Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila

• Published in: PLoS genetics Vol. 12; no. 3; p. e1005918
• Main Authors: Upadhyay, Maitreyi, Martino Cortez, Yesenia, Wong-Deyrup, SiuWah, Tavares, Leticia, Schowalter, Sean, Flora, Pooja, Hill, Corinne, Nasrallah, Mohamad Ali, Chittur, Sridar, Rangan, Prashanth
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.03.2016; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Cell differentiation; Cell Differentiation - genetics; Cell division; Chromatin - genetics; Cysts; DNA Transposable Elements - genetics; Drosophila; Drosophila melanogaster - genetics; Drosophila melanogaster - growth & development; Drosophila Proteins - biosynthesis; Drosophila Proteins - genetics; Gene expression; Gene Expression Regulation, Developmental; Genetic aspects; Genome, Insect; Germ Cells - growth & development; Germ Cells - metabolism; Glycoproteins - biosynthesis; Glycoproteins - genetics; Humans; Insects; Mice; Oogenesis - genetics; Physiological aspects; Research and Analysis Methods; Stem cells; Stem Cells - metabolism; Transposons; Wnt Proteins - biosynthesis; Wnt Proteins - genetics
• ISSN: 1553-7404; 1553-7390; 1553-7404
• DOI: 10.1371/journal.pgen.1005918

Germline stem cell (GSC) self-renewal and differentiation are required for the sustained production of gametes. GSC differentiation in Drosophila oogenesis requires expression of the histone methyltransferase dSETDB1 by the somatic niche, however its function in this process is unknown. Here, we sho...