Mesenchymal stromal cells from human umbilical cord prevent the development of lung fibrosis in immunocompetent mice

Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we investigated the...

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Published in	PloS one Vol. 13; no. 6; p. e0196048
Main Authors	Moroncini, Gianluca, Paolini, Chiara, Orlando, Fiorenza, Capelli, Chiara, Grieco, Antonella, Tonnini, Cecilia, Agarbati, Silvia, Mondini, Eleonora, Saccomanno, Stefania, Goteri, Gaia, Svegliati Baroni, Silvia, Provinciali, Mauro, Introna, Martino, Del Papa, Nicoletta, Gabrielli, Armando
Format	Journal Article
Language	English
Published	United States Public Library of Science 01.06.2018 Public Library of Science (PLoS)
Subjects	Aging Biology and Life Sciences Bleomycin Bone marrow Cesarean section Clinical trials Collagen Connective tissue diseases Connective tissues Etiology Fibrosis Health aspects Immunocompetence In vivo methods and tests Inflammation Injury prevention Interleukin 1 Interleukin 10 Interleukin 6 Lung diseases Lungs Macrophages Medical research Medicine and Health Sciences Mesenchymal stem cells Mesenchyme Mice Prevention Pulmonary fibrosis Rats Research and Analysis Methods Stem cells Stromal cells Therapy Transplants & implants Umbilical cord Italy
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Abstract	Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we investigated the anti-fibrotic activity in vivo of human mesenchymal stromal cells obtained from whole umbilical cord (hUC-MSC). Adult immunocompetent C57BL/6 mice (n. = 8 for each experimental condition) were injected intravenously with hUC-MSC (n. = 2.5 × 105) twice, 24 hours and 7 days after endotracheal injection of bleomycin. Upon sacrifice at days 8, 14, 21, collagen content, inflammatory cytokine profile, and hUC-MSC presence in explanted lung tissue were analyzed. Systemic administration of a double dose of hUC-MSC significantly reduced bleomycin-induced lung injury (inflammation and fibrosis) in mice through a selective inhibition of the IL6-IL10-TGFβ axis involving lung M2 macrophages. Only few hUC-MSC were detected from explanted lungs, suggesting a "hit and run" mechanism of action of this cellular therapy. Our data indicate that hUC-MSC possess strong in vivo anti-fibrotic activity in a mouse model resembling an immunocompetent human subject affected by inflammatory ILD, providing proof of concept for ad-hoc clinical trials.
AbstractList	Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we investigated the anti-fibrotic activity in vivo of human mesenchymal stromal cells obtained from whole umbilical cord (hUC-MSC). Adult immunocompetent C57BL/6 mice (n. = 8 for each experimental condition) were injected intravenously with hUC-MSC (n. = 2.5 × 105) twice, 24 hours and 7 days after endotracheal injection of bleomycin. Upon sacrifice at days 8, 14, 21, collagen content, inflammatory cytokine profile, and hUC-MSC presence in explanted lung tissue were analyzed. Systemic administration of a double dose of hUC-MSC significantly reduced bleomycin-induced lung injury (inflammation and fibrosis) in mice through a selective inhibition of the IL6-IL10-TGFβ axis involving lung M2 macrophages. Only few hUC-MSC were detected from explanted lungs, suggesting a "hit and run" mechanism of action of this cellular therapy. Our data indicate that hUC-MSC possess strong in vivo anti-fibrotic activity in a mouse model resembling an immunocompetent human subject affected by inflammatory ILD, providing proof of concept for ad-hoc clinical trials. Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we investigated the anti-fibrotic activity in vivo of human mesenchymal stromal cells obtained from whole umbilical cord (hUC-MSC). Adult immunocompetent C57BL/6 mice (n. = 8 for each experimental condition) were injected intravenously with hUC-MSC (n. = 2.5 × 10 5 ) twice, 24 hours and 7 days after endotracheal injection of bleomycin. Upon sacrifice at days 8, 14, 21, collagen content, inflammatory cytokine profile, and hUC-MSC presence in explanted lung tissue were analyzed. Systemic administration of a double dose of hUC-MSC significantly reduced bleomycin-induced lung injury (inflammation and fibrosis) in mice through a selective inhibition of the IL6-IL10-TGFβ axis involving lung M2 macrophages. Only few hUC-MSC were detected from explanted lungs, suggesting a “hit and run” mechanism of action of this cellular therapy. Our data indicate that hUC-MSC possess strong in vivo anti-fibrotic activity in a mouse model resembling an immunocompetent human subject affected by inflammatory ILD, providing proof of concept for ad-hoc clinical trials. Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we investigated the anti-fibrotic activity in vivo of human mesenchymal stromal cells obtained from whole umbilical cord (hUC-MSC). Adult immunocompetent C57BL/6 mice (n. = 8 for each experimental condition) were injected intravenously with hUC-MSC (n. = 2.5 x 10.sup.5) twice, 24 hours and 7 days after endotracheal injection of bleomycin. Upon sacrifice at days 8, 14, 21, collagen content, inflammatory cytokine profile, and hUC-MSC presence in explanted lung tissue were analyzed. Systemic administration of a double dose of hUC-MSC significantly reduced bleomycin-induced lung injury (inflammation and fibrosis) in mice through a selective inhibition of the IL6-IL10-TGF[beta] axis involving lung M2 macrophages. Only few hUC-MSC were detected from explanted lungs, suggesting a "hit and run" mechanism of action of this cellular therapy. Our data indicate that hUC-MSC possess strong in vivo anti-fibrotic activity in a mouse model resembling an immunocompetent human subject affected by inflammatory ILD, providing proof of concept for ad-hoc clinical trials. Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we investigated the anti-fibrotic activity in vivo of human mesenchymal stromal cells obtained from whole umbilical cord (hUC-MSC). Adult immunocompetent C57BL/6 mice (n. = 8 for each experimental condition) were injected intravenously with hUC-MSC (n. = 2.5 × 105) twice, 24 hours and 7 days after endotracheal injection of bleomycin. Upon sacrifice at days 8, 14, 21, collagen content, inflammatory cytokine profile, and hUC-MSC presence in explanted lung tissue were analyzed. Systemic administration of a double dose of hUC-MSC significantly reduced bleomycin-induced lung injury (inflammation and fibrosis) in mice through a selective inhibition of the IL6-IL10-TGFβ axis involving lung M2 macrophages. Only few hUC-MSC were detected from explanted lungs, suggesting a "hit and run" mechanism of action of this cellular therapy. Our data indicate that hUC-MSC possess strong in vivo anti-fibrotic activity in a mouse model resembling an immunocompetent human subject affected by inflammatory ILD, providing proof of concept for ad-hoc clinical trials.Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we investigated the anti-fibrotic activity in vivo of human mesenchymal stromal cells obtained from whole umbilical cord (hUC-MSC). Adult immunocompetent C57BL/6 mice (n. = 8 for each experimental condition) were injected intravenously with hUC-MSC (n. = 2.5 × 105) twice, 24 hours and 7 days after endotracheal injection of bleomycin. Upon sacrifice at days 8, 14, 21, collagen content, inflammatory cytokine profile, and hUC-MSC presence in explanted lung tissue were analyzed. Systemic administration of a double dose of hUC-MSC significantly reduced bleomycin-induced lung injury (inflammation and fibrosis) in mice through a selective inhibition of the IL6-IL10-TGFβ axis involving lung M2 macrophages. Only few hUC-MSC were detected from explanted lungs, suggesting a "hit and run" mechanism of action of this cellular therapy. Our data indicate that hUC-MSC possess strong in vivo anti-fibrotic activity in a mouse model resembling an immunocompetent human subject affected by inflammatory ILD, providing proof of concept for ad-hoc clinical trials.
