Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system

• Published in: PloS one Vol. 9; no. 5; p. e96092
• Main Authors: Timsit, Yoav E, Negishi, Masahiko
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.05.2014; Public Library of Science (PLoS)
• Subjects: Animals; Benzene; Bile acids; Bilirubin; Biology and Life Sciences; CAR protein; CYP2B6 gene; Cytochrome; Cytoplasm; Cytoplasm - drug effects; Cytoplasm - metabolism; Deoxyribonucleic acid; DNA; Dose-Response Relationship, Drug; Drugs; Environmental health; Fatty acids; Gene regulation; Genes; Health sciences; Heat shock; Heat shock proteins; Heat-Shock Response - drug effects; Hep G2 Cells; Hsp60 protein; HSP70 Heat-Shock Proteins - metabolism; Hsp70 protein; Hsp90 protein; Humans; Immunoprecipitation; Laboratories; Leupeptins - pharmacology; Ligands; Liver cancer; Medicine and Health Sciences; Metabolic pathways; Mice; Nuclei; Penicillin; Phenobarbital; Phenobarbital - pharmacology; Phosphatase; Physiology; Plasmids; Proteasome Endopeptidase Complex - metabolism; Proteasome Inhibitors - pharmacology; Proteasomes; Protein interaction; Protein-protein interactions; Pyridines - pharmacology; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Regulation; Toxicology; Transcription activation; Transcriptional Activation - drug effects; Ubiquitin; Ubiquitin - metabolism; Ubiquitination; Ubiquitination - drug effects; North Carolina; United States > US

The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic pathways for chemicals such as drugs, glucose, fatty acids, bilirubin, and bile acids. Currently, it is known that in its inactive state, CAR...