Regulation of sialidase production in Clostridium perfringens by the orphan sensor histidine kinase ReeS

• Published in: PloS one Vol. 8; no. 9; p. e73525
• Main Authors: Hiscox, Thomas J, Harrison, Paul F, Chakravorty, Anjana, Choo, Jocelyn M, Ohtani, Kaori, Shimizu, Tohru, Cheung, Jackie K, Rood, Julian I
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.09.2013; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Bioinformatics; Cellular signal transduction; Clostridium perfringens; Clostridium perfringens - cytology; Clostridium perfringens - enzymology; Clostridium perfringens - genetics; Clostridium perfringens - metabolism; Clostripain; Collagen; Complementation; Consortia; Cysteine; Cysteine proteinase; Deoxyribonucleic acid; Disease; DNA; DNA microarrays; E coli; Enzymes; Ethics; Etiology; Experiments; Extracellular enzymes; Extracellular Space - metabolism; Female; Gangrene; Gas gangrene; Gastrointestinal tract; Gene expression; Gene Expression Regulation, Bacterial; Genes; Gram-positive bacteria; Health aspects; Histidine; Histidine Kinase; Kinases; Medical research; Mice; Mice, Inbred BALB C; Mutation; Myonecrosis; Neuraminidase - biosynthesis; Neuraminidase - genetics; Pathogenesis; Plasmids; Protein Kinases - genetics; Protein Kinases - metabolism; Reverse transcription; Sensors; Signal transduction; Streptococcus infections; Toxins; Transduction; Virulence; Virulence (Microbiology); α-Toxin; Australia; Victoria Australia

Clostridium perfringens is ubiquitous in nature and is often found as a commensal of the human and animal gastrointestinal tract. It is the primary etiological agent of clostridial myonecrosis, or gas gangrene, a serious infection that results in extensive tissue necrosis due to the action of one or...