Blood-based protein biomarker panel for the detection of colorectal cancer

• Published in: PloS one Vol. 10; no. 3; p. e0120425
• Main Authors: Fung, Kim Y C, Tabor, Bruce, Buckley, Michael J, Priebe, Ilka K, Purins, Leanne, Pompeia, Celine, Brierley, Gemma V, Lockett, Trevor, Gibbs, Peter, Tie, Jeanne, McMurrick, Paul, Moore, James, Ruszkiewicz, Andrew, Nice, Edouard, Adams, Timothy E, Burgess, Antony, Cosgrove, Leah J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.03.2015; Public Library of Science (PLoS)
• Subjects: Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Biomarkers; Biomarkers, Tumor - blood; Blood; Blood tests; Cancer; Cancer diagnosis; Carrier Proteins - blood; Case-Control Studies; Chemokines; Clinical trials; Colonoscopy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - blood; Colorectal Neoplasms - pathology; Deoxyribonucleic acid; Diagnostic software; Diagnostic systems; DNA; DNA methylation; Feces; Female; Gastroenterology; Gene expression; Genetic testing; Hospitals; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 2 - blood; Insulin-like growth factor-binding protein 2; Intercellular Signaling Peptides and Proteins - blood; Kinases; Male; Medical diagnosis; Medical screening; Membrane Proteins - blood; Middle Aged; Mortality; Patients; Polyps; Population; Protein binding; Proteins; Pyruvate kinase; Pyruvic acid; Risk analysis; Risk factors; Sensitivity; Studies; Systematic review; Thyroid Hormone-Binding Proteins; Thyroid Hormones - blood; Tumors; United Kingdom > UK; United States > US; Europe; Japan; Victoria Australia; Australia; South Australia Australia

The majority of colorectal cancer (CRC) cases are preventable by early detection and removal of precancerous polyps. Even though CRC is the second most common internal cancer in Australia, only 30 per cent of the population considered to have risk factors participate in stool-based test screening pr...