Inbreeding depression across the genome of Dutch Holstein Friesian dairy cattle

• Published in: Genetics Selection Evolution Vol. 52; no. 1; p. 64
• Main Authors: Doekes, Harmen P., Bijma, Piter, Veerkamp, Roel F., de Jong, Gerben, Wientjes, Yvonne C.J., Windig, Jack J.
• Format: Journal Article
• Language: English
• Published: France Springer Science and Business Media LLC 28.10.2020; BioMed Central Ltd; BioMed Central; BMC
• Subjects: [SDV]Life Sciences [q-bio]; accounting; additive effect; Analysis; Animal culture; Animals; Cattle; Cattle - genetics; Cattle - physiology; Chromosome 5; Chromosomes; cows; Dairy cattle; Dominance; evolution; Fertility; Gene frequency; Gene loci; Genes, Dominant; Genetic Load; Genetic research; Genetics; genome; Genomes; Genomics; Genotypes; Holstein; Homozygosity; Homozygote; Inbreeding; Inbreeding Depression; Life Science; Life Sciences; loci; methodology; Milk; Milk - standards; Milk production; milk yield; Pedigree; Phenotype; Phenotypes; phenotypic variation; Phenotypic variations; Polymorphism, Single Nucleotide; QH426-470; Research Article; SF1-1100; Udder; udders; variance

Inbreeding depression refers to the decrease in mean performance due to inbreeding. Inbreeding depression is caused by an increase in homozygosity and reduced expression of (on average) favourable dominance effects. Dominance effects and allele frequencies differ across loci, and consequently inbree...