Audience	Academic
Author	Grieco, Antonella Introna, Martino Orlando, Fiorenza Provinciali, Mauro Svegliati Baroni, Silvia Mondini, Eleonora Del Papa, Nicoletta Paolini, Chiara Capelli, Chiara Goteri, Gaia Gabrielli, Armando Agarbati, Silvia Saccomanno, Stefania Moroncini, Gianluca Tonnini, Cecilia
AuthorAffiliation	3 UOS Centro di Terapia Cellulare "G. Lanzani", A.S.S.T. Papa Giovanni XXIII, Bergamo, Italy 5 AnatomiaPatologica, Dipartimento di Scienze Biomediche s e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy 1 Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy 6 UOC Day Hospital di Reumatologia, Dipartimento di Reumatologia, ASST G. Pini-CTO, Milano, Italy Centre National de la Recherche Scientifique, FRANCE 4 Dipartimento di Medicina Sperimentale e Clinica, Università Politecnica delle Marche, Ancona, Italy 2 Centro di Tecnologie Avanzate nell’Invecchiamento, IRCCS-INRCA, Ancona, Italy
AuthorAffiliation_xml	– name: 3 UOS Centro di Terapia Cellulare "G. Lanzani", A.S.S.T. Papa Giovanni XXIII, Bergamo, Italy – name: 5 AnatomiaPatologica, Dipartimento di Scienze Biomediche s e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy – name: 6 UOC Day Hospital di Reumatologia, Dipartimento di Reumatologia, ASST G. Pini-CTO, Milano, Italy – name: 4 Dipartimento di Medicina Sperimentale e Clinica, Università Politecnica delle Marche, Ancona, Italy – name: 1 Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy – name: 2 Centro di Tecnologie Avanzate nell’Invecchiamento, IRCCS-INRCA, Ancona, Italy – name: Centre National de la Recherche Scientifique, FRANCE
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Cites_doi	10.1016/j.bbrc.2007.01.045 10.1002/stem.1271 10.1016/j.brainres.2007.05.010 10.1002/art.39125 10.1038/s41598-017-13511-z 10.1186/s13075-015-0819-7 10.4236/abb.2014.51004 10.5966/sctm.2015-0379 10.1016/j.imlet.2015.05.017 10.1084/jem.20162152 10.1016/j.immuni.2014.06.008 10.1001/jama.2014.6368 10.1016/j.tem.2016.09.005 10.1186/ar4606 10.1007/s00441-017-2699-4 10.1073/pnas.1416121111 10.1007/s10616-014-9718-z 10.2353/ajpath.2009.080629 10.1073/pnas.1432929100 10.3892/ijmm.2013.1572 10.3389/fimmu.2012.00297 10.3389/fimmu.2015.00648 10.1002/art.39477 10.1189/jlb.1012512 10.1038/nrrheum.2013.166 10.1172/JCI59643 10.1164/rccm.201106-0965OC 10.1016/j.scr.2015.04.003 10.1016/j.matbio.2016.01.010 10.3727/096368915X688182 10.15283/ijsc16041 10.1136/annrheumdis-2016-209909 10.1016/j.jcyt.2015.11.013 10.1016/j.jtos.2015.11.004 10.4049/jimmunol.180.4.2650 10.3109/14653249.2011.563294 10.1111/j.1348-0421.1992.tb02045.x 10.1002/art.22204 10.1164/rccm.200702-326OC 10.1186/scrt216 10.1183/09059180.00003214 10.1016/j.autrev.2015.02.002 10.1016/j.transproceed.2008.01.080 10.3892/etm.2017.4222 10.1097/01.mcp.0000410742.90463.1f 10.1155/2015/816460 10.1136/jcp.41.4.467 10.1111/j.1365-2567.2008.02891.x 10.3389/fimmu.2015.00602 10.1056/NEJMoa055120 10.1182/blood-2010-12-327353
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References	M Wang (ref17) 2009; 126 DJ Prockop (ref5) 2016; 51 N Cimolai (ref23) 1992; 36 C Capelli (ref19) 2011; 13 RH Lee (ref21) 2014; 111 VJ Coulson-Thomas (ref2) 2016; 14 JM van Laar (ref11) 2014; 311 AC MacKinnon (ref30) 2008; 180 R Montironi (ref22) 2008; 30 SF de Witte (ref48) 2016; 6 Y Moodley (ref18) 2009; 175 RK Hoyles (ref9) 2006; 54 A Cras (ref6) 2015; 17 M Iudici (ref13) 2015; 14 P Fraticelli (ref12) 2014; 16 C Franceschi (ref52) 2017; 28 M Sanchez-Alavez (ref20) 2007; 1158 SE New (ref34) 2015; 15 M Provinciali (ref54) 2011; 17 F Zhao (ref50) 2008; 40 H Wang (ref16) 2014; 33 AV Misharin (ref43) 2017; 214 P Luz-Crawford (ref49) 2013; 4 E Eggenhofer (ref38) 2012; 3 TT Braga (ref41) 2015; 6 CR Kliment (ref26) 2011; 4 EA Ayaub (ref33) 2017; 7 Y Iso (ref47) 2007; 354 M Najar (ref1) 2016; 18 A Tyndall (ref4) 2015; 168 T Roszer (ref31) 2015; 2015 AC Mackinnon (ref32) 2012; 185 A Sica (ref27) 2012; 