The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7

• Published in: PLoS biology Vol. 17; no. 1; p. e2006767
• Main Authors: Köhler, Kerstin, Sanchez-Pulido, Luis, Höfer, Verena, Marko, Anika, Ponting, Chris P, Snijders, Ambrosius P, Feederle, Regina, Schepers, Aloys, Boos, Dominik
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.01.2019; Public Library of Science (PLoS)
• Subjects: Biological evolution; Biology and life sciences; Biotechnology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Carrier Proteins - physiology; Cell cycle; Cell Cycle Proteins - metabolism; Cell division; Chromosomes; Computational Biology - methods; Cyclin C; Cyclin C - genetics; Cyclin C - metabolism; Cyclin-dependent kinase 8; Cyclin-Dependent Kinase 8 - genetics; Cyclin-Dependent Kinase 8 - metabolism; Cyclin-Dependent Kinase 8 - physiology; Cyclin-dependent kinases; Cyclin-Dependent Kinases - metabolism; Cyclin-Dependent Kinases - physiology; Deoxyribonucleic acid; Diabetes; DNA; DNA damage; DNA Replication - physiology; DNA topoisomerase (ATP-hydrolysing); DNA-Binding Proteins - metabolism; Domains; Eukaryotes; Firing; Funding; Genes; Genomes; HEK293 Cells; HeLa Cells; Homeostasis; Homology; Humans; Kinases; MDM2 protein; Medical research; Mitosis; Molecular modelling; Phosphorylation; Protein Binding; Proteins; Replication; Replication initiation; Reproduction (copying); Research and Analysis Methods; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Supervision; Transcription; Vertebrates; Yeast; United Kingdom > UK; Scotland; Germany

Accurate genome duplication underlies genetic homeostasis. Metazoan Mdm2 binding protein (MTBP) forms a main regulatory platform for origin firing together with Treslin/TICRR and TopBP1 (Topoisomerase II binding protein 1 (TopBP1)-interacting replication stimulating protein/TopBP1-interacting checkp...