Anabolic exercise in haemodialysis patients: a randomised controlled pilot study

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 5; no. 3; pp. 199 - 207
• Main Authors: Kirkman, Danielle L., Mullins, Paul, Junglee, Naushad A., Kumwenda, Mick, Jibani, Mahdi M., Macdonald, Jamie H.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2014; Springer‐Verlag; John Wiley & Sons, Inc
• Subjects: Atrophy; Authorship; Body composition; Chronic kidney failure; Clinical Nutrition; Fitness training programs; Geriatrics/Gerontology; Haemodialysis; Health services; Hemodialysis; Internal Medicine; Intervention; Kidney diseases; Medicine; Medicine & Public Health; Molecular Medicine; Mortality; Oncology; Original; Original Article; Patients; Pharmacology/Toxicology; Protein synthesis; Proteins; Quality of life; Wasting syndrome; Weight lifting; United Kingdom > UK; Wales; Haemodialysis; Chronic kidney failure; Wasting syndrome; Weight lifting
• DOI: 10.1007/s13539-014-0140-3
• ISSN: 2190-5991

Background The anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high-intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialysis patients. A second aim was to compare any anabolic response to that of healthy participants completing the same program. Methods In a single blind controlled study, 23 haemodialysis patients and 9 healthy individuals were randomly allocated to PRET or an attention control (SHAM) group. PRET completed high-intensity exercise leg extensions using novel equipment. SHAM completed low-intensity lower body stretching activities using ultra light resistance bands. Exercises were completed thrice weekly for 12 weeks, during dialysis in the haemodialysis patients. Outcomes included knee extensor muscle volume by magnetic resonance imaging, knee extensor strength by isometric dynamometer and lower body tests of physical function. Data were analysed by a per protocol method using between-group comparisons. Results PRET elicited a statistically and clinically significant anabolic response in haemodialysis patients (PRET—SHAM, mean difference [95 % CI]: 193[63 to 324] cm 3 ) that was very similar to the response in healthy participants (PRET—SHAM, 169[−41 to 379] cm 3 ). PRET increased strength in both haemodialysis patients and healthy participants. In contrast, PRET only enhanced lower body functional capacity in the healthy participants. Conclusions Intradialytic PRET elicited a normal anabolic and strength response in haemodialysis patients. The lack of a change in functional capacity was surprising and warrants further investigation.