Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis

• Published in: PloS one Vol. 12; no. 11; p. e0188631
• Main Authors: Doan, Tan N., Eisen, Damon P., Rose, Morgan T., Slack, Andrew, Stearnes, Grace, McBryde, Emma S.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.11.2017; Public Library of Science (PLoS)
• Subjects: Accuracy; Adults; Agreements; Antigens; Bacillus Calmette-Guerin vaccine; Bayesian analysis; BCG; Biology and Life Sciences; Children; Development and progression; Diagnosis; Diagnostic systems; Diagnostic tests; Disease; Genetic aspects; Health services; Hospitals; Infections; Interferon; Interferon gamma; Latent class analysis; Lupus; Mathematical models; Medical diagnosis; Medicine; Medicine and Health Sciences; Modelling; Patients; Physiological aspects; Population; Populations; Rheumatoid arthritis; Screening; Sensitivity; Sensitivity analysis; Skin tests; Studies; Systematic review; Tuberculin; Tuberculosis; Tumor necrosis factor-TNF; Vaccination; Australia; Queensland Australia; Victoria Australia

Accurate diagnosis and subsequent treatment of latent tuberculosis infection (LTBI) is essential for TB elimination. However, the absence of a gold standard test for diagnosing LTBI makes assessment of the true prevalence of LTBI and the accuracy of diagnostic tests challenging. Bayesian latent clas...