CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

• Published in: PloS one Vol. 10; no. 5; p. e0127507
• Main Authors: Hua, Wei, Huang, Hui-zhe, Tan, Lan-ting, Wan, Jiang-min, Gui, Hai-bo, Zhao, Liang, Ruan, Xiong-zhong, Chen, Xue-mei, Du, Xiao-gang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.05.2015; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Antigens; Antioxidants; Apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Arteriosclerosis; Atherosclerosis; Binding sites; CD36 antigen; CD36 Antigens - genetics; CD36 Antigens - metabolism; Complications and side effects; Cyclic N-Oxides - pharmacology; Cytometry; Cytoplasm; Diabetes; Diabetes mellitus; Diabetic nephropathy; Epithelial cells; Fatty acids; Fibrosis; Flow cytometry; Fluorescence; Genetic aspects; Hepatocytes; Hospitals; Humans; Hyperlipidemia; Immunofluorescence; Immunohistochemistry; Kidney - drug effects; Kidney - metabolism; Kidney diseases; Kidneys; Laboratories; Lipids; Liver; Low density lipoprotein; Macrophages; Mice; Nephrology; Nephropathy; Oleic Acids - pharmacology; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Palmitic acid; Palmitic Acid - pharmacology; Patients; Physiological aspects; Podocytes - drug effects; Podocytes - metabolism; Reactive oxygen species; Reactive Oxygen Species - metabolism; Rodents; Spin Labels; Staining; Statistical analysis; Statistical methods; Statistics; Studies; Succinimides - pharmacology; Translocation; China

Hyperlipidemia-induced apoptosis mediated by fatty acid translocase CD36 is associated with increased uptake of ox-LDL or fatty acid in macrophages, hepatocytes and proximal tubular epithelial cells, leading to atherosclerosis, liver damage and fibrosis in obese patients, and diabetic nephropathy (D...