IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells

• Published in: PloS one Vol. 10; no. 8; p. e0132743
• Main Authors: Qi, Yiming, Li, Ying, Zhang, Yingke, Zhang, Lin, Wang, Zilian, Zhang, Xuzhi, Gui, Lian, Huang, Junqi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.08.2015; Public Library of Science (PLoS)
• Subjects: Apoptosis; Apoptosis - genetics; BAX protein; Bcl-2 protein; bcl-2-Associated X Protein - genetics; bcl-2-Associated X Protein - metabolism; Biological response modifiers; Biotechnology; Care and treatment; Caspase; Caspase-3; Caspase-9; Cell Line; Cell lines; Dengue - virology; Dengue fever; Dengue hemorrhagic fever; Dengue Virus; Depolarization; Diagnosis; DNA microarrays; Down-Regulation; Endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - virology; Endothelium; Endothelium, Vascular - metabolism; Endothelium, Vascular - virology; Fever; Fluorescence; Genomics; Health aspects; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Human Umbilical Vein Endothelial Cells - virology; Humans; Incubation; Infections; Infectious diseases; Interferon; Kinases; Medical treatment; Membrane potential; Mitochondria; Mitochondria - genetics; Mitochondria - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Protein X; Proteins; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Risk factors; Signal Transduction - genetics; Tropical diseases; Up-Regulation; Vector-borne diseases; Viral diseases; Viruses; X-Linked Inhibitor of Apoptosis Protein - genetics; X-Linked Inhibitor of Apoptosis Protein - metabolism; XIAP protein; α-Interferon; China

Dengue hemorrhagic fever (DHF)/Dengue shock syndrome (DSS) is a fatal infectious disease that demands an effective treatment. Interferon (IFN)-stimulated genes (ISGs) induced by dengue virus (DENV) exert antiviral effects. Among ISGs, IFN-α inducible gene 6 (IFI6) was increased in DENV infected huma...