Focused Ultrasound-Induced Blood–Brain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study - Wei, Kuo-Chen; Chu, Po-Chun; Wang, Hay-Yan Jack; Huang, Chiung-Yin; Chen, Pin-Yuan; Tsai, Hong-Chieh; Lu, Yu-Jen; Lee, Pei-Yun; Tseng, I-Chou; Feng, Li-Ying; Hsu, Peng-Wei; Yen, Tzu-Chen; et al. (PloS one, 2013)
Keywords: Animal tissues; Animals; Antineoplastic Agents, Alkylating - pharmacokinetics; Antineoplastic Agents, Alkylating - therapeutic use; Biology; Blood-brain barrier; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - radiation effects; Brain; Brain - pathology; Brain cancer; Brain Neoplasms - diagnosis; Brain Neoplasms - drug therapy; Brain Neoplasms - mortality; Brain research; Brain tumors; Cancer therapies; Cell Line, Tumor; Cerebrospinal fluid; Chemotherapy; Clinical trials; Dacarbazine - analogs & derivatives; Dacarbazine - pharmacokinetics; Dacarbazine - therapeutic use; Development and progression; Disease Models, Animal; Drug Evaluation, Preclinical; Dyes; Electrical engineering; Engineering; Glioblastoma; Glioblastoma - diagnosis; Glioblastoma - drug therapy; Glioblastoma - mortality; Glioblastoma multiforme; Glioblastomas; Glioma cells; Health aspects; Histology; Magnetic resonance; Magnetic Resonance Imaging; Male; Medical imaging; Medicine; Molecular weight; Neuroimaging; Neurosurgery; NMR; Nuclear magnetic resonance; Parenchyma; Permeability; Rats; Sound; Spectrophotometry; Survival; Temozolomide; Tumors; Ultrasonic imaging; Ultrasound; United States--US; Taiwan