Study of the Cardiotoxicity of Venenum Bufonis in Rats using an 1H NMR-Based Metabolomics Approach - Dong, Ge; Wei, Dandan; Wang, Junsong; Guo, Pingping; Li, Minghui; Yang, Minghua; Kong, Lingyi (PloS one, 2015)
Keywords: Amino acids; Animals; Bioengineering; Biomarkers; Bufanolides - toxicity; Cardiotoxicity; Cardiotoxins - toxicity; Chemistry; Chinese medicine; Damage assessment; Dose-Response Relationship, Drug; Energy metabolism; Experiments; Heart; Heart diseases; Herbal medicine; Laboratory animals; Liver; Magnetic Resonance Spectroscopy; Male; Metabolism; Metabolites; Metabolome - drug effects; Metabolomics; Mitochondria; Myocardium - metabolism; Myocardium - pathology; NMR; Nuclear magnetic resonance; Oxidative stress; Pharmaceutical sciences; Rats; Rodents; Side effects; Toxicity; Traditional Chinese medicine; Urine; United States--US; China