122 M Reddy (ref45) 2016; 9 D Bharti (ref36) 2018; 372 C Zhang (ref51) 2017; 13 T Ashcroft (ref24) 1988; 41 O Kowal-Bielecka (ref14) 2017; 76 AT Maria (ref40) 2016; 68 H Choi (ref46) 2011; 118 DC Ding (ref15) 2015; 25 LA Ortiz (ref44) 2003; 100 DP Tashkin (ref10) 2007; 176 PJ Murray (ref28) 2014; 41 A Tyndall (ref3) 2014; 10 G Moroncini (ref25) 2015; 67 AU Wells (ref7) 2009; 48 DP Tashkin (ref8) 2006; 354 R Secunda (ref35) 2015; 67 G Bagnato (ref42) 2015; 24 EG Schmuck (ref39) 2016; 5 V Sueblinvong (ref53) 2014; 5 J Nystedt (ref37) 2013; 31 ML Novak (ref29) 2013; 93 26142543 - Immunol Lett. 2015 Dec;168(2):201-7 21577320 - Int J Clin Exp Pathol. 2011 Apr;4(4):349-55 17133610 - Arthritis Rheum. 2006 Dec;54(12):3962-70 17717203 - Am J Respir Crit Care Med. 2007 Nov 15;176(10):1026-34 21551236 - Blood. 2011 Jul 14;118(2):330-8 23734780 - Stem Cell Res Ther. 2013 Jun 04;4(3):65 26089604 - Mediators Inflamm. 2015;2015:816460 17570349 - Brain Res. 2007 Jul 16;1158:71-80 27941129 - Ann Rheum Dis. 2017 Aug;76(8):1327-1339 23056000 - Front Immunol. 2012 Sep 26;3:297 17257581 - Biochem Biophys Res Commun. 2007 Mar 16;354(3):700-6 18624725 - Immunology. 2009 Feb;126(2):220-32 19497992 - Am J Pathol. 2009 Jul;175(1):303-13 26525582 - Arthritis Res Ther. 2015 Nov 03;17:301 12815096 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8407-11 29038604 - Sci Rep. 2017 Oct 16;7(1):13281 23505314 - J Leukoc Biol. 2013 Jun;93(6):875-81 28694385 - J Exp Med. 2017 Aug 7;214(8):2387-2404 25058083 - JAMA. 2014 Jun 25;311(24):2490-8 26779185 - Front Immunol. 2016 Jan 06;6:648 25808833 - Arthritis Rheumatol. 2015 Jul;67(7):1891-903 21417678 - Cytotherapy. 2011 Aug;13(7):786-801 3366935 - J Clin Pathol. 1988 Apr;41(4):467-70 28565787 - Exp Ther Med. 2017 May;13(5):1922-1926 26857227 - Cytotherapy. 2016 Mar;18(3):320-35 24217581 - Nat Rev Rheumatol. 2014 Feb;10 (2):117-24 23132820 - Stem Cells. 2013 Feb;31(2):317-26 27789101 - Trends Endocrinol Metab. 2017 Mar;28(3):199-212 18936524 - Cell Oncol. 2008;30(6):473-82 26804815 - Ocul Surf. 2016 Apr;14 (2):121-34 29204746 - Cell Tissue Res. 2018 Apr;372(1):51-65 25709096 - Autoimmun Rev. 2015 Jul;14(7):575-8 27460855 - Stem Cells Transl Med. 2016 Dec;5(12 ):1668-1675 22095546 - Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46 26807758 - Matrix Biol. 2016 Apr;51:7-13 26474311 - Arthritis Rheumatol. 2016 Apr;68(4):1013-25 25726561 - Eur Respir Rev. 2015 Mar;24(135):102-14 19487223 - Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii40-4 22378047 - J Clin Invest. 2012 Mar;122(3):787-95 25385603 - Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16766-71 24297321 - Int J Mol Med. 2014 Feb;33(2):263-70 1513263 - Microbiol Immunol. 1992;36(5):465-78 18250477 - J Immunol. 2008 Feb 15;180(4):2650-8 24596659 - Adv Biosci Biotechnol. 2014 Jan;5(1):19-30 26044082 - Cell Transplant. 2016;25(2):217-28 26635814 - Front Immunol. 2015 Nov 25;6:602 25035950 - Immunity. 2014 Jul 17;41(1):14-20 24798808 - Cytotechnology. 2015 Oct;67(5):793-807 25007944 - Arthritis Res Ther. 2014 Jul 08;16(4):R144 16790698 - N Engl J Med. 2006 Jun 22;354(25):2655-66 22209928 - Curr Opin Pulm Med. 2011 Dec;17 Suppl 1:S3-10 27871152 - Int J Stem Cells. 2016 Nov 30;9(2):192-206 25957945 - Stem Cell Res. 2015 Jul;15(1):1-13 18589176 - Transplant Proc. 2008 Jun;40(5):1700-5
