Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells

• Published in: PloS one Vol. 12; no. 3; p. e0174935
• Main Authors: Seo, Yohan, Ryu, Kunhi, Park, Jinhong, Jeon, Dong-kyu, Jo, Sungwoo, Lee, Ho K., Namkung, Wan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.03.2017; Public Library of Science (PLoS)
• Subjects: Analysis; Aniline Compounds - pharmacology; Animals; Anoctamin-1; Anticancer properties; Biocompatibility; Biology and Life Sciences; Calcium; Calcium (intracellular); Calcium - metabolism; Calcium chloride; Calcium signalling; Cancer screening; Cell cycle; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cells, Cultured; Channel gating; Chloride channels (calcium-gated); Chloride Channels - antagonists & inhibitors; Chloride Channels - metabolism; Chloride ions; Cytotoxicity; Gene expression; Growth factors; Health aspects; Humans; Immunoblotting; Intracellular signalling; Ion channels; Kaempferols - pharmacology; Kinases; Luteolin - pharmacology; Male; Medicine and Health Sciences; Molecular biology; Natural products; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - metabolism; Patch-Clamp Techniques; Penicillin; Pharmaceutical sciences; Pharmacology; Pharmacy; Physical Sciences; Prostate cancer; Prostatic Neoplasms - metabolism; Rats; Real-Time Polymerase Chain Reaction; Rodents; Signal transduction; Studies; Toxicity; Wound Healing - drug effects; Xanthenes - pharmacology

Anoctamin 1 (ANO1), a calcium-activated chloride channel, is highly amplified in prostate cancer, the most common form of cancer and leading causes of cancer death in men, and downregulation of ANO1 expression or its functional activity is known to inhibit cell proliferation, migration and invasion...