PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

• Published in: Nature Vol. 450; no. 7166; pp. 106 - 109
• Main Authors: Batterham, Rachel L., ffytche, Dominic H., Rosenthal, J. Miranda, Zelaya, Fernando O., Barker, Gareth J., Withers, Dominic J., Williams, Steven C. R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2007; Nature Publishing; Nature Publishing Group
• Subjects: Appetite Regulation - drug effects; Appetite Regulation - physiology; Behavior; Biological and medical sciences; Body weight; Brain; Cerebral Cortex - anatomy & histology; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Cross-Over Studies; Feeding behavior; Feeding Behavior - drug effects; Feeding Behavior - physiology; Feeding. Feeding behavior; Food; Fundamental and applied biological sciences. Psychology; Homeostasis - drug effects; Humanities and Social Sciences; Humans; Hypothalamus - drug effects; Hypothalamus - physiology; letter; Male; Mammals; multidisciplinary; Neurons; Neurosciences; Nutrients; Obesity; Peptide YY - blood; Peptide YY - metabolism; Peptide YY - pharmacology; Peptides; Physiology; Satiation - drug effects; Satiation - physiology; Science; Science (multidisciplinary); Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Orbitofrontal cortex; Feeding behavior; Central nervous system; Satiety; Limbic system; Hypothalamus; Nuclear magnetic resonance imaging; YY peptide; Encephalon; Feeding; Functional imaging

Functional magnetic resonance imaging is used to examine brain areas whose activity correlates with subsequent feeding behaviour under different satiety states evoked by intravenous peptide YY 3–36 (PYY), administration. Under high PYY conditions, (mimicking the fed state) changes in orbitofrontal c...