Safety and immunogenicity study of Multiclade HIV-1 adenoviral vector vaccine alone or as boost following a multiclade HIV-1 DNA vaccine in Africa

• Published in: PloS one Vol. 5; no. 9; p. e12873
• Main Authors: Jaoko, Walter, Karita, Etienne, Kayitenkore, Kayitesi, Omosa-Manyonyi, Gloria, Allen, Susan, Than, Soe, Adams, Elizabeth M, Graham, Barney S, Koup, Richard A, Bailer, Robert T, Smith, Carol, Dally, Len, Farah, Bashir, Anzala, Omu, Muvunyi, Claude M, Bizimana, Jean, Tarragona-Fiol, Tony, Bergin, Philip J, Hayes, Peter, Ho, Martin, Loughran, Kelley, Komaroff, Wendy, Stevens, Gwynneth, Thomson, Helen, Boaz, Mark J, Cox, Josephine H, Schmidt, Claudia, Gilmour, Jill, Nabel, Gary J, Fast, Patricia, Bwayo, Job
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.09.2010; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adenoviridae - genetics; Adenoviridae - immunology; Adenoviruses; Adolescent; Adult; Adults; AIDS; AIDS vaccines; AIDS Vaccines - adverse effects; AIDS Vaccines - immunology; Antibodies; Antibodies, Viral - immunology; Antigens; Biological response modifiers; Deoxyribonucleic acid; DNA; DNA vaccines; Dosage; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Enzyme-linked immunosorbent assay; Epidemiology; gag Gene Products, Human Immunodeficiency Virus - adverse effects; gag Gene Products, Human Immunodeficiency Virus - genetics; gag Gene Products, Human Immunodeficiency Virus - immunology; Genetic research; Genetic Vectors - adverse effects; Genetic Vectors - genetics; Genetic Vectors - immunology; Health aspects; HIV; HIV antigens; HIV infections; HIV Infections - immunology; HIV Infections - prevention & control; HIV Infections - virology; HIV-1 - classification; HIV-1 - genetics; HIV-1 - immunology; Human immunodeficiency virus; Humans; Immune response; Immune response (humoral); Immune system; Immunity; Immunization, Secondary; Immunogenicity; Immunoglobulins; Immunology; Immunology/Immune Response; Infections; Infectious diseases; Infectious Diseases/HIV Infection and AIDS; Interferon; Laboratories; Lymphocytes; Male; Medical research; Middle Aged; Nef protein; pol Gene Products, Human Immunodeficiency Virus - adverse effects; pol Gene Products, Human Immunodeficiency Virus - genetics; pol Gene Products, Human Immunodeficiency Virus - immunology; Priming; Proteins; Public health; Public Health and Epidemiology/Immunization; Randomization; Safety; Safety and security measures; Vaccines; Vaccines, DNA - adverse effects; Vaccines, DNA - immunology; Young Adult; γ-Interferon; New York; San Francisco California; Kenya; United States > US; Maryland

We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env from subtypes A, B and C, given alone or as boost following a DNA plasmid vaccine expressing the same H...