Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration

• Published in: Journal of neural transplantation & plasticity Vol. 2016; no. 2016; pp. 1 - 15
• Main Authors: Sotiropoulos, Ioannis, Almeida, Osborne F. X., Tronche, Francois, Silva, Joana Margarida, Rodrigues, Ana João, Vyas, Sheela, Sousa, Nuno
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc; Wiley
• Subjects: Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer's disease; Animals; Brain - metabolism; Corticosteroids; Development and progression; DNA methylation; Epigenetics; Genes; Genetic aspects; Genetic transcription; Glucocorticoids - metabolism; Humans; Inflammation - complications; Inflammation - metabolism; Kinases; Life Sciences; Nervous system diseases; Neurobiology; Neurodegeneration; Neuronal Plasticity; Neurons; Neurons and Cognition; Neurophysiology; Neuroplasticity; Parkinson Disease - etiology; Parkinson Disease - metabolism; Parkinson's disease; Physiological aspects; Review; Risk Factors; Steroids; Stress, Psychological - complications; Stress, Psychological - metabolism

Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central nervous system, ranging from the regulation of gene transcription, cellular signaling, modulation of synaptic structure, and transmission and glial function to behavior. Their actions are mediated by glucocorticoi...