References_xml	– volume: 354 start-page: 700 issue: 3 year: 2007 ident: ref47 article-title: Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2007.01.045 – volume: 31 start-page: 317 issue: 2 year: 2013 ident: ref37 article-title: Cell surface structures influence lung clearance rate of systemically infused mesenchymal stromal cells publication-title: Stem Cells doi: 10.1002/stem.1271 – volume: 1158 start-page: 71 year: 2007 ident: ref20 article-title: Contributions of neuronal prion protein on sleep recovery and stress response following sleep deprivation publication-title: Brain Res doi: 10.1016/j.brainres.2007.05.010 – volume: 67 start-page: 1891 issue: 7 year: 2015 ident: ref25 article-title: Epitope Specificity Determines Pathogenicity and Detectability of Anti-Platelet-Derived Growth Factor Receptor alpha Autoantibodies in Systemic Sclerosis publication-title: Arthritis Rheumatol doi: 10.1002/art.39125 – volume: 7 start-page: 13281 issue: 1 year: 2017 ident: ref33 article-title: Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis publication-title: Sci Rep doi: 10.1038/s41598-017-13511-z – volume: 17 start-page: 301 year: 2015 ident: ref6 article-title: Update on mesenchymal stem cell-based therapy in lupus and scleroderma publication-title: Arthritis Res Ther doi: 10.1186/s13075-015-0819-7 – volume: 5 start-page: 19 issue: 1 year: 2014 ident: ref53 article-title: Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury publication-title: Adv Biosci Biotechnol doi: 10.4236/abb.2014.51004 – volume: 5 start-page: 1668 issue: 12 year: 2016 ident: ref39 article-title: Biodistribution and Clearance of Human Mesenchymal Stem Cells by Quantitative Three-Dimensional Cryo-Imaging After Intravenous Infusion in a Rat Lung Injury Model publication-title: Stem Cells Transl Med doi: 10.5966/sctm.2015-0379 – volume: 168 start-page: 201 issue: 2 year: 2015 ident: ref4 article-title: Mesenchymal stromal cells and rheumatic disorders publication-title: Immunol Lett doi: 10.1016/j.imlet.2015.05.017 – volume: 214 start-page: 2387 issue: 8 year: 2017 ident: ref43 article-title: Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span publication-title: J Exp Med doi: 10.1084/jem.20162152 – volume: 41 start-page: 14 issue: 1 year: 2014 ident: ref28 article-title: Macrophage activation and polarization: nomenclature and experimental guidelines publication-title: Immunity doi: 10.1016/j.immuni.2014.06.008 – volume: 311 start-page: 2490 issue: 24 year: 2014 ident: ref11 article-title: Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial publication-title: Jama doi: 10.1001/jama.2014.6368 – volume: 28 start-page: 199 issue: 3 year: 2017 ident: ref52 article-title: Inflammaging and ‘Garb-aging’ publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2016.09.005 – volume: 16 start-page: R144 issue: 4 year: 2014 ident: ref12 article-title: Low-dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study publication-title: Arthritis Res Ther doi: 10.1186/ar4606 – volume: 4 start-page: 349 issue: 4 year: 2011 ident: ref26 article-title: A novel method for accurate collagen and biochemical assessment of pulmonary tissue utilizing one animal publication-title: Int J Clin Exp Pathol – volume: 372 start-page: 51 issue: 1 year: 2018 ident: ref36 article-title: Comparative analysis of human Wharton’s jelly mesenchymal stem cells derived from different parts of the same umbilical cord publication-title: Cell Tissue Res doi: 10.1007/s00441-017-2699-4 – volume: 111 start-page: 16766 issue: 47 year: 2014 ident: ref21 article-title: TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1416121111 – volume: 67 start-page: 793 issue: 5 year: 2015 ident: ref35 article-title: Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study publication-title: Cytotechnology doi: 10.1007/s10616-014-9718-z – volume: 175 start-page: 303 issue: 1 year: 2009 ident: ref18 article-title: Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury publication-title: Am J Pathol doi: 10.2353/ajpath.2009.080629 – volume: 100 start-page: 8407 issue: 14 year: 2003 ident: ref44 article-title: Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1432929100 – volume: 33 start-page: 263 issue: 2 year: 2014 ident: ref16 article-title: Immunological characteristics of human umbilical cord mesenchymal stem cells and the therapeutic effects of their transplantion on hyperglycemia in diabetic rats publication-title: Int J Mol Med doi: 10.3892/ijmm.2013.1572 – volume: 3 start-page: 297 year: 2012 ident: ref38 article-title: Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion publication-title: Front Immunol doi: 10.3389/fimmu.2012.00297 – volume: 6 start-page: 648 year: 2016 ident: ref48 article-title: Toward Development of iMesenchymal Stem Cells for Immunomodulatory Therapy publication-title: Front Immunol doi: 10.3389/fimmu.2015.00648 – volume: 68 start-page: 1013 issue: 4 year: 2016 ident: ref40 article-title: Anti-fibrotic, anti-oxidant and immunomodulatory effects of mesenchymal stem cells in HOCl-induced systemic sclerosis publication-title: Arthritis Rheumatol doi: 10.1002/art.39477 – volume: 93 start-page: 875 issue: 6 year: 2013 ident: ref29 article-title: Macrophage phenotypes during tissue repair publication-title: J Leukoc Biol doi: 10.1189/jlb.1012512 – volume: 10 start-page: 117 issue: 2 year: 2014 ident: ref3 article-title: Mesenchymal stem cell treatments in rheumatology: a glass half full? publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2013.166 – volume: 122 start-page: 787 issue: 3 year: 2012 ident: ref27 article-title: Macrophage plasticity and polarization: in vivo veritas publication-title: J Clin Invest doi: 10.1172/JCI59643 – volume: 48 start-page: iii40 issue: Suppl 3 year: 2009 ident: ref7 article-title: Pulmonary complications: one of the most challenging complications of systemic sclerosis publication-title: Rheumatology (Oxford) – volume: 185 start-page: 537 issue: 5 year: 2012 ident: ref32 article-title: Regulation of transforming growth factor-beta1-driven lung fibrosis by galectin-3 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201106-0965OC – volume: 15 start-page: 1 issue: 1 year: 2015 ident: ref34 article-title: A matter of identity—Phenotype and differentiation potential of human somatic stem cells publication-title: Stem Cell Res doi: 10.1016/j.scr.2015.04.003 – volume: 51 start-page: 7 year: 2016 ident: ref5 article-title: Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells publication-title: Matrix Biol doi: 10.1016/j.matbio.2016.01.010 – volume: 25 start-page: 217 issue: 2 year: 2015 ident: ref15 article-title: Characterization of HLA-G and Related Immunosuppressive Effects in Human Umbilical Cord Stroma-Derived Stem Cells publication-title: Cell Transplant doi: 10.3727/096368915X688182 – volume: 9 start-page: 192 issue: 2 year: 2016 ident: ref45 article-title: Human Adipose-derived Mesenchymal Stem Cells Attenuate Early Stage of Bleomycin Induced Pulmonary Fibrosis: Comparison with Pirfenidone publication-title: Int J Stem Cells doi: 10.15283/ijsc16041 – volume: 76 start-page: 1327 issue: 8 year: 2017 ident: ref14 article-title: Update of EULAR recommendations for the treatment of systemic sclerosis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-209909 – volume: 18 start-page: 320 issue: 3 year: 2016 ident: ref1 article-title: Mesenchymal stromal cells from the foreskin: Tissue isolation, cell characterization and immunobiological properties publication-title: Cytotherapy doi: 10.1016/j.jcyt.2015.11.013 – volume: 14 start-page: 121 issue: 2 year: 2016 ident: ref2 article-title: Extrinsic and Intrinsic Mechanisms by Which Mesenchymal Stem Cells Suppress the Immune System publication-title: Ocul Surf doi: 10.1016/j.jtos.2015.11.004 – volume: 180 start-page: 2650 issue: 4 year: 2008 ident: ref30 article-title: Regulation of alternative macrophage activation by galectin-3 publication-title: J Immunol doi: 10.4049/jimmunol.180.4.2650 – volume: 13 start-page: 786 issue: 7 year: 2011 ident: ref19 article-title: Minimally manipulated whole human umbilical cord is a rich source of clinical-grade human mesenchymal stromal cells expanded in human platelet lysate publication-title: Cytotherapy doi: 10.3109/14653249.2011.563294 – volume: 36 start-page: 465 issue: 5 year: 1992 ident: ref23 article-title: Definition