Englerin A Selectively Induces Necrosis in Human Renal Cancer Cells

• Published in: PloS one Vol. 7; no. 10; p. e48032
• Main Authors: Sulzmaier, Florian J., Li, Zhenwu, Nakashige, Mika L., Fash, David M., Chain, William J., Ramos, Joe W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.10.2012; Public Library of Science (PLoS)
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Bioengineering; Biological effects; Biology; Calcium; Calcium - metabolism; Calcium influx; Cancer; Cancer cells; Cancer therapies; Cell death; Cell growth; Cell Line, Tumor; Cell Survival - drug effects; Chloroquine - pharmacology; Cytokines; Cytoplasm; Cytoplasm - drug effects; Cytoplasm - metabolism; Cytotoxicity; Diagnosis; Dose-Response Relationship, Drug; Gene expression; Health aspects; HEK293 Cells; Humans; Kidney cancer; Kidney Neoplasms - drug therapy; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Kidneys; Kinases; Medicine; Mode of action; Molecular Structure; Mutation; Natural products; Necrosis; Oxygen; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Renal cell carcinoma; Rodents; Sesquiterpenes, Guaiane - chemistry; Sesquiterpenes, Guaiane - pharmacology; Signaling; Staurosporine - pharmacology; Target recognition; Toxicity; Tumor cells; Hawaii; United States > US

The number of renal cancers has increased over the last ten years and patient survival in advanced stages remains very poor. Therefore, new therapeutic approaches for renal cancer are essential. Englerin A is a natural product with a very potent and selective cytotoxicity against renal cancer cells....