A population genetic interpretation of GWAS findings for human quantitative traits

• Published in: PLoS biology Vol. 16; no. 3; p. e2002985
• Main Authors: Simons, Yuval B., Bullaughey, Kevin, Hudson, Richard R., Sella, Guy
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.03.2018; Public Library of Science (PLoS)
• Subjects: Adaptation; Architecture; Biology and Life Sciences; Body mass; Body mass index; Body size; Demographics; Evolution; Genetic diversity; Genetic drift; Genetic research; Genetic variance; Genetics; Genomes; Heritability; Mathematical models; Mutation; Natural selection; Pleiotropy; Population genetics; Quantitative genetics; Quantitative trait loci; Studies; Variance; New York; Chicago Illinois; United States > US; Europe; Illinois; Africa
• ISSN: 1545-7885; 1544-9173; 1545-7885
• DOI: 10.1371/journal.pbio.2002985

Human genome-wide association studies (GWASs) are revealing the genetic architecture of anthropomorphic and biomedical traits, i.e., the frequencies and effect sizes of variants that contribute to heritable variation in a trait. To interpret these findings, we need to understand how genetic architec...