and application of a histopathological scoring scheme for an animal model of acute Mycoplasma pneumoniae pulmonary infection publication-title: Microbiol Immunol doi: 10.1111/j.1348-0421.1992.tb02045.x – volume: 54 start-page: 3962 issue: 12 year: 2006 ident: ref9 article-title: A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma publication-title: Arthritis Rheum doi: 10.1002/art.22204 – volume: 176 start-page: 1026 issue: 10 year: 2007 ident: ref10 article-title: Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200702-326OC – volume: 4 start-page: 65 issue: 3 year: 2013 ident: ref49 article-title: Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells publication-title: Stem Cell Res Ther doi: 10.1186/scrt216 – volume: 24 start-page: 102 issue: 135 year: 2015 ident: ref42 article-title: Cellular interactions in the pathogenesis of interstitial lung diseases publication-title: Eur Respir Rev doi: 10.1183/09059180.00003214 – volume: 14 start-page: 575 issue: 7 year: 2015 ident: ref13 article-title: Where are we going in the management of interstitial lung disease in patients with systemic sclerosis? publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2015.02.002 – volume: 40 start-page: 1700 issue: 5 year: 2008 ident: ref50 article-title: Therapeutic effects of bone marrow-derived mesenchymal stem cells engraftment on bleomycin-induced lung injury in rats publication-title: Transplant Proc doi: 10.1016/j.transproceed.2008.01.080 – volume: 13 start-page: 1922 issue: 5 year: 2017 ident: ref51 article-title: Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report publication-title: Exp Ther Med doi: 10.3892/etm.2017.4222 – volume: 17 start-page: S3 issue: Suppl 1 year: 2011 ident: ref54 article-title: Inflammation, chronic obstructive pulmonary disease and aging publication-title: Curr Opin Pulm Med doi: 10.1097/01.mcp.0000410742.90463.1f – volume: 2015 start-page: 816460 year: 2015 ident: ref31 article-title: Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms publication-title: Mediators Inflamm doi: 10.1155/2015/816460 – volume: 41 start-page: 467 issue: 4 year: 1988 ident: ref24 article-title: Simple method of estimating severity of pulmonary fibrosis on a numerical scale publication-title: J Clin Pathol doi: 10.1136/jcp.41.4.467 – volume: 126 start-page: 220 issue: 2 year: 2009 ident: ref17 article-title: The immunomodulatory activity of human umbilical cord blood-derived mesenchymal stem cells in vitro publication-title: Immunology doi: 10.1111/j.1365-2567.2008.02891.x – volume: 30 start-page: 473 issue: 6 year: 2008 ident: ref22 article-title: Immunohistochemical detection and localization of somatostatin receptor subtypes in prostate tissue from patients with bladder outlet obstruction publication-title: Cell Oncol – volume: 6 start-page: 602 year: 2015 ident: ref41 article-title: Macrophages During the Fibrotic Process: M2 as Friend and Foe publication-title: Front Immunol doi: 10.3389/fimmu.2015.00602 – volume: 354 start-page: 2655 issue: 25 year: 2006 ident: ref8 article-title: Cyclophosphamide versus placebo in scleroderma lung disease publication-title: N Engl J Med doi: 10.1056/NEJMoa055120 – volume: 118 start-page: 330 issue: 2 year: 2011 ident: ref46 article-title: Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages publication-title: Blood doi: 10.1182/blood-2010-12-327353 – reference: 25709096 - Autoimmun Rev. 2015 Jul;14(7):575-8 – reference: 22378047 - J Clin Invest. 2012 Mar;122(3):787-95 – reference: 17570349 - Brain Res. 2007 Jul 16;1158:71-80 – reference: 29204746 - Cell Tissue Res. 2018 Apr;372(1):51-65 – reference: 27460855 - Stem Cells Transl Med. 2016 Dec;5(12 ):1668-1675 – reference: 21577320 - Int J Clin Exp Pathol. 2011 Apr;4(4):349-55 – reference: 28694385 - J Exp Med. 2017 Aug 7;214(8):2387-2404 – reference: 26857227 - Cytotherapy. 