocoupling

The use of FeCl 3 resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO 2...

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Published inBeilstein journal of organic chemistry Vol. 7; pp. 1064 - 1069
Main Authors Nagaki, Aiichiro, Uesugi, Yuki, Tomida, Yutaka, Yoshida, Jun-ichi
Format Journal Article
LanguageEnglish
Published 02.08.2011
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Summary:The use of FeCl 3 resulted in a fast homocoupling of aryllithiums, and this enabled its integration with the halogen–lithium exchange reaction of aryl halides in a flow microreactor. This system allows the homocoupling of two aryl halides bearing electrophilic functional groups, such as CN and NO 2 , in under a minute.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.7.122