CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver

• Published in: PloS one Vol. 8; no. 6; p. e65070
• Main Authors: Yang, Chih-Ya, Chen, Jiun-Bo, Tsai, Ting-Fen, Tsai, Yi-Chen, Tsai, Ching-Yen, Liang, Pi-Hui, Hsu, Tsui-Ling, Wu, Chung-Yi, Netea, Mihai G., Wong, Chi-Huey, Hsieh, Shie-Liang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.06.2013; Public Library of Science (PLoS)
• Subjects: Abscesses; Acetylgalactosamine - chemistry; Acetylgalactosamine - immunology; Animal tissues; Animals; Antigens; Antigens, Differentiation - genetics; Antigens, Differentiation - immunology; Binding; Binding Sites; Biology; Calcium; Carbohydrate Sequence; Cell migration; Embryo, Mammalian; Embryos; Fetuses; Fucose; Galactose; Galactose - chemistry; Galactose - immunology; Galactosylceramide; Galactosylceramides - chemistry; Galactosylceramides - immunology; Gene Expression Regulation, Developmental; Genomics; Glycan; Glycolipids; Glycosylation; Hepatocytes; Immunology; Infections; Kupffer cells; Kupffer Cells - immunology; Kupffer Cells - metabolism; Kupffer Cells - microbiology; Laboratory animals; Lectins; Lectins, C-Type - chemistry; Lectins, C-Type - genetics; Lectins, C-Type - immunology; Leukocytes (mononuclear); Listeria; Listeria monocytogenes; Listeria monocytogenes - immunology; Listeriosis - genetics; Listeriosis - immunology; Listeriosis - metabolism; Listeriosis - microbiology; Liver; Liver - immunology; Liver - metabolism; Liver - microbiology; Liver diseases; Medicine; Membrane lipids; Membrane proteins; Mice; Mice, Knockout; Molecular Sequence Data; Monocytes; Monocytes - immunology; Monocytes - metabolism; Monocytes - microbiology; N-Acetylgalactosamine; Natural killer cells; Natural Killer T-Cells - immunology; Natural Killer T-Cells - metabolism; Natural Killer T-Cells - microbiology; Plant lipids; Polysaccharides; Protein Binding; Rodents; Studies; T cell receptors; Yolk; Yolk sac; Taiwan

CLEC4F, a member of C-type lectin, was first purified from rat liver extract with high binding affinity to fucose, galactose (Gal), N-acetylgalactosamine (GalNAc), and un-sialylated glucosphingolipids with GalNAc or Gal terminus. However, the biological functions of CLEC4F have not been elucidated....