Immunodominance of Antigenic Site B over Site A of Hemagglutinin of Recent H3N2 Influenza Viruses

• Published in: PloS one Vol. 7; no. 7; p. e41895
• Main Authors: Popova, Lyubov, Smith, Kenneth, West, Ann H., Wilson, Patrick C., James, Judith A., Thompson, Linda F., Air, Gillian M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.07.2012; Public Library of Science (PLoS)
• Subjects: Amino acids; Analysis; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antigenic drift; Antigens; Antigens, Viral - genetics; Antigens, Viral - immunology; B cells; Biology; Dominance; Enzyme-linked immunosorbent assay; Epidemics; Epitopes - genetics; Epitopes - immunology; Exo-a-sialidase; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; Human populations; Humans; Immunization; Immunodominance; Influenza; Influenza A; Influenza A Virus, H3N2 Subtype - genetics; Influenza A Virus, H3N2 Subtype - immunology; Influenza vaccines; Influenza viruses; Lectins; Medicine; Models, Molecular; Monoclonal antibodies; Mutants; Mutation; Pandemics; Plasmas; Plasmas (physics); Protein Conformation; Seasons; Species Specificity; Vaccination; Vaccines; Viruses; United States > US; Oklahoma

H3N2 influenza viruses have now circulated in the human population for 43 years since the pandemic of 1968, accumulating sequence changes in the hemagglutinin (HA) and neuraminidase (NA) that are believed to be predominantly due to selection for escape from antibodies. Examination of mutations that...