Assessment of TP53 mutations in benign and malignant salivary gland neoplasms

• Published in: PloS one Vol. 7; no. 7; p. e41261
• Main Authors: Gomes, Carolina Cavaliéri, Diniz, Marina Gonçalves, Orsine, Lissur Azevedo, Duarte, Alessandra Pires, Fonseca-Silva, Thiago, Conn, Brendan I, De Marco, Luiz, Pereira, Cláudia Maria, Gomez, Ricardo Santiago
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.07.2012; Public Library of Science (PLoS)
• Subjects: Adenocarcinoma; Adenoid; Adenoma; Adenoma, Pleomorphic - genetics; Adolescent; Adult; Aged; Analysis; Apoptosis; Benign; Biology; Biomarkers; Breast cancer; Cancer therapies; Cell survival; Chemotherapy; Codon, Nonsense - genetics; Dentistry; Deoxyribonucleic acid; Development and progression; DNA; Exons; Exons - genetics; Female; Genetic aspects; Genetic markers; Heat shock proteins; Heterozygosity; Humans; Immunohistochemistry; Introns - genetics; Loss of heterozygosity; Loss of Heterozygosity - genetics; Male; Medicine; Microsatellites; Middle Aged; Missense mutation; Mutation; Mutation, Missense - genetics; Neoplasia; Neoplasms; Nonsense mutation; Oral cancer; p53 Protein; Pathogenesis; Pathology; Patients; Polymerase Chain Reaction; Prostate; Reverse transcription; Salivary gland; Salivary Gland Neoplasms - genetics; Single-nucleotide polymorphism; Surgery; Thyroid gland; Tumor proteins; Tumor Suppressor Protein p53 - genetics; Tumors; Young Adult; Brazil; Scotland; Edinburgh Scotland; United Kingdom > UK

Despite advances in the understanding of the pathogenesis of salivary gland neoplasms (SGN), the molecular pathways associated with enhanced tumor growth and cell survival remain to be established. The aim of the present study was to investigate whether TP53 mutations are relevant to SGN pathogenesi...