Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways

• Published in: PloS one Vol. 10; no. 10; p. e0139914
• Main Authors: Brobey, Reynolds K, German, Dwight, Sonsalla, Patricia K, Gurnani, Prem, Pastor, Johanne, Hsieh, C-C, Papaconstantinou, John, Foster, Philip P, Kuro-o, Makoto, Rosenblatt, Kevin P
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.10.2015; Public Library of Science (PLoS)
• Subjects: Activation; Animals; Apoptosis; Biochemistry; Brain; Brain - metabolism; Brain - pathology; Cancer; Cardiovascular disease; Degeneration; Deoxyguanosine; Dopamine; Dopamine receptors; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Enzyme Activation; Fibroblasts; Genetic aspects; Glucuronidase - genetics; Glucuronidase - metabolism; Growth factors; Internal medicine; Kinases; Klotho protein; Klotho Proteins; Life assessment; MAP kinase; MAP Kinase Kinase Kinase 5 - genetics; MAP Kinase Kinase Kinase 5 - metabolism; MAP Kinase Signaling System; Medical schools; Medicine; Metabolism; Mice; Mice, Knockout; Mitochondrial DNA; Molecular biology; MPTP; Neurodegeneration; Neurons; Oxidation resistance; Oxidation-Reduction; Oxidative Stress; Oxygen; p38 Mitogen-Activated Protein Kinases - genetics; p38 Mitogen-Activated Protein Kinases - metabolism; Physiological aspects; Protein kinases; Proteomics; Reactive oxygen species; Rodents; Substantia nigra; Thioredoxin; Transgenic animals; Transgenic mice; Japan; United States > US; Texas

Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant defense mechanism has not been locally investigated in the brain. Here, we tested the hypothesis that the reactive oxygen species (ROS)-sensitive a...