Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study

• Published in: PloS one Vol. 13; no. 9; p. e0204413
• Main Authors: Lee, Joonki, Jung, Sun Jae, Choi, Jae-won, Shin, Aesun, Lee, Yu Jin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.09.2018; Public Library of Science (PLoS)
• Subjects: Alzheimer's disease; Anesthesia; Antidepressants; Antipsychotics; Benzodiazepines; Care and treatment; Cognitive ability; Cohort analysis; Dementia; Dementia disorders; Dosage and administration; Drug dosages; Epidemiology; Exposure; Half-life; Health care; Health risk assessment; Hypnotics; Hypnotics and sedatives; Insomnia; Medical diagnosis; Medicine and Health Sciences; Population; Prescription drugs; Preventive medicine; Psychotropic drugs; Public health; Regression analysis; Regression models; Risk factors; Sensitivity analysis; Sleep disorders; Studies; Systematic review; Time dependence; Zolpidem; South Korea

There has been a growing interest in the relationship between sedative-hypnotics use and the risk of Alzheimer's dementia (AD) risk. This study aimed to evaluate the risk of AD associated with the use of sedative-hypnotics. A retrospective cohort study was conducted with randomly selected 5% sa...