Loss of photoreceptors results in upregulation of synaptic proteins in bipolar cells and amacrine cells

• Published in: PloS one Vol. 9; no. 3; p. e90250
• Main Authors: Dagar, Sushma, Nagar, Saumya, Goel, Manvi, Cherukuri, Pitchaiah, Dhingra, Narender K
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.03.2014; Public Library of Science (PLoS)
• Subjects: Aberration; Amacrine cells; Amacrine Cells - cytology; Amacrine Cells - metabolism; Animal models; Animals; Biology; Bipolar cells; Brain; Central nervous system; Circuits; Degeneration; Down-Regulation - genetics; Eye Proteins - genetics; Eye Proteins - metabolism; Firing pattern; Horizontal cells; Medicine; Mice, Inbred C57BL; mRNA; Neurodegeneration; Photoreception; Photoreceptor Cells, Vertebrate - metabolism; Photoreceptors; Proteins; Qa-SNARE Proteins - genetics; Qa-SNARE Proteins - metabolism; Retina; Retinal Bipolar Cells - cytology; Retinal Bipolar Cells - metabolism; Retinal degeneration; Retinal ganglion cells; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Synapses - metabolism; Synapsin; Synapsin I; Synaptophysin; Synaptophysin - genetics; Synaptophysin - metabolism; Syntaxin; Up-regulation; Up-Regulation - genetics

Deafferentation is known to cause significant changes in the postsynaptic neurons in the central nervous system. Loss of photoreceptors, for instance, results in remarkable morphological and physiological changes in bipolar cells and horizontal cells. Retinal ganglion cells (RGCs), which send visual...