The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium

• Published in: PLoS genetics Vol. 12; no. 8; p. e1006258
• Main Authors: Colgan, Aoife M., Kröger, Carsten, Diard, Médéric, Hardt, Wolf-Dietrich, Puente, José L., Sivasankaran, Sathesh K., Hokamp, Karsten, Hinton, Jay C. D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.08.2016; Public Library of Science (PLoS)
• Subjects: Bacterial Proteins - biosynthesis; Bacterial Proteins - genetics; Biology and Life Sciences; Datasets; Deoxyribonucleic acid; DNA; Experiments; Gene expression; Gene Expression Regulation, Bacterial; Genetic aspects; Genetic regulation; Genetic research; Genetic testing; Host Factor 1 Protein - biosynthesis; Host Factor 1 Protein - genetics; Infections; Mammals; Medicine and Health Sciences; Membrane Proteins - biosynthesis; Membrane Proteins - genetics; Mortality; Pathogens; Phylogenetics; RNA; RNA, Small Untranslated - genetics; Salmonella; Salmonella enterica; Salmonella typhimurium; Salmonella typhimurium - genetics; Salmonella typhimurium - growth & development; Salmonella typhimurium - pathogenicity; Serogroup; Sigma Factor - biosynthesis; Sigma Factor - genetics; Transcription factors; Transcriptome - genetics; Virulence

We know a great deal about the genes used by the model pathogen Salmonella enterica serovar Typhimurium to cause disease, but less about global gene regulation. New tools for studying transcripts at the single nucleotide level now offer an unparalleled opportunity to understand the bacterial transcr...