Clade II Candida auris possess genomic structural variations related to an ancestral strain

• Published in: PloS one Vol. 14; no. 10; p. e0223433
• Main Authors: Sekizuka, Tsuyoshi, Iguchi, Shigekazu, Umeyama, Takashi, Inamine, Yuba, Makimura, Koichi, Kuroda, Makoto, Miyazaki, Yoshitsugu, Kikuchi, Ken
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.10.2019; Public Library of Science (PLoS)
• Subjects: Acids; Antifungal agents; Bioinformatics; Biology and life sciences; Biosynthesis; Candida - classification; Candida - genetics; Candida - metabolism; Candida auris; Candidiasis; Cell walls; Chemotherapy; Computer and Information Sciences; Conserved Sequence; Copy number; DNA sequencing; Drug resistance; Drug therapy; Ear diseases; Epidemics; Epidemiology; Ergosterol; Evolution, Molecular; Fluconazole; Fungal infections; Fungicides; Gene duplication; Gene mutations; Gene sequencing; Genes; Genetic aspects; Genome, Fungal; Genomes; Genomics; Infections; Infectious diseases; Medicine and Health Sciences; Mitochondrial DNA; Multidrug resistance; Mutation; Nucleotide sequencing; Nucleotides; Otitis media; Patients; People and Places; Phylogenetics; Phylogeny; Polymorphism, Genetic; Research and analysis methods; Risk factors; Stress, Physiological - genetics; Variation; Whole genome sequencing; Yeast; Yeasts; Venezuela; South Korea; Pakistan; United States > US; Japan; South Africa; India

Candida auris is an invasive and multidrug-resistant ascomycetous yeast that is under global surveillance. All clinical cases of C. auris infection diagnosed from 1997 to 2019 in Japan were non-invasive and sporadic otitis media cases. In the present study, we performed whole-genome sequencing of se...