Tanzawaic Acids, a Chemically Novel Set of Bacterial Conjugation Inhibitors

• Published in: PloS one Vol. 11; no. 1; p. e0148098
• Main Authors: Getino, María, Fernández-López, Raúl, Palencia-Gándara, Carolina, Campos-Gómez, Javier, Sánchez-López, Jose M, Martínez, Marta, Fernández, Antonio, de la Cruz, Fernando
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.01.2016; Public Library of Science (PLoS)
• Subjects: Acids; Antibacterial agents; Antibiotic resistance; Antibiotics; Antifungal agents; Antimicrobial agents; Aspergillus nidulans - drug effects; Aspergillus nidulans - genetics; Bacteria; Biological Products - chemical synthesis; Biological Products - chemistry; Biological Products - pharmacology; Biology and life sciences; Candida albicans - drug effects; Candida albicans - genetics; Care and treatment; Cell Line; Cell Survival - drug effects; Coins; Conjugation; Conjugation, Genetic - drug effects; E coli; Escherichia coli; Fatty acids; Fatty Acids, Unsaturated - chemical synthesis; Fatty Acids, Unsaturated - chemistry; Fatty Acids, Unsaturated - pharmacology; Fractionation; Genetic aspects; HCT116 Cells; Humans; Immunology; Incompatibility; Incp plasmids; Inhibitors; Medicine and Health Sciences; Microbial drug resistance; Microbial Sensitivity Tests; Microorganisms; Molecular biology; Mycobacterium smegmatis - drug effects; Mycobacterium smegmatis - genetics; Naphthalenes - chemical synthesis; Naphthalenes - chemistry; Naphthalenes - pharmacology; NMR; Nuclear magnetic resonance; Physical Sciences; Plasmids; Plasmids - genetics; Plasmids - metabolism; RNA polymerase; Stem cells; Toxicity; United States; Spain; United States > US

Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance in human pathogens. This dissemination could be controlled by molecules that interfere with the conjugation process. A search for conjugation inhibitors among a collection of 1,632 natural compounds,...