MiR-196a Promotes Pancreatic Cancer Progression by Targeting Nuclear Factor Kappa-B-Inhibitor Alpha

• Published in: PloS one Vol. 9; no. 2; p. e87897
• Main Authors: Huang, Fengting, Tang, Jian, Zhuang, Xiaohong, Zhuang, Yanyan, Cheng, Wenjie, Chen, Wenbo, Yao, Herui, Zhang, Shineng
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04.02.2014; Public Library of Science (PLoS)
• Subjects: 3' Untranslated Regions; Aberration; Apoptosis; Apoptosis - genetics; Base Sequence; Biology; Biotechnology; Cancer; Cancer metastasis; Cell Cycle - genetics; Cell growth; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation; Cluster Analysis; Colorectal cancer; Comparative analysis; Cyclin D1; Cyclin-dependent kinase 4; Disease Progression; DNA microarrays; E-cadherin; Epithelial cells; Gastroenterology; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Growth factors; Humans; I-kappa B Proteins - chemistry; I-kappa B Proteins - genetics; Inhibitors; Luciferase; Lymphoma; Medical prognosis; Medicine; Melanoma; Metastases; Metastasis; MicroRNA; MicroRNAs; MicroRNAs - chemistry; MicroRNAs - genetics; miRNA; N-Cadherin; NF-KappaB Inhibitor alpha; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Penicillin; RNA Interference; Skin cancer; Target recognition; Tumor cell lines; Vimentin

Aberrant expression of miR-196a has been frequently reported in different cancers including pancreatic cancer. However, its function in pancreatic cancer has not been fully elucidated. Here, we investigated the expression pattern and the biological role of miR-196a in pancreatic cancer cell lines, a...