2016 Mar;18(3):320-35 – reference: 17717203 - Am J Respir Crit Care Med. 2007 Nov 15;176(10):1026-34 – reference: 26044082 - Cell Transplant. 2016;25(2):217-28 – reference: 26635814 - Front Immunol. 2015 Nov 25;6:602 – reference: 24798808 - Cytotechnology. 2015 Oct;67(5):793-807 – reference: 26089604 - Mediators Inflamm. 2015;2015:816460 – reference: 17133610 - Arthritis Rheum. 2006 Dec;54(12):3962-70 – reference: 18936524 - Cell Oncol. 2008;30(6):473-82 – reference: 25808833 - Arthritis Rheumatol. 2015 Jul;67(7):1891-903 – reference: 27871152 - Int J Stem Cells. 2016 Nov 30;9(2):192-206 – reference: 23056000 - Front Immunol. 2012 Sep 26;3:297 – reference: 26779185 - Front Immunol. 2016 Jan 06;6:648 – reference: 28565787 - Exp Ther Med. 2017 May;13(5):1922-1926 – reference: 19497992 - Am J Pathol. 2009 Jul;175(1):303-13 – reference: 21417678 - Cytotherapy. 2011 Aug;13(7):786-801 – reference: 16790698 - N Engl J Med. 2006 Jun 22;354(25):2655-66 – reference: 24297321 - Int J Mol Med. 2014 Feb;33(2):263-70 – reference: 18589176 - Transplant Proc. 2008 Jun;40(5):1700-5 – reference: 25035950 - Immunity. 2014 Jul 17;41(1):14-20 – reference: 27941129 - Ann Rheum Dis. 2017 Aug;76(8):1327-1339 – reference: 25058083 - JAMA. 2014 Jun 25;311(24):2490-8 – reference: 23734780 - Stem Cell Res Ther. 2013 Jun 04;4(3):65 – reference: 25957945 - Stem Cell Res. 2015 Jul;15(1):1-13 – reference: 17257581 - Biochem Biophys Res Commun. 2007 Mar 16;354(3):700-6 – reference: 24217581 - Nat Rev Rheumatol. 2014 Feb;10 (2):117-24 – reference: 29038604 - Sci Rep. 2017 Oct 16;7(1):13281 – reference: 18624725 - Immunology. 2009 Feb;126(2):220-32 – reference: 26474311 - Arthritis Rheumatol. 2016 Apr;68(4):1013-25 – reference: 26525582 - Arthritis Res Ther. 2015 Nov 03;17:301 – reference: 12815096 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8407-11 – reference: 23505314 - J Leukoc Biol. 2013 Jun;93(6):875-81 – reference: 22095546 - Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46 – reference: 25726561 - Eur Respir Rev. 2015 Mar;24(135):102-14 – reference: 24596659 - Adv Biosci Biotechnol. 2014 Jan;5(1):19-30 – reference: 1513263 - Microbiol Immunol. 1992;36(5):465-78 – reference: 19487223 - Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii40-4 – reference: 26807758 - Matrix Biol. 2016 Apr;51:7-13 – reference: 22209928 - Curr Opin Pulm Med. 2011 Dec;17 Suppl 1:S3-10 – reference: 21551236 - Blood. 2011 Jul 14;118(2):330-8 – reference: 25385603 - Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16766-71 – reference: 3366935 - J Clin Pathol. 1988 Apr;41(4):467-70 – reference: 27789101 - Trends Endocrinol Metab. 2017 Mar;28(3):199-212 – reference: 26142543 - Immunol Lett. 2015 Dec;168(2):201-7 – reference: 25007944 - Arthritis Res Ther. 2014 Jul 08;16(4):R144 – reference: 23132820 - Stem Cells. 2013 Feb;31(2):317-26 – reference: 18250477 - J Immunol. 2008 Feb 15;180(4):2650-8 – reference: 26804815 - Ocul Surf. 2016 Apr;14 (2):121-34
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Snippet	Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those...
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SubjectTerms	Aging Biology and Life Sciences Bleomycin Bone marrow Cesarean section Clinical trials Collagen Connective tissue diseases Connective tissues Etiology Fibrosis Health aspects Immunocompetence In vivo methods and tests Inflammation Injury prevention Interleukin 1 Interleukin 10 Interleukin 6 Lung diseases Lungs Macrophages Medical research Medicine and Health Sciences Mesenchymal stem cells Mesenchyme Mice Prevention Pulmonary fibrosis Rats Research and Analysis Methods Stem cells Stromal cells Therapy Transplants & implants Umbilical cord
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Title	Mesenchymal stromal cells from human umbilical cord prevent the development of lung fibrosis in immunocompetent mice
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