Adaptation of enterovirus 71 to adult interferon deficient mice

• Published in: PloS one Vol. 8; no. 3; p. e59501
• Main Authors: Caine, Elizabeth A, Partidos, Charalambos D, Santangelo, Joseph D, Osorio, Jorge E
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.03.2013; Public Library of Science (PLoS)
• Subjects: Adaptation; Alum; Aluminum sulfate; Analysis; Animals; Antisera; Biological response modifiers; Biology; Brain; Cell culture; Correlation analysis; Coxsackievirus infections; Disease; Disease Models, Animal; Disease susceptibility; Encephalitis; Enterovirus; Enterovirus A, Human - genetics; Enterovirus A, Human - physiology; Epidemics; Foot and mouth disease; Genotypes; Hand, Foot and Mouth Disease - immunology; Hand, Foot and Mouth Disease - virology; Hand-foot-and-mouth disease; Homology; Humoral immunity; Immune Sera - administration & dosage; Immune Sera - immunology; Immune Sera - pharmacology; Immune serum; Immunity; Immunogenicity; Infections; Interferon; Irritation; Laboratory animals; Lethality; Medicine; Mice; Mice, Knockout; Mortality; Neonates; Nervous system; Neutralization Tests; Paralysis; Pathogenesis; Poliomyelitis; Rabbits; Real-Time Polymerase Chain Reaction; Receptor, Interferon alpha-beta - deficiency; Receptor, Interferon alpha-beta - genetics; Reverse Transcriptase Polymerase Chain Reaction; Serial Passage - methods; Vaccination; Vaccines; Veterinary colleges; Veterinary medicine; Viral infections; Viral Vaccines - immunology; Viruses; Vietnam; Singapore; United States > US; China; Japan; Wisconsin

Non-polio enteroviruses, including enterovirus 71 (EV71), have caused severe and fatal cases of hand, foot and mouth disease (HFMD) in the Asia-Pacific region. The development of a vaccine or antiviral against these pathogens has been hampered by the lack of a reliable small animal model. In this st...