Study of the Cardiotoxicity of Venenum Bufonis in Rats using an 1H NMR-Based Metabolomics Approach

• Published in: PloS one Vol. 10; no. 3; p. e0119515
• Main Authors: Dong, Ge, Wei, Dandan, Wang, Junsong, Guo, Pingping, Li, Minghui, Yang, Minghua, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.03.2015; Public Library of Science (PLoS)
• Subjects: Amino acids; Animals; Bioengineering; Biomarkers; Bufanolides - toxicity; Cardiotoxicity; Cardiotoxins - toxicity; Chemistry; Chinese medicine; Damage assessment; Dose-Response Relationship, Drug; Energy metabolism; Experiments; Heart; Heart diseases; Herbal medicine; Laboratory animals; Liver; Magnetic Resonance Spectroscopy; Male; Metabolism; Metabolites; Metabolome - drug effects; Metabolomics; Mitochondria; Myocardium - metabolism; Myocardium - pathology; NMR; Nuclear magnetic resonance; Oxidative stress; Pharmaceutical sciences; Rats; Rodents; Side effects; Toxicity; Traditional Chinese medicine; Urine; United States > US; China

Venenum Bufonis, a well-known traditional Chinese medicine, has been widely used in Asia and has gained popularity in Western countries over the last decade. Venenum Bufonis has obvious side effects that have been observed in clinical settings, but few studies have reported on its cardiotoxicity. In...