The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration

• Published in: PLoS biology Vol. 19; no. 2; p. e3001122
• Main Authors: Zhou, Ruyuan, Wu, Qirou, Wang, Mengqiu, Irani, Seema, Li, Xiao, Zhang, Qian, Meng, Fansen, Liu, Shengduo, Zhang, Fei, Wu, Liming, Lin, Xia, Wang, Xiaojian, Zou, Jian, Song, Hai, Qin, Jun, Liang, Tingbo, Feng, Xin-Hua, Zhang, Yan Jessie, Xu, Pinglong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.02.2021; Public Library of Science (PLoS)
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Antibiotics; Biology and Life Sciences; Cell Proliferation; Cells, Cultured; Cellular signal transduction; Colitis - pathology; Cytoplasm; Dephosphorylation; Doxycycline; Genetic aspects; Genetic transcription; Health aspects; Humans; Identification and classification; Insects; Intestine; Intestines - physiology; Kinases; Liver; Liver Regeneration - physiology; Localization; Magnesium; Mammals; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Organoids; Phenotypes; Phosphatase; Phosphatases; Phosphorylation; Physiological aspects; Physiological effects; Physiology; Protein phosphatase; Protein Phosphatase 2C - genetics; Protein Phosphatase 2C - metabolism; Proteins; Regeneration; Regeneration - physiology; Regulation; Regulatory mechanisms (biology); Research and Analysis Methods; Serine; Signal Transduction; Signaling; Threonine; Transcription; Transcription Factors - metabolism; Tumor suppressor genes; YAP-Signaling Proteins; Yes-associated protein; China

The Hippo-YAP pathway responds to diverse environmental cues to manage tissue homeostasis, organ regeneration, tumorigenesis, and immunity. However, how phosphatase(s) directly target Yes-associated protein (YAP) and determine its physiological activity are still inconclusive. Here, we utilized an u...