Comparison of Bone Mineral Density in Lumbar Spine and Fracture Rate among Eight Drugs in Treatments of Osteoporosis in Men: A Network Meta-Analysis

• Published in: PloS one Vol. 10; no. 5; p. e0128032
• Main Authors: Chen, Ling-Xiao, Zhou, Zhi-Rui, Li, Yu-Lin, Ning, Guang-Zhi, Zhang, Tian-Song, Zhang, Di, Feng, Shi-Qing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.05.2015; Public Library of Science (PLoS)
• Subjects: Alendronate - administration & dosage; Alendronate - adverse effects; Alendronic acid; Bias; Biocompatibility; Bisphosphonates; Bone density; Bone Density - drug effects; Bone Density Conservation Agents - administration & dosage; Bone Density Conservation Agents - adverse effects; Bone disorder agents; Bone mineral density; Clinical trials; Comparative analysis; Cooperation; Diphosphonates - administration & dosage; Diphosphonates - adverse effects; Drug therapy; Drugs; Endocrinology; Fractures; Fractures, Bone - chemically induced; Fractures, Bone - epidemiology; Gynecology; Health aspects; Hierarchies; Hospitals; Humans; Hydroxycholecalciferols - administration & dosage; Hydroxycholecalciferols - adverse effects; Ibandronic Acid; Imidazoles - administration & dosage; Imidazoles - adverse effects; Internal medicine; Lumbar Vertebrae - drug effects; Lumbar Vertebrae - injuries; Men; Meta-analysis; Nursing; Osteoporosis; Osteoporosis - complications; Osteoporosis - drug therapy; Parathyroid; Parathyroid hormone; Parathyroid Hormone - administration & dosage; Parathyroid Hormone - adverse effects; Physiological aspects; Risedronic acid; Risedronic Acid - administration & dosage; Risedronic Acid - adverse effects; Scientific papers; Spine; Spine (lumbar); Strontium; Studies; Systematic review; Technical information; Teriparatide - administration & dosage; Teriparatide - adverse effects; Therapy; Thiophenes - administration & dosage; Thiophenes - adverse effects; Vitamin D; Zoledronic Acid; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0128032

The preferred treatment for osteoporosis in men is debated, and pairwise meta-analysis cannot obtain hierarchies of these treatments. The objective of this study was to integrate the evidence and provide hierarchies of eight drugs based on their effect on the bone mineral density in the lumbar spine...